PMID- 30735074
OWN - NLM
STAT- MEDLINE
DCOM- 20200214
LR  - 20231116
IS  - 1522-1539 (Electronic)
IS  - 0363-6135 (Print)
IS  - 0363-6135 (Linking)
VI  - 316
IP  - 4
DP  - 2019 Apr 1
TI  - Left ventricular vortex and intraventricular pressure difference in dogs under 
      various loading conditions.
PG  - H882-H888
LID - 10.1152/ajpheart.00686.2018 [doi]
AB  - Restrictions on the conventional evaluation of diastolic function have been 
      recognized, especially under various loading conditions. Recently, new 
      noninvasive ventricular vortex indexes have been introduced and are expected to 
      reflect the cardiac function. Physiologically, there is a hypothesis that the 
      intraventricular pressure difference (IVPD) is related to the formation of 
      vortexes. IVPD and vortex indexes were simultaneously measured, and the 
      relationship between the two was investigated. To verify the possibility of 
      diastolic vorticity as an index of diastolic relaxation, a correlation between 
      diastolic vorticity and the load dependency of vorticity [time constant (tau)] was 
      examined. Six healthy dogs were studied using transthoracic echocardiography, 
      pressure, and a conductance catheter. Vorticity was analyzed using vector flow 
      mapping (VFM). IVPD was determined using Euler's equation with color M-mode 
      Doppler images. Data were obtained at baseline, at balloon dilatation in the 
      thoracic aorta to alter afterload, at hydroxyethyl starch infusion to alter 
      preload, and at milrinone administration to alter ventricular relaxation. Peak 
      vorticity at early diastole (E-Vor) and IVPD of the midventricle (MIVPD) 
      decreased under pressure loading, were unchanged under volume loading, and 
      increased during milrinone administration. In multivariate analysis, the 
      independent predictors of tau were global longitudinal strain, strain rate at early 
      diastole, and E-Vor. MIVPD was strongly correlated with E-Vor ( r = 0.84). 
      VFM-derived peak E vorticity was strongly related to IVPD, especially MIVPD, 
      under various loading conditions. Both of these novel indexes are promising as 
      reliable indexes of ventricular relaxation, independent from preload. NEW & 
      NOTEWORTHY We showed the close relationship of vortex and intraventricular 
      pressure difference and showed that both of them can become new markers of the 
      left ventricular relaxation property. Our present study creates a paradigm for 
      future studies in the field of intraventircular flow physiology and clinical 
      diastology.
FAU - Matsuura, Katsuhiro
AU  - Matsuura K
AUID- ORCID: 0000-0002-6047-2865
AD  - Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo 
      University of Agriculture and Technology , Tokyo , Japan.
FAU - Shiraishi, Kenjirou
AU  - Shiraishi K
AD  - Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo 
      University of Agriculture and Technology , Tokyo , Japan.
FAU - Sato, Kotomi
AU  - Sato K
AD  - Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo 
      University of Agriculture and Technology , Tokyo , Japan.
FAU - Shimada, Kazumi
AU  - Shimada K
AD  - Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo 
      University of Agriculture and Technology , Tokyo , Japan.
FAU - Goya, Seijirow
AU  - Goya S
AD  - Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo 
      University of Agriculture and Technology , Tokyo , Japan.
FAU - Uemura, Akiko
AU  - Uemura A
AD  - Department of Animal Science, Faculty of Life and Environmental Science, TEIKYO 
      University of Science , Tokyo , Japan.
FAU - Ifuku, Mayumi
AU  - Ifuku M
AD  - Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate 
      School of Medicine , Tokyo , Japan.
FAU - Iso, Takeshi
AU  - Iso T
AD  - Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate 
      School of Medicine , Tokyo , Japan.
FAU - Takahashi, Ken
AU  - Takahashi K
AD  - Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate 
      School of Medicine , Tokyo , Japan.
FAU - Tanaka, Ryou
AU  - Tanaka R
AUID- ORCID: 0000-0001-9948-6490
AD  - Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo 
      University of Agriculture and Technology , Tokyo , Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190208
PL  - United States
TA  - Am J Physiol Heart Circ Physiol
JT  - American journal of physiology. Heart and circulatory physiology
JID - 100901228
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/physiopathology
MH  - Balloon Occlusion
MH  - Dogs
MH  - Female
MH  - Heart/*physiology/physiopathology
MH  - *Hemorheology
MH  - Myocardial Contraction
MH  - *Ventricular Function, Left
MH  - *Ventricular Pressure
PMC - PMC7002869
OTO - NOTNLM
OT  - intraventricular pressure gradient
OT  - noninvasive marker of ventricular relaxation
OT  - vector flow mapping
COIS- No conflicts of interest, financial or otherwise, are declared by the author(s).
EDAT- 2019/02/09 06:00
MHDA- 2020/02/15 06:00
PMCR- 2020/04/01
CRDT- 2019/02/09 06:00
PHST- 2019/02/09 06:00 [pubmed]
PHST- 2020/02/15 06:00 [medline]
PHST- 2019/02/09 06:00 [entrez]
PHST- 2020/04/01 00:00 [pmc-release]
AID - H-00686-2018 [pii]
AID - 10.1152/ajpheart.00686.2018 [doi]
PST - ppublish
SO  - Am J Physiol Heart Circ Physiol. 2019 Apr 1;316(4):H882-H888. doi: 
      10.1152/ajpheart.00686.2018. Epub 2019 Feb 8.