PMID- 30738951
OWN - NLM
STAT- MEDLINE
DCOM- 20191213
LR  - 20191217
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 485
DP  - 2019 Apr 5
TI  - Effects of stanniocalcin hormones on rat brown adipose tissue metabolism under 
      fed and fasted conditions.
PG  - 81-87
LID - S0303-7207(19)30048-6 [pii]
LID - 10.1016/j.mce.2019.02.004 [doi]
AB  - In this study we determined the effect of fed and fasting (48 h) states on the 
      expression of stanniocalcin-1 (Stc1) and stanniocalcin-2 (Stc2) in rat brown 
      adipose tissue (BAT), as well as the in vitro effects of human stanniocalcin 1 
      and 2 (hSTC-1 and hSTC-2) hormones on lipid and glucose metabolism. In addition, 
      lactate, glycogen levels and hexokinase (HK) activity were determined. In fasting 
      Stc2 expression increased markedly. The targets of action of hSTC-1 and hSTC-2 
      were glucose uptake and oxidation as well as glycogen storage, controlling the 
      energetic metabolism in BAT. The reduction in glycogen concentration induced by 
      hSTC-2 in fed state might have deleterious consequences in BAT, such as decreased 
      thermogenic activity, FA esterification and other adipocyte functions. On the 
      other hand, the increase of glucose uptake caused by hSTC-1 of fed rats could 
      play a role as a plasma glucose-clearing hormone in the postprandial period.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Sarapio, Elaine
AU  - Sarapio E
AD  - Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto 
      Alegre, RS, Brazil. Electronic address: elainesarapio@gmail.com.
FAU - Souza, Samir Khal
AU  - Souza SK
AD  - Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto 
      Alegre, RS, Brazil.
FAU - Vogt, Everton Lopes
AU  - Vogt EL
AD  - Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto 
      Alegre, RS, Brazil.
FAU - Rocha, Debora Santos
AU  - Rocha DS
AD  - Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto 
      Alegre, RS, Brazil.
FAU - Fabres, Rafael Bandeira
AU  - Fabres RB
AD  - Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto 
      Alegre, RS, Brazil.
FAU - Trapp, Marcia
AU  - Trapp M
AD  - Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto 
      Alegre, RS, Brazil.
FAU - Da Silva, Roselis S M
AU  - Da Silva RSM
AD  - Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto 
      Alegre, RS, Brazil. Electronic address: roselis@ufrgs.br.
LA  - eng
PT  - Journal Article
DEP - 20190207
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Glycoproteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (STC2 protein, human)
RN  - 0 (Stc2 protein, rat)
RN  - 76687-96-2 (teleocalcin)
RN  - 9005-79-2 (Glycogen)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adipose Tissue, Brown/*metabolism
MH  - Animals
MH  - Fasting
MH  - Glucose/*metabolism
MH  - Glycogen/metabolism
MH  - Glycoproteins/*genetics/metabolism
MH  - Hexokinase/metabolism
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*genetics/metabolism
MH  - Lipid Metabolism
MH  - Male
MH  - Postprandial Period
MH  - Rats
MH  - Rats, Wistar
MH  - Thermogenesis
EDAT- 2019/02/11 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/02/11 06:00
PHST- 2018/10/31 00:00 [received]
PHST- 2019/01/23 00:00 [revised]
PHST- 2019/02/04 00:00 [accepted]
PHST- 2019/02/11 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/02/11 06:00 [entrez]
AID - S0303-7207(19)30048-6 [pii]
AID - 10.1016/j.mce.2019.02.004 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2019 Apr 5;485:81-87. doi: 10.1016/j.mce.2019.02.004. Epub 
      2019 Feb 7.