PMID- 30718745
OWN - NLM
STAT- MEDLINE
DCOM- 20200825
LR  - 20200825
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Feb 4
TI  - UVA-activated riboflavin promotes collagen crosslinking to prevent root caries.
PG  - 1252
LID - 10.1038/s41598-018-38137-7 [doi]
LID - 1252
AB  - Root caries is an increasingly problem in aging societies with severe 
      implications for the general health and wellbeing of large numbers of people. 
      Strengthening type-I collagen, a major organic component of human dentin, has 
      proved effective in preventing root caries. This study sought to determine 
      whether exposure to riboflavin followed by UVA irradiation (RF/UVA) could promote 
      additional collagen crosslinking, and thus improve the acid and enzymatic 
      resistance of human dentin under simulated oral environments. If so, it could 
      offer potential for treatment of the intractable problem of root caries. The 
      greatest flexural strengths were found in dentin exposed to a 0.1% riboflavin 
      solution for 1 minute followed by 1,600 mW/cm(2) UVA irradiation for 10 minutes. 
      Mineral loss and lesion depth were significantly lower in the RF/UVA group than 
      in the control group. The microstructures of dentinal tubules and collagen 
      networks after RF/UVA treatment retained their original forms after acidic and 
      enzymatic degradation. In conclusion, RF/UVA treatment may be a new method for 
      preventing root caries with promising prospects for clinical application.
FAU - Uemura, R
AU  - Uemura R
AD  - Department of Restorative Dentistry and Endodontology, Graduate School of 
      Dentistry, Osaka University, Osaka, Japan. uemura@dent.osaka-u.ac.jp.
FAU - Miura, J
AU  - Miura J
AD  - Division for Interdisciplinary Dentistry, Graduate School of Dentistry, Osaka 
      University, Osaka, Japan.
FAU - Ishimoto, T
AU  - Ishimoto T
AD  - Division of Materials and Manufacturing Science, Graduate School of Engineering, 
      Osaka University, Osaka, Japan.
FAU - Yagi, K
AU  - Yagi K
AD  - Department of Restorative Dentistry and Endodontology, Graduate School of 
      Dentistry, Osaka University, Osaka, Japan.
FAU - Matsuda, Y
AU  - Matsuda Y
AD  - Division of Clinical Cariology and Endodontology, Graduate School of Dentistry, 
      Health Sciences University of Hokkaido, Hokkaido, Japan.
FAU - Shimizu, M
AU  - Shimizu M
AD  - Division for Interdisciplinary Dentistry, Graduate School of Dentistry, Osaka 
      University, Osaka, Japan.
FAU - Nakano, T
AU  - Nakano T
AUID- ORCID: 0000-0001-8052-1698
AD  - Division of Materials and Manufacturing Science, Graduate School of Engineering, 
      Osaka University, Osaka, Japan.
FAU - Hayashi, M
AU  - Hayashi M
AD  - Department of Restorative Dentistry and Endodontology, Graduate School of 
      Dentistry, Osaka University, Osaka, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190204
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 9007-34-5 (Collagen)
RN  - TLM2976OFR (Riboflavin)
SB  - IM
MH  - Collagen/*metabolism
MH  - Dentin/metabolism
MH  - Humans
MH  - Riboflavin/*pharmacology
MH  - Root Caries/metabolism/*prevention & control
MH  - Ultraviolet Rays
MH  - Ultraviolet Therapy
MH  - Vitamin B Complex/*pharmacology
PMC - PMC6362121
COIS- The authors declare no competing interests.
EDAT- 2019/02/06 06:00
MHDA- 2020/08/26 06:00
PMCR- 2019/02/04
CRDT- 2019/02/06 06:00
PHST- 2018/04/11 00:00 [received]
PHST- 2018/12/13 00:00 [accepted]
PHST- 2019/02/06 06:00 [entrez]
PHST- 2019/02/06 06:00 [pubmed]
PHST- 2020/08/26 06:00 [medline]
PHST- 2019/02/04 00:00 [pmc-release]
AID - 10.1038/s41598-018-38137-7 [pii]
AID - 38137 [pii]
AID - 10.1038/s41598-018-38137-7 [doi]
PST - epublish
SO  - Sci Rep. 2019 Feb 4;9(1):1252. doi: 10.1038/s41598-018-38137-7.