PMID- 30715139
OWN - NLM
STAT- MEDLINE
DCOM- 20200831
LR  - 20200831
IS  - 1527-330X (Electronic)
IS  - 1090-820X (Linking)
VI  - 39
IP  - 10
DP  - 2019 Sep 13
TI  - Differences in Human Leukocyte Antigen Expression Between Breast 
      Implant-Associated Anaplastic Large Cell Lymphoma Patients and the General 
      Population.
PG  - 1065-1070
LID - 10.1093/asj/sjz021 [doi]
AB  - BACKGROUND: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) 
      is an uncommon T-cell lymphoma associated with textured-surface breast implants. 
      Human leukocyte antigen (HLA) polymorphisms have been described with other forms 
      of lymphoma, but have not been described for BIA-ALCL. OBJECTIVES: The aim of 
      this study was to evaluate HLA polymorphisms in BIA-ALCL patients. METHODS: We 
      prospectively evaluated HLA alleles in patients with BIA-ALCL. HLA was analyzed 
      by probe-based sequence-specific testing and sequence-based typing. The 
      frequencies of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles were 
      evaluated. Allele frequencies in the Caucasian European general population were 
      obtained from the National Marrow Donor Program to serve as normative controls. 
      We estimated the relative risk of BIA-ALCL with 95% confidence intervals from a t 
      test. RESULTS: Thirteen patients who had undergone BIA-ALCL and HLA testing were 
      identified from 2017 to 2018. Patients carried 10, 11, and 9 HLA-A, HLA-B, and 
      HLA-C alleles, respectively. There were 8 DRB1 alleles and 5 DQB1 alleles in the 
      BIA-ALCL patients. The A*26 allele occurred significantly more frequently in the 
      general population compared with BIA-ALCL patients (0.2992 vs 0.07692, P < 
      0.001). CONCLUSIONS: Our results identify a difference between HLA A*26 in 
      patients who develop BIA-ALCL and the general population, and may signify genetic 
      susceptibility factors responsible for germline genetic variation in HLA in 
      patients with BIA-ALCL. Further work is needed to elucidate if these alleles are 
      predictive for BIA-ALCL in women with textured-surface breast implants.Level of 
      Evidence: 4.
CI  - (c) 2019 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and 
      permission: journals.permissions@oup.com.
FAU - Tevis, Sarah E
AU  - Tevis SE
AD  - Department of Surgery, University of Colorado, Aurora, CO.
FAU - Hunt, Kelly K
AU  - Hunt KK
AD  - Department of Breast Surgical Oncology, MD Anderson Cancer Center, Houston, TX.
FAU - Miranda, Roberto N
AU  - Miranda RN
AD  - Department of Hematopathology, MD Anderson Cancer Center, Houston, TX.
FAU - Lange, Caitlin
AU  - Lange C
AD  - Department of Plastic Surgery, MD Anderson Cancer Center, Houston, TX.
FAU - Butler, Charles E
AU  - Butler CE
AD  - Department of Plastic Surgery, MD Anderson Cancer Center, Houston, TX.
FAU - Clemens, Mark W
AU  - Clemens MW
AD  - Department of Plastic Surgery, MD Anderson Cancer Center, Houston, TX.
AD  - Breast Surgery Section Co-editor for Aesthetic Surgery Journal.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Aesthet Surg J
JT  - Aesthetic surgery journal
JID - 9707469
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Bone Marrow/pathology
MH  - Breast/pathology/surgery
MH  - Breast Implantation/*adverse effects/instrumentation
MH  - Breast Implants/*adverse effects
MH  - Breast Neoplasms/surgery
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotyping Techniques
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Lymphoma, Large-Cell, Anaplastic/diagnosis/etiology/*genetics/pathology
MH  - Mastectomy/adverse effects
MH  - Middle Aged
MH  - Prospective Studies
MH  - Surface Properties
EDAT- 2019/02/05 06:00
MHDA- 2020/09/01 06:00
CRDT- 2019/02/05 06:00
PHST- 2019/02/05 06:00 [pubmed]
PHST- 2020/09/01 06:00 [medline]
PHST- 2019/02/05 06:00 [entrez]
AID - 5306130 [pii]
AID - 10.1093/asj/sjz021 [doi]
PST - ppublish
SO  - Aesthet Surg J. 2019 Sep 13;39(10):1065-1070. doi: 10.1093/asj/sjz021.