PMID- 30721990
OWN - NLM
STAT- MEDLINE
DCOM- 20200224
LR  - 20200224
IS  - 1460-2377 (Electronic)
IS  - 0953-8178 (Linking)
VI  - 31
IP  - 5
DP  - 2019 Apr 26
TI  - FcgammaRIIIA-mediated activation of NK cells by IgG heavy chain complexed with MHC 
      class II molecules.
PG  - 303-314
LID - 10.1093/intimm/dxz010 [doi]
AB  - Natural killer (NK) cells are a major FcgammaRIIIA-expressing lymphocyte population 
      that mediate antibody-dependent cellular cytotoxicity. Although NK cells are 
      critical for immunity against viruses and tumors, they are also activated in the 
      joints of patients with rheumatoid arthritis (RA) and may be involved in disease 
      progression. We previously found that human leukocyte antigen (HLA) class II 
      molecules transport misfolded cellular proteins, such as IgG heavy chain (IgGH), 
      to the cell surface via association with their peptide-binding grooves. 
      Furthermore, we found that IgGHs bound to HLA class II molecules encoded by RA 
      susceptibility alleles are specific targets for rheumatoid factor, an 
      auto-antibody involved in RA. Here, we report that IgGHs bound to HLA class II 
      molecules preferentially stimulate FcgammaRIIIA-expressing but not FcgammaRI-expressing 
      cells. A significant correlation was observed between the reactivity of 
      FcgammaRIIIA-expressing cells to IgGH complexed with a specific HLA-DR allele and the 
      odds ratio for HLA-DR allele's association with RA. Moreover, primary human NK 
      cells expressing FcgammaRIIIA demonstrated IFN-gamma production and cytotoxicity against 
      cells expressing IgGH complexed with HLA class II molecules. Our findings suggest 
      that IgGH complexed with HLA class II molecules are involved in the activation of 
      FcgammaRIIIA-expressing NK cells observed within arthritic joints.
CI  - (c) The Japanese Society for Immunology. 2019. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Shimizu, Yuta
AU  - Shimizu Y
AD  - Department of Immunochemistry, Research Institute for Microbial Diseases.
AD  - Laboratory of Immunochemistry, WPI Immunology Frontier Research Center.
FAU - Kohyama, Masako
AU  - Kohyama M
AD  - Department of Immunochemistry, Research Institute for Microbial Diseases.
AD  - Laboratory of Immunochemistry, WPI Immunology Frontier Research Center.
FAU - Yorifuji, Hideki
AU  - Yorifuji H
AD  - Department of Immunochemistry, Research Institute for Microbial Diseases.
AD  - Laboratory of Immunochemistry, WPI Immunology Frontier Research Center.
AD  - Department of Respiratory Medicine and Clinical Immunology, Graduate School of 
      Medicine.
FAU - Jin, Hui
AU  - Jin H
AD  - Laboratory of Immunochemistry, WPI Immunology Frontier Research Center.
FAU - Arase, Noriko
AU  - Arase N
AD  - Department of Immunochemistry, Research Institute for Microbial Diseases.
AD  - Department of Dermatology, Graduate School of Medicine, Osaka University, Suita, 
      Osaka 565-0871, Japan.
FAU - Suenaga, Tadahiro
AU  - Suenaga T
AD  - Department of Immunochemistry, Research Institute for Microbial Diseases.
AD  - Laboratory of Immunochemistry, WPI Immunology Frontier Research Center.
FAU - Arase, Hisashi
AU  - Arase H
AD  - Department of Immunochemistry, Research Institute for Microbial Diseases.
AD  - Laboratory of Immunochemistry, WPI Immunology Frontier Research Center.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (FCGR3A protein, human)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - HEK293 Cells
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Humans
MH  - Immunoglobulin G/*immunology
MH  - Immunoglobulin Heavy Chains/*immunology
MH  - Killer Cells, Natural/*immunology
MH  - Receptors, IgG/*immunology
OTO - NOTNLM
OT  - FcgammaR
OT  - HLA class II
OT  - autoimmune disease
OT  - misfolded protein
OT  - natural killer cells
EDAT- 2019/02/06 06:00
MHDA- 2020/02/25 06:00
CRDT- 2019/02/06 06:00
PHST- 2018/12/08 00:00 [received]
PHST- 2019/01/31 00:00 [accepted]
PHST- 2019/02/06 06:00 [pubmed]
PHST- 2020/02/25 06:00 [medline]
PHST- 2019/02/06 06:00 [entrez]
AID - 5307159 [pii]
AID - 10.1093/intimm/dxz010 [doi]
PST - ppublish
SO  - Int Immunol. 2019 Apr 26;31(5):303-314. doi: 10.1093/intimm/dxz010.