PMID- 30736987
OWN - NLM
STAT- MEDLINE
DCOM- 20190916
LR  - 20190916
IS  - 1773-0597 (Electronic)
IS  - 0181-5512 (Linking)
VI  - 42
IP  - 3
DP  - 2019 Mar
TI  - Correlations of blood lipids with early changes in macular thickness in patients 
      with diabetes.
PG  - 276-280
LID - S0181-5512(18)30537-0 [pii]
LID - 10.1016/j.jfo.2018.07.007 [doi]
AB  - PURPOSE: This study aimed to investigate the correlations of blood lipids with 
      changes in macular volume and thickness in patients with diabetes. METHODS: 
      Central subfield macular thickness (CSMT) and central subfield macular volume 
      (CSMV) were measured in 85 patients with type 2 diabetes (DM2) using 
      spectral-domain optical coherence tomography (SD-OCT). In addition, serum 
      creatinine (Cr), total cholesterol (TC), triglyceride (TG), high-density 
      lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), 
      glycated hemoglobin (HbA1c), and proteinuria were measured in all patients. 
      RESULTS: The mean CSMT of the 85 patients was 272.8+/-16.9mum, and CSMV was 
      215.1+/-14.6x10(-3)mm(3). TC, LDLC, HbA1c, and proteinuria were closely correlated 
      to CSMT, and HDLC, HbA1c, and proteinuria were correlated to CSMV. After 
      adjustment for sex, age, DM2 course, proteinuria, and HbA1c, LDLC was 
      significantly correlated to CSMT (95% confidence interval (CI), 1.93-11.05, 
      P=0.008) and CSMV (95% CI, 0.92-8.41, P=0.021); however, HDLC, TC, and TG showed 
      no significant correlation with CSMT or CSMV. CONCLUSIONS: Increased LDLC was 
      closely correlated to changes in CSMT and CSMV in early diabetic patients, and 
      increased CSMT was also accompanied by increased LDLC; therefore, this type of 
      patient would be more likely to develop macular edema.
CI  - Copyright (c) 2018. Published by Elsevier Masson SAS.
FAU - Liang, J
AU  - Liang J
AD  - Department of Ophthalmology, Central Hospital of Linyi, Linyi 276400, Shandong, 
      China.
FAU - Lei, W
AU  - Lei W
AD  - Department of Ophthalmology, Central Hospital of Linyi, Linyi 276400, Shandong, 
      China.
FAU - Cheng, J
AU  - Cheng J
AD  - Department of Ophthalmology, Central Hospital of Linyi, Linyi 276400, Shandong, 
      China. Electronic address: jintaochengdoc@126.com.
LA  - eng
PT  - Journal Article
DEP - 20190205
PL  - France
TA  - J Fr Ophtalmol
JT  - Journal francais d'ophtalmologie
JID - 7804128
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis/*pathology
MH  - Diabetic Retinopathy/blood/diagnosis/pathology
MH  - Disease Progression
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Lipids/*blood
MH  - Macula Lutea/diagnostic imaging/*pathology
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - Diabetic macular edema
OT  - Diabetic retinopathy
OT  - Macular thickness
OT  - OCT
OT  - Retinopathie diabetique
OT  - Epaisseur maculaire
OT  - OEdeme maculaire diabetique
EDAT- 2019/02/10 06:00
MHDA- 2019/09/17 06:00
CRDT- 2019/02/10 06:00
PHST- 2017/12/21 00:00 [received]
PHST- 2018/07/26 00:00 [revised]
PHST- 2018/07/26 00:00 [accepted]
PHST- 2019/02/10 06:00 [pubmed]
PHST- 2019/09/17 06:00 [medline]
PHST- 2019/02/10 06:00 [entrez]
AID - S0181-5512(18)30537-0 [pii]
AID - 10.1016/j.jfo.2018.07.007 [doi]
PST - ppublish
SO  - J Fr Ophtalmol. 2019 Mar;42(3):276-280. doi: 10.1016/j.jfo.2018.07.007. Epub 2019 
      Feb 5.