PMID- 30718140 OWN - NLM STAT- MEDLINE DCOM- 20191211 LR - 20191217 IS - 1590-3729 (Electronic) IS - 0939-4753 (Linking) VI - 29 IP - 3 DP - 2019 Mar TI - 6-year change in resting heart rate is associated with incident type 2 diabetes mellitus. PG - 236-243 LID - S0939-4753(18)30359-4 [pii] LID - 10.1016/j.numecd.2018.12.003 [doi] AB - BACKGROUND AND AIMS: Elevated resting heart rate (RHR) is associated with risk of type 2 diabetes mellitus (T2DM). However, the association of change in RHR (DeltaRHR) and incident T2DM is not fully elucidated. We aimed to assess the dose-response association between 6-year DeltaRHR and T2DM. METHODS AND RESULTS: A total of 12155 non-T2DM participants >/=18 years old were enrolled during 2007-2008 and followed up during 2013-2014. DeltaRHR was calculated by subtracting the baseline RHR from the RHR value at 6-year follow-up. Age-, sex-, and RHR-specific relative risks (RRs) and 95% confidence intervals (CIs) for the effect of DeltaRHR on incident T2DM were calculated by using modified Poisson regression models. As compared with DeltaRHR of 0 beats/min, the adjusted risk of T2DM was significantly increased with RHR increment and reduced with RHR reduction. DeltaRHR was positively associated with future risk of T2DM [RR per unit increase: 1.03 (1.03-1.04)]. As compared with stable change in RHR group (-5/=10 beats/min groups, the pooled adjusted RR (95% CI) of T2DM was 0.69 (0.55-0.86), 0.90 (0.73-1.11), 1.31 (1.07-1.61), and 1.90 (1.59-2.26), respectively. This significant association still existed on subgroup analyses based on age, sex, and baseline RHR and sensitivity analyses. CONCLUSIONS: Dynamic RHR change was significantly associated with incident T2DM. Our study suggests that RHR may be a non-invasive clinical indicator for interventions aiming to reduce incident T2DM in the general population. CI - Copyright (c) 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. FAU - Zhao, Y AU - Zhao Y AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Zhang, M AU - Zhang M AD - Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Liu, Y AU - Liu Y AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Yin, Z AU - Yin Z AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Li, H AU - Li H AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Sun, H AU - Sun H AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Henan, People's Republic of China. FAU - Wang, C AU - Wang C AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Henan, People's Republic of China. FAU - Ren, Y AU - Ren Y AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Liu, D AU - Liu D AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Henan, People's Republic of China. FAU - Cheng, C AU - Cheng C AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Henan, People's Republic of China. FAU - Liu, F AU - Liu F AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Chen, X AU - Chen X AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Liu, L AU - Liu L AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Zhou, Q AU - Zhou Q AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Xiong, Y AU - Xiong Y AD - Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Xu, Q AU - Xu Q AD - Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Liu, J AU - Liu J AD - Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Hong, S AU - Hong S AD - Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - You, Z AU - You Z AD - Department of Clinical Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. FAU - Li, J AU - Li J AD - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. FAU - Cao, J AU - Cao J AD - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. FAU - Huang, J AU - Huang J AD - Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. FAU - Sun, X AU - Sun X AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. Electronic address: sunxz632@126.com. FAU - Hu, D AU - Hu D AD - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. Electronic address: hud@szu.edu.cn. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20181214 PL - Netherlands TA - Nutr Metab Cardiovasc Dis JT - Nutrition, metabolism, and cardiovascular diseases : NMCD JID - 9111474 SB - IM MH - Adolescent MH - Adult MH - China/epidemiology MH - Diabetes Mellitus, Type 2/diagnosis/*epidemiology/physiopathology MH - Female MH - *Heart Rate MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Prognosis MH - Prospective Studies MH - *Rest MH - Risk Assessment MH - Risk Factors MH - Time Factors MH - Young Adult OTO - NOTNLM OT - Epidemiology OT - Prospective cohort study OT - Resting heart rate OT - Type 2 diabetes mellitus EDAT- 2019/02/06 06:00 MHDA- 2019/12/18 06:00 CRDT- 2019/02/06 06:00 PHST- 2018/08/25 00:00 [received] PHST- 2018/11/13 00:00 [revised] PHST- 2018/12/07 00:00 [accepted] PHST- 2019/02/06 06:00 [pubmed] PHST- 2019/12/18 06:00 [medline] PHST- 2019/02/06 06:00 [entrez] AID - S0939-4753(18)30359-4 [pii] AID - 10.1016/j.numecd.2018.12.003 [doi] PST - ppublish SO - Nutr Metab Cardiovasc Dis. 2019 Mar;29(3):236-243. doi: 10.1016/j.numecd.2018.12.003. Epub 2018 Dec 14.