PMID- 30719156
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1837-9664 (Print)
IS  - 1837-9664 (Electronic)
IS  - 1837-9664 (Linking)
VI  - 10
IP  - 3
DP  - 2019
TI  - Pretreatment albumin globulin ratio has a superior prognostic value in laryngeal 
      squamous cell carcinoma patients: a comparison study.
PG  - 594-601
LID - 10.7150/jca.28817 [doi]
AB  - Background: Many inflammation-based markers have been reported their prognostic 
      significance. Current study was designed to explore the prognostic value of 
      albumin/globulin ratio (AGR), along with other inflammation-based markers, 
      including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and 
      lymphocyte/monocyte ratio (LMR) in laryngeal squamous cell carcinoma (LSCC) 
      patients. Method: This study was a retrospective analysis of the data related to 
      232 newly diagnosed LSCC patients. The potential prognostic factors were 
      evaluated by univariate and multivariate survival analysis. The correlation 
      between AGR and other prognostic factors were analyzed, and the area under the 
      curve (AUC) were compared. Results: AGR, NLR, PLR and LMR were found to be 
      associated with several aggressive clinicopathological features and poor 
      prognosis. In multivariate analysis, AGR, NLR, PLR, LMR were independent 
      prognostic markers of the shorter OS. However, NLR, PLR, and LMR showed no 
      significance with the shorter DFS. AGR remained an independent prognostic marker 
      for the shorter DFS. Furthermore, AGR was a superior prognosis factor than NLR, 
      PLR, LMR in LSCC patients. Conclusion: AGR might be a promising marker to better 
      predicting prognosis of LSCC patients. Future studies are warranted to validate 
      our finding.
FAU - Zhou, Tao
AU  - Zhou T
AD  - Department of Thyroid and Neck Surgery, The Second Affiliated Hospital of 
      Nanchang University, Nanchang, Jiangxi, China.
FAU - Yu, Shi-Tong
AU  - Yu ST
AD  - Department of General Surgery, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong, China.
FAU - Chen, Wan-Zhi
AU  - Chen WZ
AD  - Department of Thyroid and Neck Surgery, The Second Affiliated Hospital of 
      Nanchang University, Nanchang, Jiangxi, China.
FAU - Xie, Rong
AU  - Xie R
AD  - Department of Thyroid and Neck Surgery, The Second Affiliated Hospital of 
      Nanchang University, Nanchang, Jiangxi, China.
FAU - Yu, Ji-Chun
AU  - Yu JC
AD  - Department of Thyroid and Neck Surgery, The Second Affiliated Hospital of 
      Nanchang University, Nanchang, Jiangxi, China.
LA  - eng
PT  - Journal Article
DEP - 20190101
PL  - Australia
TA  - J Cancer
JT  - Journal of Cancer
JID - 101535920
PMC - PMC6360422
OTO - NOTNLM
OT  - albumin/globulin ratio
OT  - inflammation-based markers
OT  - laryngeal squamous cell carcinoma
OT  - prognosis
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2019/02/06 06:00
MHDA- 2019/02/06 06:01
PMCR- 2019/01/01
CRDT- 2019/02/06 06:00
PHST- 2018/07/27 00:00 [received]
PHST- 2018/12/14 00:00 [accepted]
PHST- 2019/02/06 06:00 [entrez]
PHST- 2019/02/06 06:00 [pubmed]
PHST- 2019/02/06 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - jcav10p0594 [pii]
AID - 10.7150/jca.28817 [doi]
PST - epublish
SO  - J Cancer. 2019 Jan 1;10(3):594-601. doi: 10.7150/jca.28817. eCollection 2019.