PMID- 30732132
OWN - NLM
STAT- MEDLINE
DCOM- 20190226
LR  - 20221207
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 6
DP  - 2019 Feb
TI  - Glutathione-S-transferases M1/T1 gene polymorphisms and male infertility risk in 
      Chinese populations: A meta-analysis.
PG  - e14166
LID - 10.1097/MD.0000000000014166 [doi]
LID - e14166
AB  - BACKGROUND: A meta-analysis was applied to evaluate the associations between the 
      glutathione-S-transferases (GSTs) M1/T1 gene polymorphisms and male infertility 
      in Chinese populations. METHODS: A comprehensive search for articles was 
      conducted from PubMed, Web of Science, Embase, China biology medical literature 
      database (CBM), China National Knowledge Infrastructure (CNKI), VIP, and Chinese 
      literature database(Wang fang) up to April 30, 2018. All of the statistical 
      analyses were performed using Review Manager 5.3 and Stata 14.0. RESULTS: Ten 
      studies on GSTM1 gene polymorphism involving 3302 cases and 1959 controls, and 
      ten studies on GSTT1 gene polymorphism involving 3048 cases and 1861 controls 
      were included in this meta-analysis. Overall, the null genotype of GSTM1/GSTT1 
      was significantly related to male infertility risk in Chinese populations (GSTM1, 
      OR = 1.35, 95% CI: 1.02-1.78; GSTT1, OR = 1.40, 95% CI: 1.15-1.70). In subgroup 
      analyses stratified by infertility type, significant association was observed 
      between GSTT1 null genotype and male infertility in both nonobstructive 
      azoospermia (NOA) and oligoasthenozoospermia (OAT). However, the GSTM1 null 
      genotype was associated with OAT, but not NOA in Chinese populations. The 
      sensitivity analysis confirmed the reliability and stability of the 
      meta-analysis. CONCLUSION: Our meta-analysis supports that the GSTM1/GSTT1 null 
      genotype might contribute to individual susceptibility to male infertility in 
      Chinese populations.
FAU - Hu, Chun-Yan
AU  - Hu CY
AD  - Department of Urology, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong.
FAU - Lu, Dong-Liang
AU  - Lu DL
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Wu, Tao
AU  - Wu T
AD  - Department of Urology, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong.
FAU - Cheng, Shu-Lin
AU  - Cheng SL
AD  - Department of Urology, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong.
FAU - Wu, Tian-Tian
AU  - Wu TT
AD  - Department of Urology, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong.
FAU - Wang, Shu
AU  - Wang S
AD  - Department of Urology, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong.
FAU - Zhang, Tao
AU  - Zhang T
AD  - Department of Urology, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - EC 2.5.1.- (glutathione S-transferase T1)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 2.5.1.18 (glutathione S-transferase M1)
RN  - Azoospermia, Nonobstructive
SB  - IM
MH  - Asian People/genetics
MH  - Azoospermia/genetics
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Glutathione Transferase/*genetics
MH  - Humans
MH  - Infertility, Male/ethnology/*genetics
MH  - Male
MH  - Odds Ratio
MH  - Oligospermia/genetics
MH  - Polymorphism, Genetic
MH  - Reproducibility of Results
PMC - PMC6380701
COIS- Conflict of interest: The authors have no conflicts of interest to disclose.
EDAT- 2019/02/09 06:00
MHDA- 2019/02/27 06:00
PMCR- 2019/02/08
CRDT- 2019/02/09 06:00
PHST- 2019/02/09 06:00 [entrez]
PHST- 2019/02/09 06:00 [pubmed]
PHST- 2019/02/27 06:00 [medline]
PHST- 2019/02/08 00:00 [pmc-release]
AID - 00005792-201902080-00013 [pii]
AID - MD-D-18-06677 [pii]
AID - 10.1097/MD.0000000000014166 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Feb;98(6):e14166. doi: 10.1097/MD.0000000000014166.