PMID- 30723587
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210112
IS  - 2162-4011 (Print)
IS  - 2162-402X (Electronic)
IS  - 2162-4011 (Linking)
VI  - 8
IP  - 3
DP  - 2019
TI  - Nuclear receptor ligands induce TREM-1 expression on dendritic cells: analysis of 
      their role in tumors.
PG  - 1554967
LID - 10.1080/2162402X.2018.1554967 [doi]
LID - 1554967
AB  - Dendritic cells (DCs) initiate adaptive immune responses after their migration to 
      secondary lymphoid organs. The LXR ligands/oxysterols and the RXR ligand 9-cis 
      Retinoic Acid (9-cis RA) were shown to dampen DC migration to lymphoid organs 
      through the inhibition of CCR7 expression. We performed transcriptomics of DCs 
      undergoing maturation in the presence of the LXR ligand 22R-Hydroxycholesterol 
      (22R-HC). The analysis highlighted more than 1500 genes modulated by 22R-HC 
      treatment, including the triggering receptor expressed on myeloid cells (TREM)-1, 
      which was found markedly up-regulated. We tested the effect of other nuclear 
      receptor ligands (NRL) and we reported the induction of TREM-1 following RXR, RAR 
      and VDR activation. From a functional point of view, triggering of TREM-1 induced 
      by retinoids increased TNFalpha and IL-1beta release, suggesting an active role of 
      NRL-activated TREM-1(+) DCs in inflammation-driven diseases, including cancer. 
      Consistently with this hypothesis we detected DCs expressing TREM-1 in pleural 
      effusions and ascites of cancer patients, an observation validated by the 
      induction of TREM-1, LXR and RAR target genes when monocyte-DCs were activated in 
      the presence of tumor-conditioned fluids. Finally, we observed a better control 
      of LLC tumor growth in Trem-1(-/-) bone marrow chimera mice as compared to wild 
      type chimera mice. Future studies will be necessary to shed light on the 
      mechanism of TREM-1 induction by distinct NRL, and to characterize the role of 
      TREM-1(+) DCs in tumor growth.
FAU - Fontana, Raffaella
AU  - Fontana R
AD  - Immuno-Biotherapy of Melanoma and Solid Tumors Unit, Division of Experimental 
      Oncology, IRCCS Scientific Institute San Raffaele, Milan, Italy.
FAU - Raccosta, Laura
AU  - Raccosta L
AUID- ORCID: 0000-0002-1625-9573
AD  - Immuno-Biotherapy of Melanoma and Solid Tumors Unit, Division of Experimental 
      Oncology, IRCCS Scientific Institute San Raffaele, Milan, Italy.
FAU - Rovati, Lucrezia
AU  - Rovati L
AD  - Immuno-Biotherapy of Melanoma and Solid Tumors Unit, Division of Experimental 
      Oncology, IRCCS Scientific Institute San Raffaele, Milan, Italy.
FAU - Steffensen, Knut R
AU  - Steffensen KR
AD  - Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden.
FAU - Paniccia, Aida
AU  - Paniccia A
AD  - Immuno-Biotherapy of Melanoma and Solid Tumors Unit, Division of Experimental 
      Oncology, IRCCS Scientific Institute San Raffaele, Milan, Italy.
FAU - Jakobsson, Tomas
AU  - Jakobsson T
AD  - Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden.
FAU - Melloni, Giulio
AU  - Melloni G
AD  - Thoracic Surgery Unit, IRCCS Scientific Institute San Raffaele, Milan, Italy.
FAU - Bandiera, Alessandro
AU  - Bandiera A
AD  - Thoracic Surgery Unit, IRCCS Scientific Institute San Raffaele, Milan, Italy.
FAU - Mangili, Giorgia
AU  - Mangili G
AD  - Gynecologic Unit, IRCCS Scientific Institute San Raffaele, Milan, Italy.
FAU - Bergamini, Alice
AU  - Bergamini A
AD  - Gynecologic Unit, IRCCS Scientific Institute San Raffaele, Milan, Italy.
FAU - Maggioni, Daniela
AU  - Maggioni D
AD  - Immuno-Biotherapy of Melanoma and Solid Tumors Unit, Division of Experimental 
      Oncology, IRCCS Scientific Institute San Raffaele, Milan, Italy.
FAU - Doglioni, Claudio
AU  - Doglioni C
AD  - Department of Pathology, IRCCS Scientific Institute San Raffaele, Milan, Italy.
AD  - Department of Pathology, Universita Vita-Salute San Raffaele, Milan, Italy.
FAU - Crocchiolo, Roberto
AU  - Crocchiolo R
AD  - Hematology Unit, ASST Bergamo Ovest, Treviglio, Italy.
FAU - Cella, Marina
AU  - Cella M
AD  - Department of Pathology and Immunology, Washington University School of Medicine, 
      St Louis, MO, USA.
FAU - Mattioli, Michela
AU  - Mattioli M
AD  - Department of Medical Biotechnology and Translational Medicine (BIOMETRA), 
      University of Milan, Segrate, Italy.
FAU - Battaglia, Cristina
AU  - Battaglia C
AUID- ORCID: 0000-0003-3025-9657
AD  - Department of Medical Biotechnology and Translational Medicine (BIOMETRA), 
      University of Milan, Segrate, Italy.
FAU - Colonna, Marco
AU  - Colonna M
AD  - Department of Pathology and Immunology, Washington University School of Medicine, 
      St Louis, MO, USA.
FAU - Russo, Vincenzo
AU  - Russo V
AD  - Immuno-Biotherapy of Melanoma and Solid Tumors Unit, Division of Experimental 
      Oncology, IRCCS Scientific Institute San Raffaele, Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181213
PL  - United States
TA  - Oncoimmunology
JT  - Oncoimmunology
JID - 101570526
PMC - PMC6350683
OTO - NOTNLM
OT  - LXR nuclear receptors
OT  - RAR/RXR nuclear receptors
OT  - TREM-1
OT  - dendritic cells
OT  - lung cancer
OT  - ovarian cancer
EDAT- 2019/02/07 06:00
MHDA- 2019/02/07 06:01
PMCR- 2019/12/13
CRDT- 2019/02/07 06:00
PHST- 2018/05/25 00:00 [received]
PHST- 2018/11/02 00:00 [revised]
PHST- 2018/11/26 00:00 [accepted]
PHST- 2019/02/07 06:00 [entrez]
PHST- 2019/02/07 06:00 [pubmed]
PHST- 2019/02/07 06:01 [medline]
PHST- 2019/12/13 00:00 [pmc-release]
AID - 1554967 [pii]
AID - 10.1080/2162402X.2018.1554967 [doi]
PST - epublish
SO  - Oncoimmunology. 2018 Dec 13;8(3):1554967. doi: 10.1080/2162402X.2018.1554967. 
      eCollection 2019.