PMID- 30717180
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 8
IP  - 2
DP  - 2019 Feb 1
TI  - Incremental Predictive Value of Longitudinal Axis Strain and Late Gadolinium 
      Enhancement Using Standard CMR Imaging in Patients with Aortic Stenosis.
LID - 10.3390/jcm8020165 [doi]
LID - 165
AB  - To analyse the predictive ability and incremental value of left ventricular 
      longitudinal axis strain (LAS) and late gadolinium enhancement (LGE) using 
      standard cardiovascular magnetic resonance (CMR) imaging for the diagnosis and 
      prognosis of severe aortic stenosis (AS) in patients with an indication for 
      aortic valve replacement. We conducted a prospective study on 52 patients with 
      severe AS and 52 volunteers. The evaluation protocol included standard 
      biochemistry tests, novel biomarkers of myocardial fibrosis, 12-lead 
      electrocardiograms and 24-hour Holter, the 6-minute walk test and extensive 
      echocardiographic and CMR imaging studies. Outcomes were defined as the composite 
      of major cardiovascular events (MACEs). Among AS patients, most (n = 17, 77.2%) 
      of those who exhibited LGE at CMR imaging had MACEs during follow-up. 
      Kaplan(-)Meier curves for event-free survival showed a significantly higher rate of 
      MACEs in patients with LGE (p < 0.01) and decreased LAS (p < 0.001). In Cox 
      regression analysis, only reduced LAS (hazard ratio 1.33, 95% CI (1.01 to 1.74), 
      p < 0.01) and the presence of LGE (hazard ratio 11.3, 95% CI (1.82 to 70.0), p < 
      0.01) were independent predictors for MACEs. The predictive value increased if 
      both LGE and reduced LAS were added to left ventricular ejection fraction (LVEF). 
      None of the biomarkers of increased collagen turnover exhibited any predictive 
      value for MACEs. LAS by CMR is an independent predictor of outcomes in patients 
      with AS and provides incremental value beyond the assessment of LVEF and the 
      presence of LGE.
FAU - Agoston-Coldea, Lucia
AU  - Agoston-Coldea L
AD  - 2nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400006 Cluj-Napoca, Romania. luciacoldea@yahoo.com.
AD  - Affidea Hiperdia Diagnostic Imaging Center, 400015 Cluj-Napoca, Romania. 
      luciacoldea@yahoo.com.
FAU - Bheecarry, Kunal
AU  - Bheecarry K
AD  - 2nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400006 Cluj-Napoca, Romania. kunalvarmab@gmail.com.
FAU - Cionca, Carmen
AU  - Cionca C
AD  - Affidea Hiperdia Diagnostic Imaging Center, 400015 Cluj-Napoca, Romania. 
      carmen.cionca@hiperdia.ro.
FAU - Petra, Cristian
AU  - Petra C
AD  - 2nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400006 Cluj-Napoca, Romania. cristian.petra@gmail.com.
FAU - Strimbu, Lelia
AU  - Strimbu L
AD  - Niculae Stancioiu Heart Institute, 400001 Cluj-Napoca, Romania. 
      lstrimbu@yahoo.com.
FAU - Ober, Camelia
AU  - Ober C
AD  - Niculae Stancioiu Heart Institute, 400001 Cluj-Napoca, Romania. 
      cami.ober@yahoo.com.
FAU - Lupu, Silvia
AU  - Lupu S
AD  - 5th Department of Internal Medicine, University of Medicine and Pharmacy of Tirgu 
      Mures, 540139 Tirgu Mures, Romania. sil_lupu@yahoo.com.
FAU - Fodor, Daniela
AU  - Fodor D
AD  - 2nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400006 Cluj-Napoca, Romania. dfodor@umfcluj.com.
FAU - Mocan, Teodora
AU  - Mocan T
AUID- ORCID: 0000-0001-9925-0998
AD  - Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, 
      400006 Cluj-Napoca, Romania. teodora_mocan@yahoo.com.
LA  - eng
GR  - Grant no. 4994/1/2016/from the Iuliu Hatieganu University of Medicine and 
      Pharmacy of Cluj-Napoca./
PT  - Journal Article
DEP - 20190201
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC6406708
OTO - NOTNLM
OT  - cardiac magnetic resonance imaging
OT  - late gadolinium enhancement
OT  - longitudinal axis strain
OT  - severe aortic stenosis
COIS- The authors declare no conflict of interest.
EDAT- 2019/02/06 06:00
MHDA- 2019/02/06 06:01
PMCR- 2019/02/01
CRDT- 2019/02/06 06:00
PHST- 2018/12/26 00:00 [received]
PHST- 2019/01/22 00:00 [revised]
PHST- 2019/01/30 00:00 [accepted]
PHST- 2019/02/06 06:00 [entrez]
PHST- 2019/02/06 06:00 [pubmed]
PHST- 2019/02/06 06:01 [medline]
PHST- 2019/02/01 00:00 [pmc-release]
AID - jcm8020165 [pii]
AID - jcm-08-00165 [pii]
AID - 10.3390/jcm8020165 [doi]
PST - epublish
SO  - J Clin Med. 2019 Feb 1;8(2):165. doi: 10.3390/jcm8020165.