PMID- 30736474
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 8
IP  - 2
DP  - 2019 Feb 7
TI  - Effects of Different Comorbidities on Health-Related Quality of Life among 
      Respiratory Patients in Vietnam.
LID - 10.3390/jcm8020214 [doi]
LID - 214
AB  - Comorbidities are common in respiratory disease patients and have been well-known 
      to impact their quality of life. The objective of this study is to estimate the 
      minimal clinically important difference (MCID) of the health-related quality of 
      life (HRQOL) among respiratory disease patients with different comorbidities in a 
      Vietnamese tertiary hospital. We performed a cross-sectional study from October 
      to November 2016 at the Respiratory Center of Bach Mai Hospital, Hanoi, with a 
      total of 508 participants. Information about socio-economic characteristics, 
      HRQOL and comorbidities of participants was collected. ANOVA was used to identify 
      MCID between patients with and without specific comorbid conditions. Tobit 
      regression was used to explore the associations between comorbidities and the 
      HRQOL. Results showed that the prevalence of cardiovascular comorbidities was 
      23.8%, followed by musculoskeletal diseases (12.0%), digestive diseases (11.8%), 
      endocrine diseases (10.0%), kidney diseases (5.1%) and ear, nose, and throat 
      diseases (4.5%). Regarding HRQOL, having a problem in pain/discomfort was 
      observed in 61.0% of participants, followed by anxiety/depression (48.2%). Mean 
      EQ-5D index was 0.66 (SD (Standard Deviation) = 0.31). The significant MCID (p < 
      0.05) was found between patients with and without cardiovascular diseases, 
      musculoskeletal diseases, kidney diseases, and endocrine diseases. The 
      multivariate regression model showed that only musculoskeletal diseases were 
      found to be related with the marked decrement of EQ-5D index score (Coef. = 
      -0.13; 95% CI (Confident Interval) = -0.23; -0.02). Suffering at least one 
      chronic illness was correlated to the marked decrease of EQ-5D index score (Coef. 
      = -0.09; 95%CI = -0.17; -0.01). These results underline the importance of 
      appropriate pain management as well as the provision of an interprofessional care 
      approach to patients in order to alleviate the burden of comorbidities to their 
      treatment outcomes and HRQOL.
FAU - Ngo, Chau Quy
AU  - Ngo CQ
AD  - Department of Internal Medicine, Hanoi Medical University, Hanoi 100000, Vietnam. 
      ngoquychaubmh@gmail.com.
FAU - Phan, Phuong Thu
AU  - Phan PT
AD  - Department of Internal Medicine, Hanoi Medical University, Hanoi 100000, Vietnam. 
      thuphuongdr@gmail.com.
FAU - Vu, Giap Van
AU  - Vu GV
AD  - Department of Internal Medicine, Hanoi Medical University, Hanoi 100000, Vietnam. 
      drgiap@hmu.edu.vn.
FAU - Pham, Quyen Le Thi
AU  - Pham QLT
AD  - Department of Internal Medicine, Hanoi Medical University, Hanoi 100000, Vietnam. 
      phamlequyenbmh@gmail.com.
FAU - Nguyen, Long Hoang
AU  - Nguyen LH
AD  - Center of Excellence in Behavioral Medicine, Nguyen Tat Thanh University, Ho Chi 
      Minh city, 700000, Vietnam. longnh.ph@gmail.com.
FAU - Vu, Giang Thu
AU  - Vu GT
AD  - Center of Excellence in Evidence-based Medicine, Nguyen Tat Thanh University, Ho 
      Chi Minh City, 700000, Vietnam. giang.coentt@gmail.com.
FAU - Tran, Tung Thanh
AU  - Tran TT
AD  - Center of Excellence in Evidence-based Medicine, Nguyen Tat Thanh University, Ho 
      Chi Minh City, 700000, Vietnam. tung.coentt@gmail.com.
FAU - Nguyen, Huong Lan Thi
AU  - Nguyen HLT
AD  - Institute for Global Health Innovations, Duy Tan University, Da Nang 550000, 
      Vietnam. huong.ighi@gmail.com.
FAU - Tran, Bach Xuan
AU  - Tran BX
AD  - Institute for Preventive Medicine and Public Health, Hanoi Medical University, 
      Hanoi 100000, Vietnam. bach.ipmph@gmail.com.
AD  - Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. 
      bach.ipmph@gmail.com.
FAU - Latkin, Carl A
AU  - Latkin CA
AD  - Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. 
      carl.latkin@jhu.edu.
FAU - Ho, Cyrus S H
AU  - Ho CSH
AD  - Department of Psychological MedTicine, National University Hospital, Singapore 
      119074, Singapore. cyrushosh@gmail.com.
FAU - Ho, Roger C M
AU  - Ho RCM
AD  - Center of Excellence in Behavioral Medicine, Nguyen Tat Thanh University, Ho Chi 
      Minh city, 700000, Vietnam. pcmrhcm@nus.edu.sg.
AD  - Department of Psychological Medicine, Yong Loo Lin School of Medicine, National 
      University of Singapore 119228, Singapore. pcmrhcm@nus.edu.sg.
LA  - eng
PT  - Journal Article
DEP - 20190207
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC6406871
OTO - NOTNLM
OT  - HRQOL
OT  - Vietnam
OT  - comorbidity
OT  - minimally clinically important difference
OT  - respiratory diseases
COIS- The authors declare no conflict of interest
EDAT- 2019/02/10 06:00
MHDA- 2019/02/10 06:01
PMCR- 2019/02/07
CRDT- 2019/02/10 06:00
PHST- 2018/11/06 00:00 [received]
PHST- 2019/01/31 00:00 [revised]
PHST- 2019/02/05 00:00 [accepted]
PHST- 2019/02/10 06:00 [entrez]
PHST- 2019/02/10 06:00 [pubmed]
PHST- 2019/02/10 06:01 [medline]
PHST- 2019/02/07 00:00 [pmc-release]
AID - jcm8020214 [pii]
AID - jcm-08-00214 [pii]
AID - 10.3390/jcm8020214 [doi]
PST - epublish
SO  - J Clin Med. 2019 Feb 7;8(2):214. doi: 10.3390/jcm8020214.