PMID- 30715647
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2191-219X (Print)
IS  - 2191-219X (Electronic)
IS  - 2191-219X (Linking)
VI  - 9
IP  - 1
DP  - 2019 Feb 4
TI  - Partial-volume correction in dynamic PET-CT: effect on tumor kinetic parameter 
      estimation and validation of simplified metrics.
PG  - 12
LID - 10.1186/s13550-019-0483-z [doi]
LID - 12
AB  - BACKGROUND: Partial-volume effects generally result in an underestimation of 
      tumor tracer uptake on PET-CT for small lesions, necessitating partial-volume 
      correction (PVC) for accurate quantification. However, investigation of PVC in 
      dynamic oncological PET studies to date is scarce. The aim of this study was to 
      investigate PVC's impact on tumor kinetic parameter estimation from dynamic 
      PET-CT acquisitions and subsequent validation of simplified semi-quantitative 
      metrics. Ten patients with EGFR-mutated non-small cell lung cancer underwent 
      dynamic (18)F-fluorothymidine PET-CT before, 7 days after, and 28 days after 
      commencing treatment with a tyrosine kinase inhibitor. Parametric PVC was applied 
      using iterative deconvolution without and with highly constrained backprojection 
      (HYPR) denoising, respectively. Using an image-derived input function with venous 
      parent plasma calibration, we estimated full kinetic parameters V(T), K(1), and 
      k(3)/k(4) (BP(ND)) using a reversible two-tissue compartment model, and 
      simplified metrics (SUV and tumor-to-blood ratio) at 50-60 min post-injection. 
      RESULTS: PVC had a non-linear effect on measured activity concentrations per 
      timeframe. PVC significantly changed each kinetic parameter, with a median 
      increase in V(T) of 11.8% (up to 25.1%) and 10.8% (up to 21.7%) without and with 
      HYPR, respectively. Relative changes in kinetic parameter estimates vs. 
      simplified metrics after applying PVC were poorly correlated (correlations 
      0.36-0.62; p < 0.01). PVC increased correlations between simplified metrics and 
      V(T) from 0.82 and 0.81 (p < 0.01) to 0.90 and 0.88 (p < 0.01) for SUV and TBR, 
      respectively, albeit non-significantly. PVC also increased correlations between 
      treatment-induced changes in simplified metrics vs. V(T) at 7 (SUV) and 28 (SUV 
      and TBR) days after treatment start non-significantly. Delineation on 
      partial-volume corrected PET images resulted in a median decrease in metabolic 
      tumor volume of 14.3% (IQR - 22.1 to - 7.5%), and increased the effect of PVC on 
      kinetic parameter estimates. CONCLUSION: PVC has a significant impact on tumor 
      kinetic parameter estimation from dynamic PET-CT data, which differs from its 
      effect on simplified metrics. However, it affected validation of these simplified 
      metrics both as single measurements and as biomarkers of treatment response only 
      to a small extent. Future dynamic PET studies should preferably incorporate PVC. 
      TRIAL REGISTRATION: Dutch Trial Register, NTR3557 .
FAU - Cysouw, M C F
AU  - Cysouw MCF
AUID- ORCID: 0000-0001-5946-0173
AD  - Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit 
      Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the 
      Netherlands. m.cysouw@vumc.nl.
FAU - Golla, S V S
AU  - Golla SVS
AD  - Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit 
      Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the 
      Netherlands.
FAU - Frings, V
AU  - Frings V
AD  - Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit 
      Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the 
      Netherlands.
FAU - Smit, E F
AU  - Smit EF
AD  - Department of Thoracic Oncology, Netherlands Cancer Institute, Plesmanlaan 121, 
      Amsterdam, the Netherlands.
FAU - Hoekstra, O S
AU  - Hoekstra OS
AD  - Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit 
      Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the 
      Netherlands.
FAU - Kramer, G M
AU  - Kramer GM
AD  - Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit 
      Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the 
      Netherlands.
FAU - Boellaard, R
AU  - Boellaard R
AD  - Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit 
      Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the 
      Netherlands.
CN  - QuIC-ConCePT Consortium
LA  - eng
GR  - 115151/Innovative Medicines Initiative/
PT  - Journal Article
DEP - 20190204
PL  - Germany
TA  - EJNMMI Res
JT  - EJNMMI research
JID - 101560946
PMC - PMC6362178
OTO - NOTNLM
OT  - Dynamic PET-CT
OT  - Kinetic parameter estimation
OT  - Oncology
OT  - Partial-volume correction
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: This study was approved by the 
      medical ethical committee of the Amsterdam UMC (location VUmc), and all 
      participants provided informed consent for study participation. CONSENT FOR 
      PUBLICATION: Each participant provided consent for data publication. COMPETING 
      INTERESTS: The authors declare that they have no competing interests. PUBLISHER'S 
      NOTE: Springer Nature remains neutral with regard to jurisdictional claims in 
      published maps and institutional affiliations.
EDAT- 2019/02/05 06:00
MHDA- 2019/02/05 06:01
PMCR- 2019/02/04
CRDT- 2019/02/05 06:00
PHST- 2018/11/29 00:00 [received]
PHST- 2019/01/25 00:00 [accepted]
PHST- 2019/02/05 06:00 [entrez]
PHST- 2019/02/05 06:00 [pubmed]
PHST- 2019/02/05 06:01 [medline]
PHST- 2019/02/04 00:00 [pmc-release]
AID - 10.1186/s13550-019-0483-z [pii]
AID - 483 [pii]
AID - 10.1186/s13550-019-0483-z [doi]
PST - epublish
SO  - EJNMMI Res. 2019 Feb 4;9(1):12. doi: 10.1186/s13550-019-0483-z.