PMID- 30717427
OWN - NLM
STAT- MEDLINE
DCOM- 20190225
LR  - 20200225
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 11
IP  - 2
DP  - 2019 Feb 2
TI  - Binge-Type Eating in Rats is Facilitated by Neuromedin U Receptor 2 in the 
      Nucleus Accumbens and Ventral Tegmental Area.
LID - 10.3390/nu11020327 [doi]
LID - 327
AB  - Binge-eating disorder (BED) is the most common eating disorder, characterized by 
      rapid, recurrent overconsumption of highly palatable food in a short time frame. 
      BED shares an overlapping behavioral phenotype with obesity, which is also linked 
      to the overconsumption of highly palatable foods. The reinforcing properties of 
      highly palatable foods are mediated by the nucleus accumbens (NAc) and the 
      ventral tegmental area (VTA), which have been implicated in the overconsumption 
      behavior observed in BED and obesity. A potential regulator of binge-type eating 
      behavior is the G protein-coupled receptor neuromedin U receptor 2 (NMUR2). 
      Previous research demonstrated that NMUR2 knockdown potentiates binge-type 
      consumption of high-fat food. We correlated binge-type consumption across a 
      spectrum of fat and carbohydrate mixtures with synaptosomal NMUR2 protein 
      expression in the NAc and VTA of rats. Synaptosomal NMUR2 protein in the NAc 
      demonstrated a strong positive correlation with binge intake of a "lower"-fat 
      (higher carbohydrate) mixture, whereas synaptosomal NMUR2 protein in the VTA 
      demonstrated a strong negative correlation with binge intake of an "extreme" 
      high-fat (0% carbohydrate) mixture. Taken together, these data suggest that NMUR2 
      may differentially regulate binge-type eating within the NAc and the VTA.
FAU - Smith, Ashley E
AU  - Smith AE
AD  - Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 
      77555, USA. aesmith@utmb.edu.
AD  - Department of Neuroscience, Cell Biology and Anatomy, University of Texas Medical 
      Branch, Galveston, TX 77555, USA. aesmith@utmb.edu.
FAU - Kasper, James M
AU  - Kasper JM
AUID- ORCID: 0000-0003-0169-2603
AD  - Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 
      77555, USA. jakasper@utmb.edu.
AD  - Department of Pharmacology and Toxicology, University of Texas Medical Branch, 
      Galveston, TX 77555, USA. jakasper@utmb.edu.
CN  - Ara 13
AD  - Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 
      77555, USA. ara13c@gmail.com.
FAU - Anastasio, Noelle C
AU  - Anastasio NC
AD  - Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 
      77555, USA. ncanasta@utmb.edu.
AD  - Department of Pharmacology and Toxicology, University of Texas Medical Branch, 
      Galveston, TX 77555, USA. ncanasta@utmb.edu.
FAU - Hommel, Jonathan D
AU  - Hommel JD
AUID- ORCID: 0000-0001-8305-3746
AD  - Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 
      77555, USA. jdhommel@utmb.edu.
AD  - Department of Neuroscience, Cell Biology and Anatomy, University of Texas Medical 
      Branch, Galveston, TX 77555, USA. jdhommel@utmb.edu.
AD  - Department of Pharmacology and Toxicology, University of Texas Medical Branch, 
      Galveston, TX 77555, USA. jdhommel@utmb.edu.
LA  - eng
GR  - R01DK106229/DK/NIDDK NIH HHS/United States
GR  - T32DA07287/DA/NIDA NIH HHS/United States
GR  - KL2TR001441/TR/NCATS NIH HHS/United States
GR  - R01 DK106229/DK/NIDDK NIH HHS/United States
GR  - UL1 TR001439/TR/NCATS NIH HHS/United States
GR  - T32 DA007287/DA/NIDA NIH HHS/United States
GR  - UL1TR001439/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20190202
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Neuropeptides)
RN  - 0 (Receptors, Neurotransmitter)
RN  - 0 (neuromedin U receptor)
RN  - 117505-80-3 (neuromedin U)
SB  - IM
MH  - Animals
MH  - Binge-Eating Disorder/*metabolism/psychology
MH  - Bulimia/*metabolism/psychology
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/administration & dosage
MH  - Eating/psychology
MH  - Energy Intake/physiology
MH  - Feeding Behavior/*physiology/psychology
MH  - Male
MH  - Neuropeptides/*metabolism
MH  - Nucleus Accumbens/*metabolism
MH  - Obesity/psychology
MH  - Rats, Sprague-Dawley
MH  - Receptors, Neurotransmitter/*metabolism
MH  - Ventral Tegmental Area/*metabolism
PMC - PMC6412951
OTO - NOTNLM
OT  - BED
OT  - NMUR2
OT  - binge-eating disorder
OT  - binge-type eating
OT  - neuromedin U receptor 2
OT  - nucleus accumbens
OT  - obesity
OT  - ventral tegmental area
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2019/02/06 06:00
MHDA- 2019/02/26 06:00
PMCR- 2019/02/01
CRDT- 2019/02/06 06:00
PHST- 2018/12/20 00:00 [received]
PHST- 2019/01/29 00:00 [revised]
PHST- 2019/01/30 00:00 [accepted]
PHST- 2019/02/06 06:00 [entrez]
PHST- 2019/02/06 06:00 [pubmed]
PHST- 2019/02/26 06:00 [medline]
PHST- 2019/02/01 00:00 [pmc-release]
AID - nu11020327 [pii]
AID - nutrients-11-00327 [pii]
AID - 10.3390/nu11020327 [doi]
PST - epublish
SO  - Nutrients. 2019 Feb 2;11(2):327. doi: 10.3390/nu11020327.