PMID- 30711964
OWN - NLM
STAT- MEDLINE
DCOM- 20190220
LR  - 20190320
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 39
IP  - 2
DP  - 2019 Feb
TI  - Crypts With Corrupted Shapes in Non-polypoid Adenomas.
PG  - 833-838
LID - 10.21873/anticanres.13182 [doi]
AB  - BACKGROUND: Colonic crypts with normal epithelial lining exhibiting corrupted 
      shapes (NECS) have been previously found beneath the adenomatous tissue of 
      polypoid conventional adenomas, in both rats and humans. AIM: To assess the 
      frequency of NECS in non-polypoid colonic flat adenomas (FAs) and 
      lateral-spreading adenomas (LSAs). MATERIALS AND METHODS: Histological 
      hematoxylin and eosin-stained sections from 51 non-polypoid colonic adenomas were 
      scrutinized over a 10-mm field of vision (FOV). FAs were regarded lesions 
      encompassed within the FOV and LSAs as those surpassing that limit. The NECS/mm 
      ratio was calculated in individual lesions as the number of NECS beneath the 
      adenomatous tissue, divided by the length (mm) of the FA and LSA. RESULTS: Out of 
      the 51 non-polypoid adenomas, 27 were FAs and the remaining 24 LSAs. All 51 
      non-polypoid lesions were tubular adenomas. The mean number of NECS in FAs was 
      6.29 (range=2-10) and in LSAs was 15.29 (range=7-41) (p<0.05). On the other hand, 
      the mean NECS/mm ratio in FAs was 0.94 (range=0.50-2.00) and in LSAs was 0.92 
      (range=0.40-2.93). Thus, no essential differences in the number of NECS/mm was 
      found between FA and LSA. CONCLUSION: The accretion of NECS below the neoplastic 
      canopy of FA and LSA contrasts with the rare occurrence of NECS in normal colonic 
      mucosa. This finding emerges as a previously unaddressed major event, an event 
      that might play an important role in the histogenesis of non-polypoid adenomas of 
      the colon.
CI  - Copyright(c) 2019, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Rubio, Carlos A
AU  - Rubio CA
AD  - Gastrointestinal and Liver Research Laboratory, Department of Pathology, 
      Karolinska Institute and University Hospital, Stockholm, Sweden 
      Carlos.Rubio@ki.se.
FAU - Schmidt, Peter T
AU  - Schmidt PT
AD  - Department of Medicine Solna, Center for Digestive Diseases, Karolinska Institute 
      and University Hospital, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Adenoma/diagnosis/*pathology
MH  - Colon/*pathology
MH  - Colonic Neoplasms/diagnosis/*pathology
MH  - Humans
MH  - Intestinal Mucosa/*pathology
MH  - Phenotype
MH  - Polyploidy
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - Colon
OT  - crypts
OT  - distortions
OT  - flat adenomas
OT  - lateral-spreading adenomas
EDAT- 2019/02/04 06:00
MHDA- 2019/03/21 06:00
CRDT- 2019/02/04 06:00
PHST- 2018/12/08 00:00 [received]
PHST- 2018/12/14 00:00 [revised]
PHST- 2018/12/18 00:00 [accepted]
PHST- 2019/02/04 06:00 [entrez]
PHST- 2019/02/04 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
AID - 39/2/833 [pii]
AID - 10.21873/anticanres.13182 [doi]
PST - ppublish
SO  - Anticancer Res. 2019 Feb;39(2):833-838. doi: 10.21873/anticanres.13182.