PMID- 30719810
OWN - NLM
STAT- MEDLINE
DCOM- 20190709
LR  - 20190709
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 69
IP  - 3
DP  - 2019 Mar
TI  - Anaplastic large cell lymphoma with TP63 rearrangement: A dismal prognosis.
PG  - 155-159
LID - 10.1111/pin.12758 [doi]
AB  - Anaplastic large cell lymphoma (ALCL) with TP63 rearrangement is a new entity and 
      has the most dismal prognosis in all types of ALCL. This might be due to the 
      resulting fusion protein having N-terminal truncated p63 with high oncogenic 
      ability. Since this N-terminal domain has the function of tumor suppressor 
      activity, the mechanism for high oncogenic capacity is thought to be the dominant 
      negative function. Here, we report two ALCL cases with TP63 rearrangement that 
      was each given too short a prognosis (Case 1 and 2: four and six months) in spite 
      of intensive treatment. Immunohistochemically, p63 was highly expressed, and a 
      sprit signal was detected using a TP63 break apart fluorescence in situ 
      hybridization (FISH) in each case. Additionally, a poor prognostic marker of 
      ALCL, all cytotoxic molecules (TIA-1, Granzyme B, and Perforin) were also 
      expressed in almost all ALCL cells. Taken together, we suggest that not only the 
      dominant negative function of N-truncated p63 but also the effect of cytotoxic 
      molecules may influence the dismal prognosis of ALCL with TP63 rearrangement.
CI  - (c) 2019 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.
FAU - Yamashita, Takahisa
AU  - Yamashita T
AD  - Department of Pathology, Saitama Medical Center, Saitama Medical University, 1981 
      Kamoda, Kawagoe-shi, Saitama, 3508550, Japan.
FAU - Higashi, Morihiro
AU  - Higashi M
AD  - Department of Pathology, Saitama Medical Center, Saitama Medical University, 1981 
      Kamoda, Kawagoe-shi, Saitama, 3508550, Japan.
FAU - Kawano, Ryutaro
AU  - Kawano R
AD  - Department of Pathology, Saitama Medical Center, Saitama Medical University, 1981 
      Kamoda, Kawagoe-shi, Saitama, 3508550, Japan.
FAU - Momose, Shuji
AU  - Momose S
AD  - Department of Pathology, Saitama Medical Center, Saitama Medical University, 1981 
      Kamoda, Kawagoe-shi, Saitama, 3508550, Japan.
FAU - Tokuhira, Michihide
AU  - Tokuhira M
AD  - Department of Hematology, Saitama Medical Center, Saitama Medical University, 
      1981 Kamoda, Kawagoe-shi, Saitama, 3508550, Japan.
FAU - Kizaki, Masahiro
AU  - Kizaki M
AD  - Department of Hematology, Saitama Medical Center, Saitama Medical University, 
      1981 Kamoda, Kawagoe-shi, Saitama, 3508550, Japan.
FAU - Tamaru, Jun-Ichi
AU  - Tamaru JI
AD  - Department of Pathology, Saitama Medical Center, Saitama Medical University, 1981 
      Kamoda, Kawagoe-shi, Saitama, 3508550, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20190205
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (T-Cell Intracellular Antigen-1)
RN  - 0 (TIA1 protein, human)
RN  - 0 (TP63 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 3.4.21.- (Granzymes)
SB  - IM
MH  - Aged
MH  - Female
MH  - Granzymes
MH  - Hodgkin Disease/diagnosis/*pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Lymphoma, Large-Cell, Anaplastic/diagnosis/*metabolism/*pathology
MH  - Male
MH  - Prognosis
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Receptor Protein-Tyrosine Kinases/metabolism
MH  - T-Cell Intracellular Antigen-1/metabolism
MH  - Transcription Factors/*metabolism
MH  - Tumor Suppressor Proteins/*metabolism
OTO - NOTNLM
OT  - Anaplastic large cell lymphoma (ALCL)
OT  - FISH
OT  - TP63
OT  - cytotoxic molecule
EDAT- 2019/02/06 06:00
MHDA- 2019/07/10 06:00
CRDT- 2019/02/06 06:00
PHST- 2018/05/17 00:00 [received]
PHST- 2018/12/02 00:00 [accepted]
PHST- 2019/02/06 06:00 [pubmed]
PHST- 2019/07/10 06:00 [medline]
PHST- 2019/02/06 06:00 [entrez]
AID - 10.1111/pin.12758 [doi]
PST - ppublish
SO  - Pathol Int. 2019 Mar;69(3):155-159. doi: 10.1111/pin.12758. Epub 2019 Feb 5.