PMID- 30719346
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2090-0724 (Print)
IS  - 2090-0732 (Electronic)
IS  - 2090-0724 (Linking)
VI  - 2019
DP  - 2019
TI  - CNDP1, NOS3, and MnSOD Polymorphisms as Risk Factors for Diabetic Nephropathy 
      among Type 2 Diabetic Patients in Malaysia.
PG  - 8736215
LID - 10.1155/2019/8736215 [doi]
LID - 8736215
AB  - Type 2 diabetes mellitus (T2DM) is associated with a high incidence of 
      nephropathy. The aim of this study was to investigate the association of a 
      genetic polymorphism of carnosinase (CNDP1-D18S880 and -rs2346061), endothelial 
      nitric oxide synthase (NOS3-rs1799983), and manganese superoxide dismutase 
      (MnSOD-rs4880) genes with the development of diabetic nephropathy among Malaysian 
      type 2 diabetic patients. A case-control association study was performed using 
      652 T2DM patients comprising 227 Malays (without nephropathy = 96 and nephropathy 
      = 131), 203 Chinese (without nephropathy = 95 and nephropathy = 108), and 222 
      Indians (without nephropathy = 136 and nephropathy = 86). DNA sequencing was 
      performed for the D18S880 of CNDP1, while the rest were tested using DNA Sequenom 
      MassARRAY to identify the polymorphisms. DNA was extracted from the secondary 
      blood samples taken from the T2DM patients. The alleles and genotypes were tested 
      using four genetic models, and the best mode of inheritance was chosen based on 
      the least p value. The rs2346061 of CNDP1 was significantly associated with 
      diabetic nephropathy among the Indians only with OR = 1.94 and 95% CI = 
      (1.76-3.20) and fitted best the multiplicative model, while D18S880 was 
      associated among all the three major races with the Malays having the strongest 
      association with OR = 2.46 and 95% CI = (1.48-4.10), Chinese with OR = 2.26 and 
      95% CI = (1.34-3.83), and Indians with OR = 1.77 and 95% CI = (1.18-2.65) in the 
      genotypic multiplicative model. The best mode of inheritance for both MnSOD and 
      NOS3 was the additive model. For MnSOD-rs4880, the Chinese had OR = 2.8 and 95% 
      CI = (0.53-14.94), Indians had OR = 2.4 and 95% CI = (0.69-2.84), and Malays had 
      OR = 2.16 and 95% CI = (0.54-8.65), while for NOS3-rs1799983, the Indians had the 
      highest risk with OR = 3.16 and 95% CI = (0.52-17.56), followed by the Chinese 
      with OR = 3.55 and 95% CI = (0.36-35.03) and the Malays with OR = 2.89 and 95% CI 
      = (0.29-28.32). The four oxidative stress-related polymorphisms have significant 
      effects on the development of nephropathy in type 2 diabetes patients. The genes 
      may, therefore, be considered as risk factors for Malaysian subjects who are 
      predisposed to T2DM nephropathy.
FAU - Yahya, Mohd Jokha
AU  - Yahya MJ
AUID- ORCID: 0000-0003-0391-8039
AD  - Department of Biomedical, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, Seri Kembangan, Malaysia.
FAU - Ismail, Patimah Binti
AU  - Ismail PB
AD  - Department of Human Development and Growth, Faculty of Medicine and Health 
      Sciences, Universiti Putra Malaysia, Seri Kembangan, Malaysia.
FAU - Nordin, Norshariza Binti
AU  - Nordin NB
AUID- ORCID: 0000-0003-1019-0496
AD  - Department of Biomedical, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, Seri Kembangan, Malaysia.
FAU - Akim, Abdah Binti Md
AU  - Akim ABM
AD  - Department of Biomedical, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, Seri Kembangan, Malaysia.
FAU - Binti Md Yusuf, Wan Shaariah
AU  - Binti Md Yusuf WS
AD  - Department of Medicine, Department of Medicine (Endocrinology & Nephrology), 
      Hospital Tuanku Ja'afar, Seremban, Malaysia.
FAU - Adam, Noor Lita Binti
AU  - Adam NLB
AD  - Department of Medicine, Department of Medicine (Endocrinology & Nephrology), 
      Hospital Tuanku Ja'afar, Seremban, Malaysia.
FAU - Zulkifli, Nurul Fasihah
AU  - Zulkifli NF
AD  - Department of Biomedical, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, Seri Kembangan, Malaysia.
LA  - eng
PT  - Journal Article
DEP - 20190103
PL  - United States
TA  - J Nutr Metab
JT  - Journal of nutrition and metabolism
JID - 101526296
PMC - PMC6335667
EDAT- 2019/02/06 06:00
MHDA- 2019/02/06 06:01
PMCR- 2019/01/03
CRDT- 2019/02/06 06:00
PHST- 2018/09/24 00:00 [received]
PHST- 2018/11/13 00:00 [revised]
PHST- 2018/11/26 00:00 [accepted]
PHST- 2019/02/06 06:00 [entrez]
PHST- 2019/02/06 06:00 [pubmed]
PHST- 2019/02/06 06:01 [medline]
PHST- 2019/01/03 00:00 [pmc-release]
AID - 10.1155/2019/8736215 [doi]
PST - epublish
SO  - J Nutr Metab. 2019 Jan 3;2019:8736215. doi: 10.1155/2019/8736215. eCollection 
      2019.