PMID- 30712430
OWN - NLM
STAT- MEDLINE
DCOM- 20190624
LR  - 20190624
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 139
IP  - 1
DP  - 2019 Jan
TI  - Presentation of second primary cancers in young laryngeal carcinoma patients.
PG  - 85-89
LID - 10.1080/00016489.2018.1527037 [doi]
AB  - BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is rare in the young. 
      OBJECTIVES: We characterized the clinical behavior of LSCC and assessed the 
      presentation of second primary tumors (SPCs) in this patient population. 
      MATERIALS AND METHODS: Data from the Finnish Cancer Registry (FCR) were used to 
      identify an epidemiological series of LSCC patients diagnosed at the age of 40 
      years or under, during 1953-2012 in Finland. Data regarding primary treatment, 
      survival, and SPCs were available. To further characterize the comorbidity and 
      lifestyle factors of young patients with LSCC, institutional data were collected 
      of patients treated at the Helsinki University Hospital during 1967-2012. 
      RESULTS: We identified 151 patients, with a mean follow-up of 252 months. The 
      10-year overall survival (OS) was 75% and the disease-specific survival was 84%. 
      SPCs were diagnosed in 26% (n = 39), with a median delay of 28 years. Of the 35 
      patients in the institutional series from Helsinki, 22 (63%) were current or 
      former smokers. LSCC recurred in 28% of patients. CONCLUSIONS AND SIGNIFICANCE: 
      The delay to SPCs in young patients was significantly longer compared with the 
      general LSCC population. As factors underlying this phenomenon cannot be 
      identified by this retrospective study, further studies are warranted.
FAU - Silen, Suvi
AU  - Silen S
AUID- ORCID: 0000-0003-1240-0661
AD  - a Department of Otorhinolaryngology - Head and Neck Surgery , University of 
      Helsinki and Helsinki University Hospital , Helsinki , Finland.
AD  - b Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences , 
      Intervention and Technology, Karolinska Institutet, Karolinska University 
      Hospital , Stockholm , Sweden.
FAU - Haapaniemi, Aaro
AU  - Haapaniemi A
AUID- ORCID: 0000-0003-3097-1118
AD  - a Department of Otorhinolaryngology - Head and Neck Surgery , University of 
      Helsinki and Helsinki University Hospital , Helsinki , Finland.
FAU - Dickinson, Amy
AU  - Dickinson A
AD  - a Department of Otorhinolaryngology - Head and Neck Surgery , University of 
      Helsinki and Helsinki University Hospital , Helsinki , Finland.
FAU - Ronn, Karin
AU  - Ronn K
AD  - a Department of Otorhinolaryngology - Head and Neck Surgery , University of 
      Helsinki and Helsinki University Hospital , Helsinki , Finland.
FAU - Makitie, Antti
AU  - Makitie A
AUID- ORCID: 0000-0002-0451-2404
AD  - a Department of Otorhinolaryngology - Head and Neck Surgery , University of 
      Helsinki and Helsinki University Hospital , Helsinki , Finland.
AD  - b Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences , 
      Intervention and Technology, Karolinska Institutet, Karolinska University 
      Hospital , Stockholm , Sweden.
LA  - eng
PT  - Journal Article
DEP - 20190203
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Carcinoma, Squamous Cell/etiology/*mortality
MH  - Child
MH  - Female
MH  - Finland/epidemiology
MH  - Humans
MH  - Incidence
MH  - Laryngeal Neoplasms/etiology/*mortality
MH  - Male
MH  - Neoplasm Recurrence, Local/*epidemiology
MH  - Neoplasms, Second Primary/*epidemiology
MH  - *Registries
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Squamous cell carcinoma
OT  - laryngeal cancer
OT  - recurrence
OT  - risk factors
OT  - second primary cancer
OT  - survival
OT  - young patients
EDAT- 2019/02/05 06:00
MHDA- 2019/06/25 06:00
CRDT- 2019/02/05 06:00
PHST- 2019/02/05 06:00 [pubmed]
PHST- 2019/06/25 06:00 [medline]
PHST- 2019/02/05 06:00 [entrez]
AID - 10.1080/00016489.2018.1527037 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2019 Jan;139(1):85-89. doi: 10.1080/00016489.2018.1527037. Epub 
      2019 Feb 3.