PMID- 30716813
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 32
IP  - 22
DP  - 2018 Nov
TI  - [Epigenetic regulations in laryngeal squamous cell carcinoma].
PG  - 1958-1762
LID - 10.13201/j.issn.1001-1781.2018.22.019 [doi]
AB  - Laryngeal cancer, which is mainly consisted of laryngeal squamous cell 
      carcinoma(LSCC), is one of the common neoplasms in head and neck. In spite the 
      advantages in diagnose and treatment, the mortality of LSCC is still high in the 
      past 20 years. Epigenetic regulations play a important role in LSCC. The aim of 
      this review is to provide an update on the epigenetic regulations in LSCC, such 
      as the methylation of chromatin, the pre- and post-regulation of transcription by 
      microRNAs and/or long noncoding RNAs. The gene methylation can represses the 
      expression of genes, and some histone and DNA methylation are associated with 
      LSCC. Histone deacetylases also play a role in LSCC. MicroRNAs are about 22 nt in 
      length, which inhibit or facilite the occurrence and development of LSCC by 
      different mechanisms.Long noncoding RNAs(lncRNAs) , more than 200 nt in length, 
      can modulate the LSCC in different levels, such as gene methylation modification, 
      microRNA regulation. Based on the differences of epigenetic regulation, some 
      characteristics may serve as markers of diagnose, and even facilitate the 
      treatment of LSCC.
CI  - Copyright(c) by the Editorial Department of Journal of Clinical Otorhinolaryngology 
      Head and Neck Surgery.
FAU - Meng, W X
AU  - Meng WX
FAU - Wang, B S
AU  - Wang BS
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
OTO - NOTNLM
OT  - DNA methylation
OT  - epigenetic regulation
OT  - laryngeal neoplasms
OT  - long noncoding RNA
OT  - microRNA
OT  - squamous cell carcinoma
COIS- The authors of this article and the planning committee members and staff have no 
      relevant financial relationships with commercial interests to disclose.
EDAT- 2019/02/06 06:00
MHDA- 2019/02/06 06:01
CRDT- 2019/02/06 06:00
PHST- 2018/02/02 00:00 [received]
PHST- 2019/02/06 06:00 [entrez]
PHST- 2019/02/06 06:00 [pubmed]
PHST- 2019/02/06 06:01 [medline]
AID - 10.13201/j.issn.1001-1781.2018.22.019 [doi]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Nov;32(22):1958-1762. doi: 
      10.13201/j.issn.1001-1781.2018.22.019.