PMID- 30711534
OWN - NLM
STAT- MEDLINE
DCOM- 20191219
LR  - 20200315
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Print)
IS  - 0041-008X (Linking)
VI  - 367
DP  - 2019 Mar 15
TI  - Maternal titanium dioxide nanomaterial inhalation exposure compromises placental 
      hemodynamics.
PG  - 51-61
LID - S0041-008X(19)30040-7 [pii]
LID - 10.1016/j.taap.2019.01.024 [doi]
AB  - The fetal consequences of gestational engineered nanomaterial (ENM) exposure are 
      unclear. The placenta is a barrier protecting the fetus and allowing transfer of 
      substances from the maternal circulation. The purpose of this study was to 
      determine the effects of maternal pulmonary titanium dioxide nanoparticle 
      (nano-TiO(2)) exposure on the placenta and umbilical vascular reactivity. We 
      hypothesized that pulmonary nano-TiO(2) inhalation exposure increases placental 
      vascular resistance and impairs umbilical vascular responsiveness. Pregnant 
      Sprague-Dawley rats were exposed via whole-body inhalation to nano-TiO(2) with an 
      aerodynamic diameter of 188 +/- 0.36 nm. On gestational day (GD) 11, rats began 
      inhalation exposures (6 h/exposure). Daily lung deposition was 87.5 +/- 2.7 mug. 
      Animals were exposed for 6 days for a cumulative lung burden of 525 +/- 16 mug. On 
      GD 20, placentas, umbilical artery and vein were isolated, cannulated, and 
      treated with acetylcholine (ACh), angiotensin II (ANGII), 
      S-nitroso-N-acetyl-DL-penicillamine (SNAP), or calcium-free superfusate 
      (Ca(2+)-free). Mean outflow pressure was measured in placental units. ACh 
      increased outflow pressure to 53 +/- 5 mmHg in sham-controls but only to 
      35 +/- 4 mmHg in exposed subjects. ANGII decreased outflow pressure in placentas 
      from exposed animals (17 +/- 7 mmHg) compared to sham-controls (31 +/- 6 mmHg). 
      Ca(2+)-free superfusate yielded maximal outflow pressures in sham-control 
      (63 +/- 5 mmHg) and exposed (30 +/- 10 mmHg) rats. Umbilical artery 
      endothelium-dependent dilation was decreased in nano-TiO(2) exposed fetuses 
      (30 +/- 9%) compared to sham-controls (58 +/- 6%), but ANGII sensitivity was 
      increased (-79 +/- 20% vs -36 +/- 10%). These results indicate that maternal 
      gestational pulmonary nano-TiO(2) exposure increases placental vascular 
      resistance and impairs umbilical vascular reactivity.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Abukabda, Alaeddin B
AU  - Abukabda AB
AD  - Department of Physiology and Pharmacology, West Virginia University School of 
      Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University 
      School of Medicine, Morgantown, WV, USA.
FAU - Bowdridge, Elizabeth C
AU  - Bowdridge EC
AD  - Department of Physiology and Pharmacology, West Virginia University School of 
      Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University 
      School of Medicine, Morgantown, WV, USA.
FAU - McBride, Carroll R
AU  - McBride CR
AD  - Department of Physiology and Pharmacology, West Virginia University School of 
      Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University 
      School of Medicine, Morgantown, WV, USA.
FAU - Batchelor, Thomas P
AU  - Batchelor TP
AD  - Department of Physiology and Pharmacology, West Virginia University School of 
      Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University 
      School of Medicine, Morgantown, WV, USA.
FAU - Goldsmith, William T
AU  - Goldsmith WT
AD  - Department of Physiology and Pharmacology, West Virginia University School of 
      Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University 
      School of Medicine, Morgantown, WV, USA.
FAU - Garner, Krista L
AU  - Garner KL
AD  - Department of Physiology and Pharmacology, West Virginia University School of 
      Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University 
      School of Medicine, Morgantown, WV, USA.
FAU - Friend, Sherri
AU  - Friend S
AD  - National Institute for Occupational Safety and Health, Morgantown, WV, USA.
FAU - Nurkiewicz, Timothy R
AU  - Nurkiewicz TR
AD  - Department of Physiology and Pharmacology, West Virginia University School of 
      Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University 
      School of Medicine, Morgantown, WV, USA; National Institute for Occupational 
      Safety and Health, Morgantown, WV, USA. Electronic address: 
      tnurkiewicz@hsc.wvu.edu.
LA  - eng
GR  - R01 ES015022/ES/NIEHS NIH HHS/United States
GR  - U54 GM104942/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20190201
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 15FIX9V2JP (titanium dioxide)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Animals
MH  - Female
MH  - Hemodynamics/*drug effects
MH  - Inhalation Exposure
MH  - Maternal Exposure
MH  - Metal Nanoparticles/*toxicity
MH  - Placenta/*blood supply
MH  - Pregnancy
MH  - Rats, Sprague-Dawley
MH  - Titanium/*toxicity
PMC - PMC6422339
MID - NIHMS1521602
OTO - NOTNLM
OT  - Engineered nanomaterials
OT  - Microcirculation
OT  - Placenta
OT  - Titanium dioxide nanoparticles
EDAT- 2019/02/04 06:00
MHDA- 2019/12/20 06:00
PMCR- 2020/03/15
CRDT- 2019/02/04 06:00
PHST- 2018/12/03 00:00 [received]
PHST- 2019/01/28 00:00 [revised]
PHST- 2019/01/29 00:00 [accepted]
PHST- 2019/02/04 06:00 [pubmed]
PHST- 2019/12/20 06:00 [medline]
PHST- 2019/02/04 06:00 [entrez]
PHST- 2020/03/15 00:00 [pmc-release]
AID - S0041-008X(19)30040-7 [pii]
AID - 10.1016/j.taap.2019.01.024 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2019 Mar 15;367:51-61. doi: 10.1016/j.taap.2019.01.024. 
      Epub 2019 Feb 1.