PMID- 30733169
OWN - NLM
STAT- MEDLINE
DCOM- 20200803
LR  - 20200803
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 208
DP  - 2019 Jun
TI  - An integrated neurocognitive and social-cognitive treatment for youth at clinical 
      high risk for psychosis: Cognition for Learning and for Understanding Everyday 
      Social Situations (CLUES).
PG  - 55-59
LID - S0920-9964(19)30033-7 [pii]
LID - 10.1016/j.schres.2019.01.029 [doi]
AB  - BACKGROUND: Cognitive deficits, a core feature contributing to disability in 
      schizophrenia, are present in milder form in individuals at clinical high risk 
      (CHR) for psychosis. This study investigated the feasibility of Cognition for 
      Learning and Understanding Everyday Social Situations (CLUES), an integrated 
      neurocognitive and social cognitive treatment for youth at CHR. METHOD: This was 
      an open, pilot feasibility trial. Seventeen individuals meeting CHR criteria were 
      assessed prior to and following participation in CLUES for changes in symptoms, 
      social and role functioning, and cognition. Participant attitudes towards CLUES 
      were also examined. RESULTS: Participants significantly improved in social 
      functioning [t(16) = -4.20, p = .001, d = 1.02], and trended for improvement in 
      reaction time [t(15) = 2.09, p = .054, d = 0.52] from baseline to end of 
      treatment. No other measures significantly changed. No participants transitioned 
      to full psychosis during the treatment and follow up period. Participants 
      reported they generally liked CLUES and found it helpful. CONCLUSION: While 
      limited by the small sample size and the open label design, our preliminary 
      results indicate that CLUES is feasible and shows promise in improving social 
      functioning. However, further investigation is warranted in order to determine 
      its efficacy. Future directions should include conducting a randomized controlled 
      trial in order to compare the efficacy of CLUES to another intervention.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Friedman-Yakoobian, M
AU  - Friedman-Yakoobian M
AD  - Public Psychiatry Division of Department of Psychiatry, Harvard Medical School at 
      Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, United 
      States of America. Electronic address: mfriedm3@bidmc.harvard.edu.
FAU - Parrish, E M
AU  - Parrish EM
AD  - Public Psychiatry Division of Department of Psychiatry, Harvard Medical School at 
      Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, United 
      States of America.
FAU - Thomas, A
AU  - Thomas A
AD  - University of Alabama Health System, United States of America.
FAU - Lesser, R
AU  - Lesser R
AD  - Cedars Sinai Medical Center, United States of America.
FAU - Gnong-Granato, A
AU  - Gnong-Granato A
AD  - The Plymouth Center for Behavioral Health, United States of America.
FAU - Eack, S
AU  - Eack S
AD  - University of Pittsburgh School of Social Work and Department of Psychiatry, 
      United States of America.
FAU - Keshavan, M S
AU  - Keshavan MS
AD  - Public Psychiatry Division of Department of Psychiatry, Harvard Medical School at 
      Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, United 
      States of America.
LA  - eng
GR  - R34 MH105596/MH/NIMH NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190205
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cognitive Dysfunction/etiology/*rehabilitation
MH  - Cognitive Remediation/*methods
MH  - Comprehension/physiology
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Learning/physiology
MH  - Male
MH  - Pilot Projects
MH  - Psychotic Disorders/complications/*rehabilitation
MH  - Risk
MH  - *Social Perception
MH  - *Social Skills
MH  - Young Adult
PMC - PMC6544485
MID - NIHMS1520767
OTO - NOTNLM
OT  - Attenuated psychosis
OT  - Clinical high risk for psychosis
OT  - Cognitive remediation, cognitive enhancement
OT  - Prevention
OT  - Treatment
COIS- Conflict of interest Statement There are no known conflicts of interest 
      associated with this publication and there has been no significant financial 
      support for this work that could have influenced its outcome.
EDAT- 2019/02/09 06:00
MHDA- 2020/08/04 06:00
PMCR- 2020/06/01
CRDT- 2019/02/09 06:00
PHST- 2018/10/24 00:00 [received]
PHST- 2019/01/18 00:00 [revised]
PHST- 2019/01/21 00:00 [accepted]
PHST- 2019/02/09 06:00 [pubmed]
PHST- 2020/08/04 06:00 [medline]
PHST- 2019/02/09 06:00 [entrez]
PHST- 2020/06/01 00:00 [pmc-release]
AID - S0920-9964(19)30033-7 [pii]
AID - 10.1016/j.schres.2019.01.029 [doi]
PST - ppublish
SO  - Schizophr Res. 2019 Jun;208:55-59. doi: 10.1016/j.schres.2019.01.029. Epub 2019 
      Feb 5.