PMID- 30715786
OWN - NLM
STAT- MEDLINE
DCOM- 20191120
LR  - 20191120
IS  - 1708-8208 (Electronic)
IS  - 1523-0899 (Linking)
VI  - 21
IP  - 2
DP  - 2019 Apr
TI  - Effects of micro/nano strontium-loaded surface implants on osseointegration in 
      ovariectomized sheep.
PG  - 377-385
LID - 10.1111/cid.12719 [doi]
AB  - BACKGROUND: Poor osseointegration of dental implants often occurs in osteoporotic 
      patients and processed implant surfaces could help to improve the dilemma. 
      PURPOSE: This study aimed to compare the effects of different titanium (Ti) 
      surfaces on bone-implant osseointegration in ovariectomized (OVX) sheep. 
      MATERIALS AND METHODS: Four groups were included: smooth titanium (ST) was merely 
      polished Ti; micro titanium (MT) was treated with hydrofluoric acid (HF) for 
      30 minutes; strontium-loaded nano titanium (NT-Sr) was formed by magnetron 
      sputtering; strontium-loaded micro/nano titanium (MNT-Sr) was fabricated by HF 
      etching combined with magnetron sputtering. The biological responses were 
      evaluated by human bone marrow-derived mesenchymal stem cells (hBMMSCs) 
      experiments in vitro. Osseointegration was evaluated in vivo after each surface 
      implant was inserted into OVX sheep' mandibles. RESULTS: The numbers of adhered 
      and mineralized hBMMSCs increased significantly in the MNT-Sr group. The 
      bone-implant contact and the maximal pull-out force increased significantly with 
      MNT-Sr surface. The bone volume ratio and trabecular number of the MNT-Sr group 
      were significantly higher than others, whereas trabecular separation decreased. 
      CONCLUSIONS: These results indicated that an MNT-Sr surface promotes the 
      differentiation of hBMMSCs in vitro and enhances bone-implant osseointegration in 
      vivo, which may be a promising option for clinical implants in osteoporotic 
      patients.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Liu, Fuwei
AU  - Liu F
AD  - State Key Laboratory of Military Stomatology and National Clinical Research 
      Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, 
      Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth 
      Military Medical University, Xi'an, People's Republic of China.
FAU - Li, Yongfeng
AU  - Li Y
AD  - Department of Stomatology, PLA 301 Hospital, Beijing, People's Republic of China.
FAU - Liang, Jianfei
AU  - Liang J
AD  - State Key Laboratory of Military Stomatology and National Clinical Research 
      Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, 
      Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth 
      Military Medical University, Xi'an, People's Republic of China.
FAU - Sui, Wen
AU  - Sui W
AD  - Department of Stomatology, Shenzhen Hospital of Southern Medical University, 
      Shenzhen, People's Republic of China.
FAU - Bellare, Anuj
AU  - Bellare A
AD  - Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, 
      Massachusetts.
FAU - Kong, Liang
AU  - Kong L
AUID- ORCID: 0000-0003-4960-1993
AD  - State Key Laboratory of Military Stomatology and National Clinical Research 
      Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, 
      Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth 
      Military Medical University, Xi'an, People's Republic of China.
LA  - eng
GR  - 81500901/National Natural Science Foundation of China/
GR  - 81670803/National Natural Science Foundation of China/
GR  - [2018]236/Entrepreneurial and Innovative Program of Shenzhen for Overseas 
      High-Level Talents/
GR  - 17BJZ14/Military Health Care Project of China/
PT  - Journal Article
DEP - 20190204
PL  - United States
TA  - Clin Implant Dent Relat Res
JT  - Clinical implant dentistry and related research
JID - 100888977
RN  - 0 (Dental Implants)
RN  - D1JT611TNE (Titanium)
RN  - YZS2RPE8LE (Strontium)
SB  - IM
MH  - Animals
MH  - *Dental Implants
MH  - Humans
MH  - Mandible
MH  - *Osseointegration
MH  - Sheep
MH  - Strontium
MH  - Surface Properties
MH  - Titanium
OTO - NOTNLM
OT  - implant surface
OT  - micro/nano rough
OT  - osteoporosis
OT  - strontium
EDAT- 2019/02/05 06:00
MHDA- 2019/11/21 06:00
CRDT- 2019/02/05 06:00
PHST- 2018/12/05 00:00 [received]
PHST- 2019/01/04 00:00 [accepted]
PHST- 2019/02/05 06:00 [pubmed]
PHST- 2019/11/21 06:00 [medline]
PHST- 2019/02/05 06:00 [entrez]
AID - 10.1111/cid.12719 [doi]
PST - ppublish
SO  - Clin Implant Dent Relat Res. 2019 Apr;21(2):377-385. doi: 10.1111/cid.12719. Epub 
      2019 Feb 4.