PMID- 30728748
OWN - NLM
STAT- MEDLINE
DCOM- 20190808
LR  - 20220331
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2019
DP  - 2019
TI  - Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients 
      with Chronic Heart Failure.
PG  - 1575410
LID - 10.1155/2019/1575410 [doi]
LID - 1575410
AB  - BACKGROUND: Interleukin-11 (IL-11) is an important inflammatory cytokine and has 
      been demonstrated to participate in cardiovascular diseases. However, there have 
      been no studies about the role of IL-11 in heart failure (HF). The present study 
      is aimed at investigating whether IL-11 levels are associated with the cardiac 
      prognosis in patients with HF. METHODS: The plasma concentrations of IL-11 were 
      measured in 240 patients with chronic HF (CHF) and 80 control subjects without 
      signs of significant heart disease. In addition, we prospectively followed these 
      CHF patients to endpoints of cardiac events. RESULTS: Compared with the control 
      group, the plasma IL-11 concentrations were significantly increased in the CHF 
      patients and gradually increased in the New York Heart Association (NYHA) 
      functional class II group, the NYHA functional class III group, and the NYHA 
      functional class IV group. The receiver operating characteristic (ROC) curve 
      revealed that the predictive role of IL-11 in HF is not as good as N-terminal 
      B-type natriuretic peptide (BNP), although IL-11 has a certain value in 
      predicting cardiac events. In addition, the CHF patients were divided into 3 
      groups according to the plasma IL-11 concentration category (low, T1; middle, T2; 
      and high, T3). The multivariate Cox hazard analysis showed that the high plasma 
      IL-11 concentrations were independently associated with the presence of cardiac 
      events after adjustment for confounding factors. Furthermore, the CHF patients 
      were divided into two groups based on the median plasma IL-11 concentrations. The 
      Kaplan-Meier analysis revealed that the patients with high IL-11 concentrations 
      had a higher risk of cardiac events compared with those with low IL-11 
      concentrations. CONCLUSIONS: Higher plasma IL-11 levels significantly increase 
      the presence of cardiac events and suggest a poor outcome; although the 
      diagnostic value of IL-11 in CHF is not as good as BNP, there is a certain value 
      in predicting cardiac events in CHF.
FAU - Ye, Jing
AU  - Ye J
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular 
      Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 
      430060, China.
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Wang, Zhen
AU  - Wang Z
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular 
      Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 
      430060, China.
FAU - Ye, Di
AU  - Ye D
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular 
      Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 
      430060, China.
FAU - Wang, Yuan
AU  - Wang Y
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular 
      Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 
      430060, China.
FAU - Wang, Menglong
AU  - Wang M
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular 
      Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 
      430060, China.
FAU - Ji, Qingwei
AU  - Ji Q
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Huang, Ying
AU  - Huang Y
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Liu, Ling
AU  - Liu L
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Shi, Ying
AU  - Shi Y
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Shi, Lei
AU  - Shi L
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Zeng, Tao
AU  - Zeng T
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Xu, Yao
AU  - Xu Y
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular 
      Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 
      430060, China.
FAU - Liu, Jianfang
AU  - Liu J
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular 
      Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 
      430060, China.
FAU - Jiang, Huimin
AU  - Jiang H
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular 
      Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 
      430060, China.
FAU - Lin, Yingzhong
AU  - Lin Y
AUID- ORCID: 0000-0003-4424-0340
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular 
      Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 
      430060, China.
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Wan, Jun
AU  - Wan J
AUID- ORCID: 0000-0003-4865-783X
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular 
      Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 
      430060, China.
LA  - eng
PT  - Journal Article
DEP - 20190108
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Cytokines)
RN  - 0 (IL11 protein, human)
RN  - 0 (Interleukin-11)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
MH  - Adult
MH  - Aged
MH  - Cardiovascular Diseases/blood/complications
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Cytokines/metabolism
MH  - Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*blood/complications
MH  - Humans
MH  - Inflammation
MH  - Interleukin-11/*blood
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Patient Discharge
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - ROC Curve
MH  - Ventricular Function, Left
PMC - PMC6341241
EDAT- 2019/02/08 06:00
MHDA- 2019/08/09 06:00
PMCR- 2019/01/08
CRDT- 2019/02/08 06:00
PHST- 2018/07/28 00:00 [received]
PHST- 2018/11/01 00:00 [revised]
PHST- 2018/11/13 00:00 [accepted]
PHST- 2019/02/08 06:00 [entrez]
PHST- 2019/02/08 06:00 [pubmed]
PHST- 2019/08/09 06:00 [medline]
PHST- 2019/01/08 00:00 [pmc-release]
AID - 10.1155/2019/1575410 [doi]
PST - epublish
SO  - Mediators Inflamm. 2019 Jan 8;2019:1575410. doi: 10.1155/2019/1575410. 
      eCollection 2019.