PMID- 30713252
OWN - NLM
STAT- MEDLINE
DCOM- 20190708
LR  - 20231213
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 42
IP  - 2
DP  - 2019
TI  - Effect of Ocimum basilicum, Ocimum selloi, and Rosmarinic Acid on Cerebral 
      Vascular Damage in a Chronic Hypertension Model.
PG  - 201-211
LID - 10.1248/bpb.b18-00574 [doi]
AB  - The main objective of treatment against hypertension is not only to reduce blood 
      pressure levels, but also to reduce vascular risk in general. In the present 
      work, administering angiotensin II (AGII; 0.2 microg/kg intraperitoneally (i.p.) for 
      12 weeks) activates the hypothalamic-pituitary-adrenal (HPA) axis, which caused 
      an increase in corticosterone levels, as well as in proinflammatory cytokines 
      (interleukin 1beta (IL-1beta), interleukin 6 (IL-6), and tumor necrosis factor alpha 
      (TNF-alpha)) and macrophage chemotactic protein 1 (MCP-1), and decreased 
      anti-inflammatory cytokines (interleukin 10 (IL-10) and interleukin 4 (IL-4)). On 
      observing the behavior in the different models, an anxiogenic effect (elevated 
      plus maze (EPM)) and cognitive impairment (water Morris maze (WMM)) was observed 
      in animals with AGII. By administering organic extracts from Ocimum basilicum 
      (Oba-EtOAc) and Ocimum selloi (Ose-EtOAc), and some doses of rosmarinic acid (RA) 
      (6 weeks per os (p.o.)), the damage caused by AGII was stopped by re-establishing 
      corticosterone serum levels and by decreasing the proinflammatory cytokines and 
      MCP-1.
FAU - Alegria-Herrera, Elian
AU  - Alegria-Herrera E
AD  - Centro de Investigacion Biomedica del Sur, Instituto Mexicano del Seguro Social 
      (IMSS).
AD  - Doctorado en Ciencias Biologicas y de la Salud, Division de Ciencias Biologicas y 
      de la Salud, Universidad Autonoma Metropolitana-Iztapalapa.
AD  - Departamento Ciencias de la Salud, Division de Ciencias Biologicas y de la Salud, 
      Universidad Autonoma Metropolitana-Iztapalapa.
FAU - Herrera-Ruiz, Maribel
AU  - Herrera-Ruiz M
AD  - Centro de Investigacion Biomedica del Sur, Instituto Mexicano del Seguro Social 
      (IMSS).
FAU - Roman-Ramos, Ruben
AU  - Roman-Ramos R
AD  - Departamento Ciencias de la Salud, Division de Ciencias Biologicas y de la Salud, 
      Universidad Autonoma Metropolitana-Iztapalapa.
FAU - Zamilpa, Alejandro
AU  - Zamilpa A
AD  - Centro de Investigacion Biomedica del Sur, Instituto Mexicano del Seguro Social 
      (IMSS).
FAU - Santillan-Urquiza, Mayra Alejandra
AU  - Santillan-Urquiza MA
AD  - Centro de Investigacion Biomedica del Sur, Instituto Mexicano del Seguro Social 
      (IMSS).
FAU - Aguilar, Maria Isabel
AU  - Aguilar MI
AD  - Laboratorio 111, Departamento de Farmacia, Facultad de Quimica, Universidad 
      Nacional Autonoma de Mexico.
FAU - Aviles-Flores, Margarita
AU  - Aviles-Flores M
AD  - INAH-Morelos.
FAU - Fuentes-Mata, Macrina
AU  - Fuentes-Mata M
AD  - INAH-Morelos.
FAU - Jimenez-Ferrer, Enrique
AU  - Jimenez-Ferrer E
AD  - Centro de Investigacion Biomedica del Sur, Instituto Mexicano del Seguro Social 
      (IMSS).
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Cinnamates)
RN  - 0 (Cytokines)
RN  - 0 (Depsides)
RN  - 0 (Plant Extracts)
RN  - 11128-99-7 (Angiotensin II)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Angiotensin II/pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Cinnamates/*pharmacology
MH  - Corticosterone/blood
MH  - Cytokines/metabolism
MH  - Depsides/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Hypertension/chemically induced/*drug therapy/metabolism
MH  - Hypothalamo-Hypophyseal System/drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Mice, Inbred ICR
MH  - Ocimum/*chemistry
MH  - Ocimum basilicum/chemistry
MH  - Pituitary-Adrenal System/drug effects
MH  - Plant Extracts/*pharmacology
MH  - Random Allocation
MH  - Spatial Navigation/drug effects
MH  - Rosmarinic Acid
OTO - NOTNLM
OT  - Ocimum basilicum
OT  - Ocimum selloi
OT  - angiotensin II
OT  - anxiety
OT  - inflammation
OT  - memory
EDAT- 2019/02/05 06:00
MHDA- 2019/07/10 06:00
CRDT- 2019/02/05 06:00
PHST- 2019/02/05 06:00 [entrez]
PHST- 2019/02/05 06:00 [pubmed]
PHST- 2019/07/10 06:00 [medline]
AID - 10.1248/bpb.b18-00574 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2019;42(2):201-211. doi: 10.1248/bpb.b18-00574.