PMID- 30734918
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 14
IP  - 4
DP  - 2020 Aug
TI  - Alterations in effective connectivity within the Papez circuit are correlated 
      with insulin resistance in T2DM patients without mild cognitive impairment.
PG  - 1238-1246
LID - 10.1007/s11682-019-00049-z [doi]
AB  - Insulin resistance (IR) can significantly affect the hippocampus, a component of 
      a larger memory circuit called the Papez circuit. This study was performed to 
      identify altered effective connectivity within the Papez circuit in type 2 
      diabetes mellitus (T2DM) patients without mild cognitive impairment (MCI) and to 
      determine the relationships between these alterations and IR. T2DM patients 
      without MCI (n = 105) and age-, sex-, and education-matched healthy controls 
      (n = 106) were included in this study. Granger causality analysis (GCA) with seed 
      regions in the hippocampus was performed to identify abnormal effective 
      connectivity in the brains of T2DM patients without MCI. Furthermore, correlation 
      analysis was conducted to detect the association between aberrant effective 
      connectivity and IR in T2DM patients without MCI. Compared to healthy controls, 
      T2DM patients without MCI demonstrated abnormal directional connectivity both to 
      and from the hippocampus; the main abnormalities were located in several brain 
      areas, including the cingulate cortex, amygdala, and prefrontal cortex, all of 
      which are components of the Papez circuit. This altered effective connectivity 
      network in the Papez circuit was correlated with IR in T2DM patients without MCI. 
      Effective connectivity network alterations within the Papez circuit occurred 
      prior to the appearance of mild cognitive deficits in T2DM patients and were 
      correlated with IR. The current study may improve our understanding of the 
      IR-related neurological mechanisms involved in T2DM.
FAU - Xia, Wenqing
AU  - Xia W
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      No.68, Changle Road, Nanjing, 210006, China.
FAU - Chen, Yu-Chen
AU  - Chen YC
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, 
      No.68, Changle Road, Nanjing, 210006, China.
FAU - Luo, Yong
AU  - Luo Y
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      No.68, Changle Road, Nanjing, 210006, China.
FAU - Zhang, Danfeng
AU  - Zhang D
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      No.68, Changle Road, Nanjing, 210006, China.
FAU - Chen, Huiyou
AU  - Chen H
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, 
      No.68, Changle Road, Nanjing, 210006, China.
FAU - Ma, Jianhua
AU  - Ma J
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      No.68, Changle Road, Nanjing, 210006, China. majianhua@china.com.
FAU - Yin, Xindao
AU  - Yin X
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, 
      No.68, Changle Road, Nanjing, 210006, China. y.163yy@163.com.
LA  - eng
GR  - 18KJB320007/Natural Science Research of Jiangsu Higher Education Institutions of 
      China/
GR  - YKK16140/Medical Science and Technology Development Foundation of Nanjing 
      Department of Health/
GR  - BE2017614/Jiangsu Provincial Special Program of Medical Science/
GR  - QNRC2016062/Youth Medical Talents of Jiangsu Province/
GR  - YY-079/14th ?Six Talent Peaks? Project of Jiangsu Province/
GR  - 81870563/National Natural Science Foundation of China/
PT  - Journal Article
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Cognitive Dysfunction
MH  - *Diabetes Mellitus, Type 2
MH  - Humans
MH  - *Insulin Resistance
MH  - Magnetic Resonance Imaging
OTO - NOTNLM
OT  - Effective connectivity
OT  - Insulin resistance
OT  - Papez circuit
OT  - Type 2 diabetes mellitus
EDAT- 2019/02/09 06:00
MHDA- 2021/04/28 06:00
CRDT- 2019/02/09 06:00
PHST- 2019/02/09 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2019/02/09 06:00 [entrez]
AID - 10.1007/s11682-019-00049-z [pii]
AID - 10.1007/s11682-019-00049-z [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2020 Aug;14(4):1238-1246. doi: 10.1007/s11682-019-00049-z.