PMID- 30725267
OWN - NLM
STAT- MEDLINE
DCOM- 20200120
LR  - 20200120
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 191
IP  - 2
DP  - 2019 Oct
TI  - Selenium Levels in Community Dwellers with Type 2 Diabetes Mellitus.
PG  - 354-362
LID - 10.1007/s12011-019-1645-6 [doi]
AB  - Selenium (Se) is an essential micronutrient required by the human body and exerts 
      biological functions through selenoproteins. The relationship between Se and 
      diabetes remains ambiguous. This study aimed at, through measurements of serum 
      selenoprotein P (SelP), glutathione peroxidase (GPx3), and Se content in serum 
      and hair, evaluating Se levels in community dwellers with type 2 diabetes 
      mellitus (T2DM). A total of 336 subjects, including 176 T2DM patients 
      (65.5 +/- 8.7 years old) and 160 healthy residents (63.7 +/- 9.8 years old, as 
      controls), were recruited in this cross-sectional community-based study performed 
      in Suzhou. Samples of fasting venous blood and hair were collected for 
      measurements of Se levels, glycometabolism, and biochemistry parameters. We found 
      that the serum Se level and SelP concentration in T2DM patients were 
      substantially higher than those in healthy residents (p < 0.05). There was no 
      significant difference in GPx3 activity and hair Se level between the two groups 
      of subjects (p > 0.05). Serum Se was positively correlated with both GPx3 and 
      hair Se in T2DM patients (r = 0.167 and 0.164, respectively, p < 0.05) and 
      negatively correlated with SelP in healthy controls (r = - 0.293, p < 0.05). In 
      conclusion, this study showed significantly higher levels of serum Se and SelP in 
      community dwellers with T2DM than in matched healthy residents.
FAU - Zhang, Qianqian
AU  - Zhang Q
AD  - School of Nursing, Medical College, Soochow University, No.1 Shizi Street, 
      Suzhou, 215006, China.
FAU - Li, Wenxia
AU  - Li W
AD  - School of Nursing, Medical College, Soochow University, No.1 Shizi Street, 
      Suzhou, 215006, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Research Center, Soochow Setek Biotechnology Co., Ltd, Suzhou, China.
FAU - Hu, Biyue
AU  - Hu B
AD  - School of Nursing, Medical College, Soochow University, No.1 Shizi Street, 
      Suzhou, 215006, China.
FAU - Yun, Hang
AU  - Yun H
AD  - School of Nursing, Medical College, Soochow University, No.1 Shizi Street, 
      Suzhou, 215006, China.
FAU - Guo, Renmei
AU  - Guo R
AD  - Research Center, Soochow Setek Biotechnology Co., Ltd, Suzhou, China.
FAU - Wang, Li
AU  - Wang L
AUID- ORCID: 0000-0003-2669-826X
AD  - School of Nursing, Medical College, Soochow University, No.1 Shizi Street, 
      Suzhou, 215006, China. li-wang-1@suda.edu.cn.
LA  - eng
GR  - Q412700114/the Startup Foundation for Talents of Soochow University/
PT  - Journal Article
DEP - 20190206
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (Selenoprotein P)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glutathione Peroxidase/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Selenium/analysis/*blood
MH  - Selenoprotein P/*blood
OTO - NOTNLM
OT  - Diabetes mellitus, type 2
OT  - Glutathione peroxidase
OT  - Selenium
OT  - Selenoprotein P
EDAT- 2019/02/07 06:00
MHDA- 2020/01/21 06:00
CRDT- 2019/02/07 06:00
PHST- 2018/09/19 00:00 [received]
PHST- 2019/01/17 00:00 [accepted]
PHST- 2019/02/07 06:00 [pubmed]
PHST- 2020/01/21 06:00 [medline]
PHST- 2019/02/07 06:00 [entrez]
AID - 10.1007/s12011-019-1645-6 [pii]
AID - 10.1007/s12011-019-1645-6 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2019 Oct;191(2):354-362. doi: 10.1007/s12011-019-1645-6. 
      Epub 2019 Feb 6.