PMID- 30734150
OWN - NLM
STAT- MEDLINE
DCOM- 20200504
LR  - 20240229
IS  - 1559-0259 (Electronic)
IS  - 1530-7905 (Print)
IS  - 1530-7905 (Linking)
VI  - 19
IP  - 4
DP  - 2019 Aug
TI  - Effect of Gestational Age on Maternofetal Vascular Function Following Single 
      Maternal Engineered Nanoparticle Exposure.
PG  - 321-333
LID - 10.1007/s12012-019-09505-0 [doi]
AB  - Normal pregnancy outcome is accomplished, in part, by rapid and expansive 
      physiological adaptations to the systemic circulation, the extent of which is 
      specific to gestational day (GD) and anatomical location. Pregnancy-related 
      hemodynamic changes in uterine placental blood flow stimulate compensatory 
      vascular signaling and remodeling that begins early and continues throughout 
      gestation. Exposure of the maternal environment to engineered nanomaterials (ENM) 
      during pregnancy has been shown to impact health of the dam, fetus, and adult 
      offspring; however, the consequences of specific temporal (gestational age) and 
      spatial (vascular location) considerations are largely undetermined. We exposed 
      pregnant Sprague-Dawley rats to nano-TiO(2) aerosols at three critical periods of 
      fetal development (GD 4, 12, and 17) to identify vascular perturbations 
      associated with ENM exposure at these developmental milestones. Vascular 
      reactivity of the maternal thoracic aorta, the uterine artery, the umbilical 
      vein, and the fetal thoracic aorta were evaluated using wire myography on GD 20. 
      While impairments were noted at each level of the maternofetal vascular tree and 
      at each exposure day, our results indicate the greatest effects may be identified 
      within the fetal vasculature (umbilical vein and fetal aorta), wherein effects of 
      a single maternal inhalational exposure to nano-TiO(2) on GD 4 modified responses 
      to cholinergic, NO, and alpha-adrenergic signaling.
FAU - Fournier, S B
AU  - Fournier SB
AD  - Environmental and Occupational Health Sciences Institute, 170 Frelinghuysen Rd, 
      Piscataway, NJ, 08854, USA.
FAU - Kallontzi, S
AU  - Kallontzi S
AD  - Materials Science and Engineering, Rutgers University, 607 Taylor Rd, Piscataway, 
      NJ, 08854, USA.
FAU - Fabris, L
AU  - Fabris L
AD  - Materials Science and Engineering, Rutgers University, 607 Taylor Rd, Piscataway, 
      NJ, 08854, USA.
FAU - Love, C
AU  - Love C
AD  - Biology and Environmental Studies, Grinnell College, 1116 Eighth Ave, Grinnell, 
      IA, 50112, USA.
FAU - Stapleton, P A
AU  - Stapleton PA
AD  - Environmental and Occupational Health Sciences Institute, 170 Frelinghuysen Rd, 
      Piscataway, NJ, 08854, USA. stapleton@eohsi.rutgers.edu.
AD  - Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, 
      Rutgers University, 160 Frelinghuysen Rd, Piscataway, NJ, 08854, USA. 
      stapleton@eohsi.rutgers.edu.
LA  - eng
GR  - P30 ES005022/ES/NIEHS NIH HHS/United States
GR  - R00 ES024783/ES/NIEHS NIH HHS/United States
GR  - R25 ES020721/ES/NIEHS NIH HHS/United States
GR  - T32 ES007148/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cardiovasc Toxicol
JT  - Cardiovascular toxicology
JID - 101135818
RN  - 0 (Aerosols)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Aerosols
MH  - Animals
MH  - Aorta, Thoracic/drug effects/embryology/physiopathology
MH  - Female
MH  - Fetus/*blood supply
MH  - Gestational Age
MH  - Hemodynamics/*drug effects
MH  - Inhalation Exposure
MH  - Maternal Exposure
MH  - Maternal-Fetal Exchange/drug effects
MH  - Metal Nanoparticles/*toxicity
MH  - Pregnancy
MH  - Rats, Sprague-Dawley
MH  - Risk Assessment
MH  - Titanium/*toxicity
MH  - Umbilical Arteries/drug effects/physiopathology
MH  - Uterine Artery/drug effects/physiopathology
PMC - PMC6642065
MID - NIHMS1038501
OTO - NOTNLM
OT  - Fetal aorta
OT  - Gestational exposure
OT  - Nanomaterials
OT  - Nanotoxicology
OT  - Umbilical vein
OT  - Uterine artery
OT  - Wire myography
EDAT- 2019/02/09 06:00
MHDA- 2020/05/06 06:00
PMCR- 2019/02/07
CRDT- 2019/02/09 06:00
PHST- 2019/02/09 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2019/02/09 06:00 [entrez]
PHST- 2019/02/07 00:00 [pmc-release]
AID - 10.1007/s12012-019-09505-0 [pii]
AID - 9505 [pii]
AID - 10.1007/s12012-019-09505-0 [doi]
PST - ppublish
SO  - Cardiovasc Toxicol. 2019 Aug;19(4):321-333. doi: 10.1007/s12012-019-09505-0.