PMID- 30733966
OWN - NLM
STAT- MEDLINE
DCOM- 20190527
LR  - 20220408
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2019
DP  - 2019
TI  - Electroacupuncture for Women with Chronic Severe Functional Constipation: 
      Subgroup Analysis of a Randomized Controlled Trial.
PG  - 7491281
LID - 10.1155/2019/7491281 [doi]
LID - 7491281
AB  - BACKGROUND: Acupuncture has been found to be effective for treating chronic 
      constipation. OBJECTIVE: The objective of this exploratory study was to evaluate 
      the efficacy of electroacupuncture (EA) in the subgroup of women with chronic 
      severe functional constipation. METHODS: This is a subgroup analysis of the 
      multicenter, randomized, sham-acupuncture (SA) controlled trial. The efficacy of 
      822 (76%) female patients of the 1075 randomized patients with chronic severe 
      functional constipation was evaluated. Patients were randomly assigned to receive 
      28 sessions of EA or SA over 8 weeks with 12 weeks' follow-up. This study focused 
      on sustained complete spontaneous bowel movements (CSBMs) responders over the 
      8-week treatment. RESULTS: The primary outcome which was percentage of the 
      sustained CSBMs responders for the subset of women with severe constipation was 
      significantly higher in the EA group (24.3%) than in the SA group (8.1%) with 
      difference of 13.1% (95%CI, 6.5% to 19.7%; P<0.001). As for the secondary 
      outcomes, responders for >/=9 of 12 weeks of follow-up were higher in the EA group 
      than in the SA group. Additionally, EA had significantly better improvement in 
      mean weekly CSBMs, mean weekly spontaneous bowel movements (SBMs), and mean score 
      changes of stool consistency and straining as well as quality of life of 
      patients. The incidence of adverse events (AEs) related to acupuncture was rare 
      and no statistical significance was found between two groups. CONCLUSION: EA 
      improved the spontaneity and the completeness of the bowel movement of women with 
      severe functional constipation during 8-week treatment and the effect sustained 
      for 12 weeks after stopping treatment.
FAU - Zhou, Jing
AU  - Zhou J
AD  - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
AD  - China Academy of Chinese Medical Sciences, Beijing, China.
FAU - Liu, Yan
AU  - Liu Y
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese 
      Medical Sciences, Beijing, China.
FAU - Zhou, Kehua
AU  - Zhou K
AD  - Catholic Health System Internal Medicine Training Program, University at Buffalo, 
      Buffalo, NY, USA.
FAU - Liu, Baoyan
AU  - Liu B
AUID- ORCID: 0000-0002-3281-3669
AD  - China Academy of Chinese Medical Sciences, Beijing, China.
FAU - Su, Tongsheng
AU  - Su T
AD  - Shaanxi Province Hospital of Traditional Chinese Medicine, Xi'an, China.
FAU - Wang, Weiming
AU  - Wang W
AUID- ORCID: 0000-0002-8403-2899
AD  - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
FAU - Liu, Zhishun
AU  - Liu Z
AUID- ORCID: 0000-0001-7570-8917
AD  - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20190113
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - Constipation/*physiopathology/*therapy
MH  - *Electroacupuncture/adverse effects
MH  - Female
MH  - Humans
MH  - Intention to Treat Analysis
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
PMC - PMC6348848
EDAT- 2019/02/09 06:00
MHDA- 2019/05/28 06:00
PMCR- 2019/01/13
CRDT- 2019/02/09 06:00
PHST- 2018/08/18 00:00 [received]
PHST- 2018/12/16 00:00 [accepted]
PHST- 2019/02/09 06:00 [entrez]
PHST- 2019/02/09 06:00 [pubmed]
PHST- 2019/05/28 06:00 [medline]
PHST- 2019/01/13 00:00 [pmc-release]
AID - 10.1155/2019/7491281 [doi]
PST - epublish
SO  - Biomed Res Int. 2019 Jan 13;2019:7491281. doi: 10.1155/2019/7491281. eCollection 
      2019.