PMID- 30736202
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1744-8417 (Electronic)
IS  - 1744-6651 (Linking)
VI  - 9
IP  - 6
DP  - 2014 Nov
TI  - Defining the role of GLP-1 receptor agonists for individualized treatment of Type 
      2 diabetes.
PG  - 659-670
LID - 10.1586/17446651.2014.949672 [doi]
AB  - With the advent of dipeptidyl peptidase (DPP)-4 inhibitors and glucagon-like 
      peptide-1 receptor agonists (GLP-1 RAs) over the past decade, incretin therapy 
      has become established as an important treatment strategy for Type 2 diabetes 
      mellitus (T2DM), with an efficacy and safety profile distinct from that of other 
      anti-hyperglycemic agents. However, our understanding of the optimal clinical use 
      of incretins remains incomplete. This review focuses on the use of GLP-1 RAs in 
      the treatment of T2DM, with reference to the differing dominant mechanisms of 
      action between short- and long-acting GLP-1 RAs and the clinical implications of 
      this difference. The role of GLP-1 and the effects of GLP-1 RAs in various organs 
      other than the pancreas will also be discussed.
FAU - Yabe, Daisuke
AU  - Yabe D
AD  - a Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power 
      Hospital, Osaka, Japan.
AD  - b Center for Metabolism and Clinical Nutrition, Kansai Electric Power Hospital, 
      Osaka, Japan.
AD  - c Division of Molecular and Metabolic Medicine, Kobe University Graduate School 
      of Medicine, Kobe, Japan.
FAU - Seino, Yutaka
AU  - Seino Y
AD  - a Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power 
      Hospital, Osaka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140903
PL  - England
TA  - Expert Rev Endocrinol Metab
JT  - Expert review of endocrinology & metabolism
JID - 101278293
OTO - NOTNLM
OT  - DPP-4 inhibitor
OT  - GLP-1 receptor agonist
OT  - Type 2 diabetes
OT  - albiglutide
OT  - dulaglutide
OT  - exenatide
OT  - exenatide LAR
OT  - incretin
OT  - liraglutide
OT  - lixisenatide
EDAT- 2014/11/01 00:00
MHDA- 2014/11/01 00:01
CRDT- 2019/02/10 06:00
PHST- 2019/02/10 06:00 [entrez]
PHST- 2014/11/01 00:00 [pubmed]
PHST- 2014/11/01 00:01 [medline]
AID - 10.1586/17446651.2014.949672 [doi]
PST - ppublish
SO  - Expert Rev Endocrinol Metab. 2014 Nov;9(6):659-670. doi: 
      10.1586/17446651.2014.949672. Epub 2014 Sep 3.