PMID- 30721868
OWN - NLM
STAT- MEDLINE
DCOM- 20190403
LR  - 20190403
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 247
DP  - 2019 Apr
TI  - Toxic effects of boscalid in adult zebrafish (Danio rerio) on carbohydrate and 
      lipid metabolism.
PG  - 775-782
LID - S0269-7491(18)34233-7 [pii]
LID - 10.1016/j.envpol.2019.01.054 [doi]
AB  - Boscalid as one of the most widely used succinate dehydrogenase inhibitor (SDHI) 
      fungicides has been frequently detected in both freshwater and estuarine 
      environments. Its acute toxic effects on zebrafish and freshwater algae have been 
      reported in our previous studies. To further investigate its chronic toxic 
      effects to aquatic organisms, adult zebrafish were exposed for 28 days to a 
      series of environmentally relevant boscalid concentrations in this study. Growth 
      indicators and histopathology were determined in this study. Results indicated 
      that boscalid inhibited the growth of zebrafish and induced damage in the kidneys 
      and liver. Carbohydrate and lipid metabolism as the key pathways of energy 
      metabolism in growth of zebrafish were also investigated. Results showed boscalid 
      caused an increase in the activity of hexokinase (HK), the content of glycogen, 
      glucose-6-phosphatase (G6Pase), and insulin (INS) in liver and a decrease in 
      blood glucose content and succinate dehydrogenase (SDH) activity. Boscalid 
      reduced the total content of triacylglyceride (TG) and cholesterol (TC) and the 
      activity of fatty acid synthase (FAS) and acetyl coenzyme A carboxylase (ACC) in 
      the liver. Correspondingly, expression of the genes related to carbohydrate and 
      lipid metabolism in liver and intestine was affected by boscalid, especially in 
      the significant upregulation of G6Pase and pparalpha and downregulation of SGLT-1 and 
      AMY. Results suggested that boscalid could affect carbohydrate metabolism of 
      adult zebrafish via regulation of gluconeogenesis and glycolysis at 0.1 mg/L. 
      Moreover, boscalid might induce an increase in beta-oxidation and a decrease in 
      lipid synthesis at 0.01 mg/L. In conclusion, our study identified that 
      carbohydrate and lipid metabolism are the possible biological pathways that 
      mediate boscalid-induced developmental effects.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Qian, Le
AU  - Qian L
AD  - College of Sciences, China Agricultural University, Beijing, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - College of Sciences, China Agricultural University, Beijing, China.
FAU - Chen, Xiangguang
AU  - Chen X
AD  - College of Sciences, China Agricultural University, Beijing, China.
FAU - Qi, Suzhen
AU  - Qi S
AD  - Risk Assessment Laboratory for Bee Products Quality and Safety of Ministry of 
      Agriculture, Institute of Agricultural Research, Chinese Academy of Agricultural 
      Sciences, Beijing, 100093, China.
FAU - Wu, Peizhuo
AU  - Wu P
AD  - College of Sciences, China Agricultural University, Beijing, China.
FAU - Wang, Chen
AU  - Wang C
AD  - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese 
      Research Academy of Environmental Sciences, Beijing, China.
FAU - Wang, Chengju
AU  - Wang C
AD  - College of Sciences, China Agricultural University, Beijing, China. Electronic 
      address: wangchengju@cau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190118
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Fungicides, Industrial)
RN  - 25X51I8RD4 (Niacinamide)
RN  - 32MS8ZRD1V (2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide)
RN  - 9005-79-2 (Glycogen)
SB  - IM
EIN - Environ Pollut. 2020 Feb;257:113746. PMID: 31962546
MH  - Animals
MH  - Aquatic Organisms/metabolism
MH  - Biphenyl Compounds/*toxicity
MH  - Carbohydrate Metabolism/*drug effects
MH  - Fungicides, Industrial/metabolism/*toxicity
MH  - Glycogen/metabolism
MH  - Lipid Metabolism/*drug effects
MH  - Liver/metabolism
MH  - Niacinamide/*analogs & derivatives/toxicity
MH  - Oxidation-Reduction
MH  - Toxicity Tests
MH  - Zebrafish/metabolism/*physiology
OTO - NOTNLM
OT  - Boscalid
OT  - Carbohydrate metabolism
OT  - Lipid metabolism
OT  - Zebrafish
OT  - beta-Oxidation
EDAT- 2019/02/06 06:00
MHDA- 2019/04/04 06:00
CRDT- 2019/02/06 06:00
PHST- 2018/09/17 00:00 [received]
PHST- 2019/01/08 00:00 [revised]
PHST- 2019/01/15 00:00 [accepted]
PHST- 2019/02/06 06:00 [pubmed]
PHST- 2019/04/04 06:00 [medline]
PHST- 2019/02/06 06:00 [entrez]
AID - S0269-7491(18)34233-7 [pii]
AID - 10.1016/j.envpol.2019.01.054 [doi]
PST - ppublish
SO  - Environ Pollut. 2019 Apr;247:775-782. doi: 10.1016/j.envpol.2019.01.054. Epub 
      2019 Jan 18.