PMID- 30717466
OWN - NLM
STAT- MEDLINE
DCOM- 20190529
LR  - 20200225
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 24
IP  - 3
DP  - 2019 Feb 3
TI  - Hypoglycemic Effects of Oat Oligopeptides in High-Calorie Diet/STZ-Induced 
      Diabetic Rats.
LID - 10.3390/molecules24030558 [doi]
LID - 558
AB  - The study was aimed to determine whether treatment with oat oligopeptides (OOPs) 
      could modulate hyperglycemia related to type 2 diabetes mellitus (T2DM) in 
      Sprague(-)Dawley (SD) rats. Diabetic SD rats modeling by a joint effect of 
      high-calorie diet for 45 days and twice intraperitoneal injection of 30 mg/kg 
      streptozotocin at one-week interval were observed with or without OOPs 
      administration (0.25, 0.50, 1.00, and 2.00 g/kg Body Weight) for 12 weeks. 
      Fasting blood glucose (FBG), oral glucose test tolerance (OGTT), serum insulin, 
      level of antioxidant, and hepatic enzymes were measured. In addition, frequency 
      of micturition was recorded in this study for the first time. It was observed 
      that the administration of OOPs (2.00 g/kg Body Weight) resulted in a significant 
      decrease (p < 0.05) in FBG since 6th week and a significant decrease (p < 0.05) 
      in the OGTT-AUC on 6th and 10th week. In addition, the administration of OOPs 
      (2.00 g/kg Body Weight) reduced HOMA-IR index and 24-h urine volume significantly 
      (p < 0.05) whereas increased SOD activity significantly (p < 0.05). These results 
      suggested that OOPs may have a hypoglycemic effect in diabetic rats.
FAU - Wang, Jun-Bo
AU  - Wang JB
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. bmuwjbxy@bjmu.edu.cn.
FAU - Liu, Xin-Ran
AU  - Liu XR
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. liuhappy07@163.com.
FAU - Liu, Si-Qi
AU  - Liu SQ
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. lsqdeyouxiang@126.com.
FAU - Mao, Rui-Xue
AU  - Mao RX
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. maoruixue@163.com.
FAU - Hou, Chao
AU  - Hou C
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. houchao_HC@163.com.
FAU - Zhu, Na
AU  - Zhu N
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. summer920503@163.com.
FAU - Liu, Rui
AU  - Liu R
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. liuruipku@163.com.
FAU - Ma, Hui-Juan
AU  - Ma HJ
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. mhjmhjmhj717@163.com.
FAU - Li, Yong
AU  - Li Y
AUID- ORCID: 0000-0003-3914-5840
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100191, China. liyongbmu@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190203
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Oligopeptides)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Avena/*chemistry
MH  - Biomarkers
MH  - Blood Glucose/drug effects
MH  - Body Weight/drug effects
MH  - Diabetes Mellitus, Experimental/drug therapy/*etiology/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Glucose Tolerance Test
MH  - Hypoglycemic Agents/chemistry/*pharmacology
MH  - Insulin/metabolism
MH  - Kidney Function Tests
MH  - Liver Function Tests
MH  - Oligopeptides/chemistry/*pharmacology
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Rats
PMC - PMC6384573
OTO - NOTNLM
OT  - hypoglycemic effect
OT  - oat oligopeptides
OT  - oral glucose tolerance test
COIS- The authors declare no conflict of interest.
EDAT- 2019/02/06 06:00
MHDA- 2019/05/30 06:00
PMCR- 2019/02/03
CRDT- 2019/02/06 06:00
PHST- 2018/11/30 00:00 [received]
PHST- 2019/01/11 00:00 [revised]
PHST- 2019/02/01 00:00 [accepted]
PHST- 2019/02/06 06:00 [entrez]
PHST- 2019/02/06 06:00 [pubmed]
PHST- 2019/05/30 06:00 [medline]
PHST- 2019/02/03 00:00 [pmc-release]
AID - molecules24030558 [pii]
AID - molecules-24-00558 [pii]
AID - 10.3390/molecules24030558 [doi]
PST - epublish
SO  - Molecules. 2019 Feb 3;24(3):558. doi: 10.3390/molecules24030558.