PMID- 30737993
OWN - NLM
STAT- MEDLINE
DCOM- 20200602
LR  - 20210109
IS  - 1542-474X (Electronic)
IS  - 1082-720X (Print)
IS  - 1082-720X (Linking)
VI  - 24
IP  - 4
DP  - 2019 Jul
TI  - Electrocardiographic measures of ventricular repolarization dispersion and 
      arrhythmic outcomes among ST elevation myocardial infarction patients with 
      pre-infarction angina undergoing primary percutaneous coronary intervention.
PG  - e12637
LID - 10.1111/anec.12637 [doi]
LID - e12637
AB  - BACKGROUND: Arrhythmias are considered one of the major causes of death in ST 
      elevation myocardial infarction (STEMI), particularly in the early in-hospital 
      phase. Pre-infarction angina (PIA) has been suggested to have a protective role. 
      OBJECTIVES: To study the difference in acute electrocardiographic findings 
      between STEMI patients with and without PIA and to assess the in-hospital 
      arrhythmias in both groups. MATERIAL AND METHODS: We prospectively enrolled 238 
      consecutive patients with STEMI. Patients were divided into two groups: those 
      with or without PIA. ECG data recorded and analyzed included ST-segment 
      resolution (STR) at 90 min, corrected QT interval (QTc) and dispersion (QTD), 
      T-peak-to-T-end interval (Tp-Te), and dispersion and Tp-Te/QT ratio. In-hospital 
      ventricular arrhythmias encountered in both groups were recorded. Predictors of 
      in-hospital arrhythmias were assessed among different clinical and 
      electrocardiographic parameters. RESULTS: Of the 238 patients included, 42 (17%) 
      had PIA and 196 (83%) had no PIA. Patients with PIA had higher rates of STR 
      (p < 0.0001), while patients with no PIA had higher values of QTc (p = 0.006), 
      QTD (p = 0.001), Tp-Te interval (p = 0.001), Tp-Te dispersion (p < 0.0001), and 
      Tp-Te/QT ratio (p = 0.01) compared to those with angina preceding their incident 
      infarction (PIA). This was reflected into significantly higher rates of 
      in-hospital arrhythmias among patients with no PIA (20% vs. 7%, p = 0.04). 
      Furthermore, longer Tp-Te interval and higher Tp-Te/QT ratio independently 
      predicted in-hospital ventricular arrhythmias. CONCLUSION: Pre-infarction angina 
      patients had better electrocardiographic measures of repolarization dispersion 
      and encountered significantly less arrhythmic events compared to patients who did 
      not experience PIA.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Ahmed, Tarek A N
AU  - Ahmed TAN
AUID- ORCID: 0000-0003-4986-4849
AD  - Department of Cardiovascular Medicine, Asyut University Hospital, Asyut, Egypt.
FAU - Abdel-Nazeer, Amr A
AU  - Abdel-Nazeer AA
AD  - Department of Cardiovascular Medicine, Asyut University Hospital, Asyut, Egypt.
FAU - Hassan, Ayman K M
AU  - Hassan AKM
AD  - Department of Cardiovascular Medicine, Asyut University Hospital, Asyut, Egypt.
FAU - Hasan-Ali, Hosam
AU  - Hasan-Ali H
AD  - Department of Cardiovascular Medicine, Asyut University Hospital, Asyut, Egypt.
FAU - Youssef, Amr A
AU  - Youssef AA
AD  - Department of Cardiovascular Medicine, Asyut University Hospital, Asyut, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20190209
PL  - United States
TA  - Ann Noninvasive Electrocardiol
JT  - Annals of noninvasive electrocardiology : the official journal of the 
      International Society for Holter and Noninvasive Electrocardiology, Inc
JID - 9607443
SB  - IM
MH  - Angina Pectoris/complications/*physiopathology/therapy
MH  - Arrhythmias, Cardiac/complications/*physiopathology/therapy
MH  - Electrocardiography/*methods
MH  - Female
MH  - Heart Ventricles/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention/*methods
MH  - Prospective Studies
MH  - ST Elevation Myocardial Infarction/complications/*physiopathology/*therapy
PMC - PMC6931689
EDAT- 2019/02/10 06:00
MHDA- 2020/06/03 06:00
PMCR- 2019/02/09
CRDT- 2019/02/10 06:00
PHST- 2018/10/07 00:00 [received]
PHST- 2018/12/06 00:00 [revised]
PHST- 2018/12/28 00:00 [accepted]
PHST- 2019/02/10 06:00 [pubmed]
PHST- 2020/06/03 06:00 [medline]
PHST- 2019/02/10 06:00 [entrez]
PHST- 2019/02/09 00:00 [pmc-release]
AID - ANEC12637 [pii]
AID - 10.1111/anec.12637 [doi]
PST - ppublish
SO  - Ann Noninvasive Electrocardiol. 2019 Jul;24(4):e12637. doi: 10.1111/anec.12637. 
      Epub 2019 Feb 9.