PMID- 30739222 OWN - NLM STAT- MEDLINE DCOM- 20190806 LR - 20210109 IS - 1573-3432 (Electronic) IS - 0162-3257 (Print) IS - 0162-3257 (Linking) VI - 49 IP - 6 DP - 2019 Jun TI - ASD Screening with the Child Behavior Checklist/1.5-5 in the Study to Explore Early Development. PG - 2348-2357 LID - 10.1007/s10803-019-03895-4 [doi] AB - We analyzed CBCL/1(1/2)-5 Pervasive Developmental Problems (DSM-PDP) scores in 3- to 5-year-olds from the Study to Explore Early Development (SEED), a multi-site case control study, with the objective to discriminate children with ASD (N = 656) from children with Developmental Delay (DD) (N = 646), children with Developmental Delay (DD) plus ASD features (DD-AF) (N = 284), and population controls (POP) (N = 827). ASD diagnosis was confirmed with the ADOS and ADI-R. With a cut-point of T >/= 65, sensitivity was 80% for ASD, with specificity varying across groups: POP (0.93), DD-noAF (0.85), and DD-AF (0.50). One-way ANOVA yielded a large group effect (eta(2) = 0.50). Our results support the CBCL/1(1/2)-5's as a time-efficient ASD screener for identifying preschoolers needing further evaluation. FAU - Levy, Susan E AU - Levy SE AUID- ORCID: 0000-0001-5204-5655 AD - Center for Autism Research, Roberts Research Center, Children's Hospital of Philadelphia, 2716 South Street, Room 4361, Philadelphia, PA, 19146, USA. levys@email.chop.edu. AD - University of Pennsylvania, Philadelphia, PA, USA. levys@email.chop.edu. FAU - Rescorla, Leslie A AU - Rescorla LA AD - Bryn Mawr College, Bryn Mawr, PA, USA. FAU - Chittams, Jesse L AU - Chittams JL AD - University of Pennsylvania, Philadelphia, PA, USA. FAU - Kral, Tanja J AU - Kral TJ AD - University of Pennsylvania, Philadelphia, PA, USA. FAU - Moody, Eric J AU - Moody EJ AD - Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO, USA. FAU - Pandey, Juhi AU - Pandey J AD - Center for Autism Research, Roberts Research Center, Children's Hospital of Philadelphia, 2716 South Street, Room 4361, Philadelphia, PA, 19146, USA. AD - University of Pennsylvania, Philadelphia, PA, USA. FAU - Pinto-Martin, Jennifer A AU - Pinto-Martin JA AD - University of Pennsylvania, Philadelphia, PA, USA. FAU - Pomykacz, Alison T AU - Pomykacz AT AD - Center for Autism Research, Roberts Research Center, Children's Hospital of Philadelphia, 2716 South Street, Room 4361, Philadelphia, PA, 19146, USA. FAU - Ramirez, AnnJosette AU - Ramirez A AD - University of Pennsylvania, Philadelphia, PA, USA. AD - Thomas Jefferson University, Philadelphia, PA, USA. FAU - Reyes, Nuri AU - Reyes N AD - Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO, USA. FAU - Rosenberg, Cordelia Robinson AU - Rosenberg CR AD - Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO, USA. FAU - Schieve, Laura AU - Schieve L AD - Centers for Disease Control and Prevention, Atlanta, GA, USA. FAU - Thompson, Aleda AU - Thompson A AD - University of Pennsylvania, Philadelphia, PA, USA. FAU - Young, Lisa AU - Young L AD - University of Pennsylvania, Philadelphia, PA, USA. AD - Temple University, Philadelphia, PA, USA. FAU - Zhang, Jing AU - Zhang J AD - University of Pennsylvania, Philadelphia, PA, USA. FAU - Wiggins, Lisa AU - Wiggins L AD - Centers for Disease Control and Prevention, Atlanta, GA, USA. LA - eng GR - U10 DD000180/DD/NCBDD CDC HHS/United States GR - U10 DD000181/DD/NCBDD CDC HHS/United States GR - U10 DD000184/DD/NCBDD CDC HHS/United States GR - CC999999/ImCDC/Intramural CDC HHS/United States GR - U10 DD000183/DD/NCBDD CDC HHS/United States GR - U01 DD001210/DD/NCBDD CDC HHS/United States GR - P30 ES013508/ES/NIEHS NIH HHS/United States GR - U01 DD000498/DD/NCBDD CDC HHS/United States GR - U10DD000180/DD/NCBDD CDC HHS/United States GR - U10 DD000182/DD/NCBDD CDC HHS/United States PT - Journal Article PT - Multicenter Study PL - United States TA - J Autism Dev Disord JT - Journal of autism and developmental disorders JID - 7904301 MH - Autism Spectrum Disorder/*diagnosis/*psychology MH - Case-Control Studies MH - Checklist/*methods MH - Child MH - Child Behavior/*psychology MH - Child, Preschool MH - Developmental Disabilities/diagnosis/psychology MH - Female MH - Humans MH - Male MH - Mass Screening/*methods PMC - PMC7031768 MID - NIHMS1068842 OTO - NOTNLM OT - Autism spectrum disorder (ASD) OT - Child Behavior Checklist (CBCL) OT - Developmental delay (DD) COIS- Conflict of interest Dr. Rescorla receives remuneration from the University of Vermont Research Center for Children, Youth, and Families, which publishes the CBCL/1.5-5. The other authors have no financial relationships relevant to this article to disclose. EDAT- 2019/02/11 06:00 MHDA- 2019/08/07 06:00 PMCR- 2020/06/01 CRDT- 2019/02/11 06:00 PHST- 2019/02/11 06:00 [pubmed] PHST- 2019/08/07 06:00 [medline] PHST- 2019/02/11 06:00 [entrez] PHST- 2020/06/01 00:00 [pmc-release] AID - 10.1007/s10803-019-03895-4 [pii] AID - 10.1007/s10803-019-03895-4 [doi] PST - ppublish SO - J Autism Dev Disord. 2019 Jun;49(6):2348-2357. doi: 10.1007/s10803-019-03895-4.