PMID- 30713847
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231005
IS  - 2356-6981 (Print)
IS  - 2314-5749 (Electronic)
IS  - 2314-5749 (Linking)
VI  - 2019
DP  - 2019
TI  - Association of CCL2, CCR5, ELMO1, and IL8 Polymorphism with Diabetic Nephropathy 
      in Malaysian Type 2 Diabetic Patients.
PG  - 2053015
LID - 10.1155/2019/2053015 [doi]
LID - 2053015
AB  - The unique variants or biomarkers of individuals help to understand the 
      pathogenesis as well as the potential risk of individuals or patients to diabetic 
      nephropathy (DN). The aim of this study was to investigate the association of a 
      genetic polymorphism of monocyte chemoattractant protein-1 (CCL2-rs3917887), 
      chemokine receptor 5 (CCR5-rs1799987), engulfment and cell mortality 
      (ELMO1-rs74130), and interleukin-8 (IL8-rs4073) with the development of DN among 
      Malaysian type 2 diabetes mellitus (T2DM) patients. More than one thousand 
      diabetic patients were examined and a total of 652 T2DM patients were tested 
      comprising 227 Malays (nonnephrotic=96 and nephrotic=131), 203 Chinese 
      (nonnephrotic=95 and nephrotic=108), and 222 Indians (nonnephrotic=136 and 
      nephrotic=86). DNA Sequenom mass ARRAY was employed to identify polymorphisms in 
      CCL2, CCR5, ELMO1, and IL8 genes. DNA was extracted from the secondary blood 
      samples taken from the T2DM patients. The alleles and genotypes were tested using 
      four genetic models and the best mode of inheritance was chosen. CCR5 rs1799987 
      (G>A) showed strong association with the development of diabetic nephropathy only 
      among the Chinese with OR=6.71 (2.55-17.68) 95% CI while IL8 rs4073 (T>A) showed 
      association with nephropathy only among the Indians with OR=1.57 (0.66-3.71) 95% 
      CI. The additive model was the best model for the mode of inheritance of all the 
      genes. The contribution of genetic variants differs across ethnic groups or 
      background. Further studies which involve environmental risk factors should be 
      taken into consideration.
FAU - Yahya, Mohd Jokha
AU  - Yahya MJ
AUID- ORCID: 0000-0003-0391-8039
AD  - Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 
      Universiti Putra Malaysia, Malaysia.
FAU - Ismail, Patimah Binti
AU  - Ismail PB
AD  - Department of Human Development and Growth, Faculty of Medicine and Health 
      Sciences, Universiti Putra Malaysia, Malaysia.
FAU - Nordin, Norshariza Binti
AU  - Nordin NB
AUID- ORCID: 0000-0003-1019-0496
AD  - Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 
      Universiti Putra Malaysia, Malaysia.
FAU - Akim, Abdah Binti Md
AU  - Akim ABM
AD  - Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 
      Universiti Putra Malaysia, Malaysia.
FAU - Yusuf, Wan Shaariah Binti Md
AU  - Yusuf WSBM
AD  - Department of Medicine (Endocrinology & Nephrology), Hospital Tuanku Ja'afar, 
      Malaysia.
FAU - Adam, Noor Lita Binti
AU  - Adam NLB
AD  - Department of Medicine (Endocrinology & Nephrology), Hospital Tuanku Ja'afar, 
      Malaysia.
FAU - Yusoff, Maryam Jamielah
AU  - Yusoff MJ
AD  - Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 
      Universiti Putra Malaysia, Malaysia.
LA  - eng
PT  - Journal Article
DEP - 20190101
PL  - Egypt
TA  - Int J Chronic Dis
JT  - International journal of chronic diseases
JID - 101654921
PMC - PMC6333004
EDAT- 2019/02/05 06:00
MHDA- 2019/02/05 06:01
PMCR- 2019/01/01
CRDT- 2019/02/05 06:00
PHST- 2018/09/28 00:00 [received]
PHST- 2018/11/02 00:00 [revised]
PHST- 2018/12/13 00:00 [accepted]
PHST- 2019/02/05 06:00 [entrez]
PHST- 2019/02/05 06:00 [pubmed]
PHST- 2019/02/05 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.1155/2019/2053015 [doi]
PST - epublish
SO  - Int J Chronic Dis. 2019 Jan 1;2019:2053015. doi: 10.1155/2019/2053015. 
      eCollection 2019.