PMID- 30738993
OWN - NLM
STAT- MEDLINE
DCOM- 20190705
LR  - 20190705
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 69
DP  - 2019 Apr
TI  - Oral cholecalciferol supplementation alleviates lipopolysaccharide-induced 
      preterm delivery partially through regulating placental steroid hormones and 
      prostaglandins in mice.
PG  - 235-244
LID - S1567-5769(19)30051-7 [pii]
LID - 10.1016/j.intimp.2019.01.052 [doi]
AB  - Several epidemiological reports demonstrated that vitamin D deficiency elevated 
      risk of preterm delivery. We investigate the effects of oral cholecalciferol 
      (VD3) supplementation on lipopolysaccharide (LPS)-induced preterm delivery. 
      Pregnant mice were randomly assigned to either oral VD3 (25 mug/kg) or corn oil 
      once daily from gestational day (GD)13 to GD15, and were intraperitoneally 
      injected with either LPS (200 mug/kg) or normal saline on GD15. As expected, LPS 
      was effective in inducing preterm delivery and fetal death. LPS-induced preterm 
      delivery and fetal death were alleviated in VD3-pretreated mice. LPS-induced 
      down-regulation of genes for placental progesterone biosynthetic enzymes was 
      blocked in VD3-pretreated mice. LPS-induced reduction of serum progesterone was 
      correspondingly attenuated by VD3. Although oral VD3 had no effect on estradiol 
      production, it attenuated LPS-induced up-regulation of placental ERbeta in mice. 
      LPS-induced placental COX-2 up-regulation and serum PGF2alpha elevation were 
      alleviated in VD3-pretreated mice. Additionally, LPS-evoked elevations of the 
      placental Tnfalpha, Il1beta, Mcp1 and Mip2 mRNAs were attenuated by VD3. VD3 promoted 
      placental vitamin D receptor nuclear translocation and simultaneously alleviated 
      LPS-induced nuclear translocation of NF-kappaB p65 and p50 subunits. These results 
      provide evidence that oral VD3 supplementation alleviates LPS-induced preterm 
      delivery and fetal demise partially through regulating placental steroid hormones 
      and prostaglandins.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Fu, Lin
AU  - Fu L
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China; Key 
      Laboratory of Environmental Toxicology, Anhui Higher Education Institutes, Anhui 
      Medical University, Hefei 230032, China; Anhui Provincial Key Laboratory of 
      Population Health & Aristogenics, Hefei 230032, China.
FAU - Chen, Yuan-Hua
AU  - Chen YH
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China; Key 
      Laboratory of Environmental Toxicology, Anhui Higher Education Institutes, Anhui 
      Medical University, Hefei 230032, China; Department of Histology and Embryology, 
      Anhui Medical University, Hefei 230032, China. Electronic address: 
      yuanhuach@126.com.
FAU - Xu, Shen
AU  - Xu S
AD  - Second Affiliated Hospital, Anhui Medical University, Hefei 230032, China.
FAU - Yu, Zhen
AU  - Yu Z
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China; Anhui 
      Provincial Key Laboratory of Population Health & Aristogenics, Hefei 230032, 
      China.
FAU - Zhang, Zhi-Hui
AU  - Zhang ZH
AD  - Second Affiliated Hospital, Anhui Medical University, Hefei 230032, China.
FAU - Zhang, Cheng
AU  - Zhang C
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China; Key 
      Laboratory of Environmental Toxicology, Anhui Higher Education Institutes, Anhui 
      Medical University, Hefei 230032, China; Anhui Provincial Key Laboratory of 
      Population Health & Aristogenics, Hefei 230032, China.
FAU - Wang, Hua
AU  - Wang H
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China; Key 
      Laboratory of Environmental Toxicology, Anhui Higher Education Institutes, Anhui 
      Medical University, Hefei 230032, China; Anhui Provincial Key Laboratory of 
      Population Health & Aristogenics, Hefei 230032, China.
FAU - Xu, De-Xiang
AU  - Xu DX
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China; Key 
      Laboratory of Environmental Toxicology, Anhui Higher Education Institutes, Anhui 
      Medical University, Hefei 230032, China; Anhui Provincial Key Laboratory of 
      Population Health & Aristogenics, Hefei 230032, China. Electronic address: 
      xudex@126.com.
LA  - eng
PT  - Journal Article
DEP - 20190207
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Prostaglandins)
RN  - 0 (Receptors, Calcitriol)
RN  - 1C6V77QF41 (Cholecalciferol)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Cholecalciferol/*therapeutic use
MH  - *Dietary Supplements
MH  - Estradiol/metabolism
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Lipopolysaccharides/immunology
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Placenta/*metabolism
MH  - Pregnancy
MH  - Premature Birth/*diet therapy
MH  - Progesterone/metabolism
MH  - Prostaglandins/metabolism
MH  - Receptors, Calcitriol/*metabolism
OTO - NOTNLM
OT  - Cholecalciferol
OT  - Inflammation
OT  - Lipopolysaccharide
OT  - Preterm delivery
OT  - Vitamin D receptor
EDAT- 2019/02/11 06:00
MHDA- 2019/07/06 06:00
CRDT- 2019/02/11 06:00
PHST- 2019/01/08 00:00 [received]
PHST- 2019/01/24 00:00 [revised]
PHST- 2019/01/30 00:00 [accepted]
PHST- 2019/02/11 06:00 [pubmed]
PHST- 2019/07/06 06:00 [medline]
PHST- 2019/02/11 06:00 [entrez]
AID - S1567-5769(19)30051-7 [pii]
AID - 10.1016/j.intimp.2019.01.052 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2019 Apr;69:235-244. doi: 10.1016/j.intimp.2019.01.052. Epub 
      2019 Feb 7.