PMID- 30715770
OWN - NLM
STAT- MEDLINE
DCOM- 20190412
LR  - 20190412
IS  - 1442-200X (Electronic)
IS  - 1328-8067 (Linking)
VI  - 61
IP  - 3
DP  - 2019 Mar
TI  - High mobility group box 1 and markers of oxidative stress in human cord blood.
PG  - 264-270
LID - 10.1111/ped.13795 [doi]
AB  - BACKGROUND: Parturition induces considerable oxidative stress and many 
      inflammatory mediators, such as high mobility group box 1 (HMGB1), are involved 
      from the beginning of the pregnancy to birth. The aim of the present study was to 
      evaluate serum cord blood concentration of diacron-reactive oxygen metabolites 
      (d-ROM), biological antioxidant potential (BAP), and HMGB1 to investigate the 
      perinatal oxidative status of neonates and correlation with mode of delivery, as 
      well as the influence of labor. METHODS: The subjects consisted of 214 neonates 
      delivered at University Hospital "G. Martino", Messina, in a 6 months period. 
      Venous blood samples were collected from the umbilical cord after cord 
      separation. RESULTS: Umbilical cord venous blood HMGB1 was significantly higher 
      in the spontaneous vaginal delivery (SVD) group than in the elective or emergency 
      cesarean section (CS) group (P = 0.018). Regarding labor, there was no 
      significant difference in HMGB1 concentration in umbilical vein blood between the 
      spontaneous and induced labor groups (P = 0.250). Furthermore, d-ROM was 
      significantly different between the SVD group and the elective or emergency CS 
      group (P = 0.044). BAP concentration, however, was not significantly different, 
      not even with regard to mode of labor. CONCLUSION: Oxidation is higher in 
      newborns delivered by SVD than in those delivered by CS, and HMGB1 may be 
      involved in the mechanisms of birth, and responsible for decidual modifications 
      that lead to birth.
CI  - (c) 2019 Japan Pediatric Society.
FAU - D'Angelo, Gabriella
AU  - D'Angelo G
AUID- ORCID: 0000-0003-3038-1759
AD  - Department of Clinical and Experimental Medicine, University of Messina, Messina, 
      Italy.
AD  - Neonatal Intensive Care Unit, Gaetano Barresi Department of Human Pathology in 
      Adult and Developmental Age, University of Messina, Messina, Italy.
FAU - Granese, Roberta
AU  - Granese R
AD  - Obstetrics and Gynecology Unit, Gaetano Barresi Department of Human Pathology in 
      Adult and Developmental Age, University of Messina, Messina, Italy.
FAU - Marseglia, Lucia
AU  - Marseglia L
AD  - Neonatal Intensive Care Unit, Gaetano Barresi Department of Human Pathology in 
      Adult and Developmental Age, University of Messina, Messina, Italy.
FAU - Impellizzeri, Pietro
AU  - Impellizzeri P
AD  - Unit of Paediatric Surgery, Gaetano Barresi Department of Human Pathology in 
      Adult and Developmental Age, University of Messina, Messina, Italy.
FAU - Alibrandi, Angela
AU  - Alibrandi A
AD  - Department of Economical, Business and Environmental Sciences and Quantitative 
      Methods, University of Messina, Messina, Italy.
FAU - Palmara, Antonella
AU  - Palmara A
AD  - Neonatal Intensive Care Unit, Gaetano Barresi Department of Human Pathology in 
      Adult and Developmental Age, University of Messina, Messina, Italy.
FAU - La Rosa, Maria Angela
AU  - La Rosa MA
AD  - Unit of Paediatric Genetics and Immunology, Gaetano Barresi Department of Human 
      Pathology in Adult and Developmental Age, University of Messina, Messina, Italy.
FAU - Manti, Sara
AU  - Manti S
AD  - Unit of Paediatric Genetics and Immunology, Gaetano Barresi Department of Human 
      Pathology in Adult and Developmental Age, University of Messina, Messina, Italy.
FAU - Salpietro, Carmelo
AU  - Salpietro C
AD  - Unit of Paediatric Genetics and Immunology, Gaetano Barresi Department of Human 
      Pathology in Adult and Developmental Age, University of Messina, Messina, Italy.
FAU - Spina, Edoardo
AU  - Spina E
AD  - Department of Clinical and Experimental Medicine, University of Messina, Messina, 
      Italy.
FAU - Reiter, Russel J
AU  - Reiter RJ
AD  - Department of Cell Systems and Anatomy, University of Texas Health Science 
      Center, San Antonio, Texas, USA.
FAU - Falsaperla, Raffaele
AU  - Falsaperla R
AD  - General Pediatrics and Pediatric Acute and Emergency Unit, 
      Policlinico-Vittorio-Emanuele University Hospital, University of Catania, 
      Catania, Italy.
FAU - Corsello, Giovanni
AU  - Corsello G
AD  - Department of Maternal and Child Health, University of Palermo, Palermo, Italy.
FAU - Gitto, Eloisa
AU  - Gitto E
AD  - Neonatal Intensive Care Unit, Gaetano Barresi Department of Human Pathology in 
      Adult and Developmental Age, University of Messina, Messina, Italy.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Pediatr Int
JT  - Pediatrics international : official journal of the Japan Pediatric Society
JID - 100886002
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (HMGB1 Protein)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Antioxidants/metabolism
MH  - Biomarkers/blood
MH  - Delivery, Obstetric/*statistics & numerical data
MH  - Female
MH  - Fetal Blood/*metabolism
MH  - HMGB1 Protein/*blood
MH  - Humans
MH  - Infant, Newborn
MH  - Italy
MH  - Labor, Obstetric/metabolism/physiology
MH  - Oxidative Stress/*physiology
MH  - Pregnancy
MH  - Reactive Oxygen Species/metabolism
OTO - NOTNLM
OT  - cord blood
OT  - high mobility group box 1
OT  - newborn
OT  - oxidative stress
OT  - pregnancy
EDAT- 2019/02/05 06:00
MHDA- 2019/04/13 06:00
CRDT- 2019/02/05 06:00
PHST- 2018/09/18 00:00 [received]
PHST- 2019/01/31 00:00 [accepted]
PHST- 2019/02/05 06:00 [pubmed]
PHST- 2019/04/13 06:00 [medline]
PHST- 2019/02/05 06:00 [entrez]
AID - 10.1111/ped.13795 [doi]
PST - ppublish
SO  - Pediatr Int. 2019 Mar;61(3):264-270. doi: 10.1111/ped.13795.