PMID- 30738742
OWN - NLM
STAT- MEDLINE
DCOM- 20200113
LR  - 20200309
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Print)
IS  - 1438-4639 (Linking)
VI  - 222
IP  - 2
DP  - 2019 Mar
TI  - Preliminary assessment of exposure to persistent organic pollutants among 
      pregnant women in Puerto Rico.
PG  - 327-331
LID - S1438-4639(18)30880-0 [pii]
LID - 10.1016/j.ijheh.2019.02.001 [doi]
AB  - BACKGROUND: Puerto Rico has over 200 hazardous waste sites, as well as higher 
      rates of several adverse health outcomes compared to the mainland US. In response 
      to concerns of potential links between environmental contaminant exposure and 
      preterm birth, the Puerto Rico Testsite for Exploring Contamination Threats 
      (PROTECT) birth cohort was formed. Biomarkers of exposure for several 
      contaminants have been found to be elevated in this cohort compared to women of 
      child-bearing age in the National Health and Nutrition Examination Survey 
      (NHANES). However, exposure to persistent organic pollutants (POPs) has not been 
      evaluated. METHODS: In this preliminary analysis, we measured four classes of 
      POPs, including perfluoroalkyl substances (PFASs), polybrominated diphenyl ethers 
      (PBDEs), polychlorinated biphenyls (PCBs), and several persistent pesticides in 
      serum samples collected at 16-20 weeks gestation from the first 48 women enrolled 
      in PROTECT. We performed descriptive analyses for each analyte, assessed 
      correlations between analytes using Spearman correlations, and compared serum 
      levels in PROTECT women to levels in NHANES women aged 18-40. RESULTS: Several 
      PFASs were detected in 96-100% of samples, with moderate to strong correlations 
      between most PFASs (range r = 0.44-0.88). BDE47, BDE153, PCB 138-158, PCB153 and 
      p,p'-dichlorodiphenyldichloroethene (p,p'-DDE) were detected in the majority of 
      samples, with strong correlations between PCBs and p,p'-DDE (range 
      r = 0.59-0.74). The median concentration for each analyte was lower than, 
      sometimes by a factor of 4 (e.g. BDE47, p,p'-DDE), the median concentration 
      reported in NHANES women aged 18-40. CONCLUSION: Although participants in the 
      ongoing PROTECT birth cohort have higher exposure to many environmental 
      contaminants, this preliminary study suggests that they have lower exposure to 
      several POPS, specifically PCBs, OCPs, PFASs, and PBDEs.
CI  - Copyright (c) 2019 Elsevier GmbH. All rights reserved.
FAU - Watkins, Deborah J
AU  - Watkins DJ
AD  - Department of Environmental Health Sciences, University of Michigan School of 
      Public Health, Ann Arbor, MI, USA. Electronic address: debjwat@umich.edu.
FAU - Velez-Vega, Carmen M
AU  - Velez-Vega CM
AD  - University of Puerto Rico Graduate School of Public Health, Medical Sciences 
      Campus, San Juan, PR, USA.
FAU - Rosario, Zaira
AU  - Rosario Z
AD  - University of Puerto Rico Graduate School of Public Health, Medical Sciences 
      Campus, San Juan, PR, USA.
FAU - Cordero, Jose F
AU  - Cordero JF
AD  - Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA, 
      USA.
FAU - Alshawabkeh, Akram N
AU  - Alshawabkeh AN
AD  - College of Engineering, Northeastern University, Boston, MA, USA.
FAU - Meeker, John D
AU  - Meeker JD
AD  - Department of Environmental Health Sciences, University of Michigan School of 
      Public Health, Ann Arbor, MI, USA.
LA  - eng
GR  - P42 ES017198/ES/NIEHS NIH HHS/United States
GR  - P50 ES026049/ES/NIEHS NIH HHS/United States
GR  - T42 OH008455/OH/NIOSH CDC HHS/United States
GR  - UG3 OD023251/OD/NIH HHS/United States
GR  - UH3 OD023251/OD/NIH HHS/United States
GR  - R836155/EPA/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20190207
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Environmental Pollutants)
RN  - 0 (Flame Retardants)
RN  - 0 (Organic Chemicals)
RN  - 0 (Pesticides)
SB  - IM
MH  - Adult
MH  - Biological Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Flame Retardants/analysis
MH  - Humans
MH  - Organic Chemicals/*blood
MH  - Pesticides/blood
MH  - Pregnancy/*blood
MH  - Puerto Rico
PMC - PMC6408968
MID - NIHMS1521006
OTO - NOTNLM
OT  - Organochlorine pesticides (OCPs)
OT  - Per- and polyfluoroalkyl substances (PFASs)
OT  - Persistent organic pollutants
OT  - Polybrominated diphenyl ethers (PBDEs)
OT  - Polychlorinated biphenyls (PCBs)
OT  - Puerto Rico
EDAT- 2019/02/11 06:00
MHDA- 2020/01/14 06:00
PMCR- 2020/03/01
CRDT- 2019/02/11 06:00
PHST- 2018/10/25 00:00 [received]
PHST- 2019/01/23 00:00 [revised]
PHST- 2019/02/01 00:00 [accepted]
PHST- 2019/02/11 06:00 [pubmed]
PHST- 2020/01/14 06:00 [medline]
PHST- 2019/02/11 06:00 [entrez]
PHST- 2020/03/01 00:00 [pmc-release]
AID - S1438-4639(18)30880-0 [pii]
AID - 10.1016/j.ijheh.2019.02.001 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2019 Mar;222(2):327-331. doi: 
      10.1016/j.ijheh.2019.02.001. Epub 2019 Feb 7.