PMID- 30735785
OWN - NLM
STAT- MEDLINE
DCOM- 20190827
LR  - 20220108
IS  - 1089-8611 (Electronic)
IS  - 1089-8603 (Print)
IS  - 1089-8603 (Linking)
VI  - 86
DP  - 2019 May 1
TI  - Controlled light-induced gas phase nitric oxide release from S-nitrosothiol-doped 
      silicone rubber films.
PG  - 31-37
LID - S1089-8603(18)30274-X [pii]
LID - 10.1016/j.niox.2019.01.016 [doi]
AB  - The light induced nitric oxide (NO) release properties of 
      S-nitroso-N-acetylpenicillamine (SNAP) and S-nitrosoglutathione (GSNO) NO donors 
      doped within polydimethylsiloxane (PDMS) films (PDMS-SNAP and PDMS-GSNO 
      respectively) for potential inhaled NO (iNO) applications is examined. To achieve 
      photolytic release of gas phase NO from the PDMS-SNAP and PDMS-GSNO films, 
      narrow-band LED light sources are employed and the NO concentration in a N(2) 
      sweep gas above the film is monitored with an electrochemical NO sensor. The NO 
      release kinetics using LED sources with different nominal wavelengths and optical 
      power densities are reported. The effect of the NO donor loading within the PDMS 
      films is also examined. The NO release levels can be controlled by the LED 
      triggered release from the NO donor-doped silicone rubber films in order to 
      generate therapeutic levels in a sweep gas for suitable durations potentially 
      useful for iNO therapy. Hence this work may lay the groundwork for future 
      development of a highly portable iNO system for treatment of patients with 
      pulmonary hypertension, hypoxemia, and cystic fibrosis.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Lautner, Gergely
AU  - Lautner G
AD  - Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, 
      48109, USA; Department of Chemistry, University of Michigan, Ann Arbor, MI, 
      48109, USA.
FAU - Stringer, Blake
AU  - Stringer B
AD  - Department of Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
FAU - Brisbois, Elizabeth J
AU  - Brisbois EJ
AD  - Department of Materials Science and Engineering, University of Central Florida, 
      Orlando, FL, 32816, USA.
FAU - Meyerhoff, Mark E
AU  - Meyerhoff ME
AD  - Department of Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA. 
      Electronic address: mmeyerho@umich.edu.
FAU - Schwendeman, Steven P
AU  - Schwendeman SP
AD  - Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, 
      48109, USA; Department of Biomedical Engineering, University of Michigan, Ann 
      Arbor, MI, 48109, USA; Biointerfaces Institute, University of Michigan, Ann 
      Arbor, MI, 48109, USA. Electronic address: schwende@umich.edu.
LA  - eng
GR  - F32 HL127981/HL/NHLBI NIH HHS/United States
GR  - R21 EB024038/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190205
PL  - United States
TA  - Nitric Oxide
JT  - Nitric oxide : biology and chemistry
JID - 9709307
RN  - 0 (Drug Carriers)
RN  - 0 (Gases)
RN  - 0 (Membranes, Artificial)
RN  - 0 (Nitric Oxide Donors)
RN  - 0 (Silicones)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 57564-91-7 (S-Nitrosoglutathione)
RN  - 79032-48-7 (S-Nitroso-N-Acetylpenicillamine)
SB  - IM
MH  - Drug Carriers/*chemistry
MH  - Drug Liberation
MH  - Gases/chemistry
MH  - Kinetics
MH  - Membranes, Artificial
MH  - Nitric Oxide/*chemistry
MH  - Nitric Oxide Donors/*chemistry/radiation effects
MH  - S-Nitroso-N-Acetylpenicillamine/*chemistry/radiation effects
MH  - S-Nitrosoglutathione/*chemistry/radiation effects
MH  - Silicones/*chemistry
MH  - Ultraviolet Rays
PMC - PMC8740643
MID - NIHMS1763606
OTO - NOTNLM
OT  - GSNO
OT  - Gas phase
OT  - Inhalation NO
OT  - Nitric oxide
OT  - Photo release
OT  - S-nitrosothiol
OT  - SNAP
EDAT- 2019/02/09 06:00
MHDA- 2019/08/28 06:00
PMCR- 2022/01/07
CRDT- 2019/02/09 06:00
PHST- 2018/10/02 00:00 [received]
PHST- 2018/11/12 00:00 [revised]
PHST- 2019/01/31 00:00 [accepted]
PHST- 2019/02/09 06:00 [pubmed]
PHST- 2019/08/28 06:00 [medline]
PHST- 2019/02/09 06:00 [entrez]
PHST- 2022/01/07 00:00 [pmc-release]
AID - S1089-8603(18)30274-X [pii]
AID - 10.1016/j.niox.2019.01.016 [doi]
PST - ppublish
SO  - Nitric Oxide. 2019 May 1;86:31-37. doi: 10.1016/j.niox.2019.01.016. Epub 2019 Feb 
      5.