PMID- 30740171
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1857-9655 (Print)
IS  - 1857-9655 (Electronic)
IS  - 1857-9655 (Linking)
VI  - 7
IP  - 1
DP  - 2019 Jan 15
TI  - Predictors of Renal Dysfunction in Adults with Childhood Vesicoureteral Reflux 
      after Long-Term Follow-Up.
PG  - 107-113
LID - 10.3889/oamjms.2019.078 [doi]
AB  - BACKGROUND: Triad of childhood vesicoureteral reflux (VUR), urinary infection 
      (UTI) and renal scarring might initiate potentially serious consequences that 
      lead to renal dysfunction manifested at the second or third decade of life. AIM: 
      To identify the risk factors predictive for renal dysfunction in adults with 
      primary VUR after long-term follow-up. METHODS: We evaluated the records of 101 
      children (94.1% female, 5.9% male) at a median age of 5.2 +/- 2.3 years (1-12 
      years), suffering from UTI and VUR. The patients were interviewed after mean 21 
      years from the first episodes of VUR (8 to 32 years). Renal function was 
      determined from the estimated glomerular filtration rate (eGFR). RESULTS: Renal 
      scarring was detected in 68.3% out of 82 patients and bilateral one in 7.3% 
      patients. Linear regression analysis revealed that presence of proteinuria (B = 
      -33.7, p=0.0001), the greater number of years from VUR diagnosis (B = -1.6, p = 
      0.002) and renal scarring (B = -14.8, p = 0.005) appeared as independent 
      predictors of reduced global eGFRcreat. The same variables plus microalbuminuria 
      (B = -1.0, p = 0.012) appeared as independent predictors of reduced global 
      eGFRcreat-cys. Bilateral scarring (OR=25.5, p = 0.003) appeared as independent 
      predictor of greater risk for CKD assessed using eGFRcreat while greater number 
      of years from VUR diagnosis (OR = 1.7, p = 0.092), microalbuminuria (OR = 1.3, p 
      = 0.047) and again bilateral scarring (OR = 31.3, p = 0.040) appeared as 
      predictors of risk for CKD assessed using eGFRcreat-cys. CONCLUSION: 
      Identification of those with an increased risk of progression to CKD should be 
      the goal in all patients with childhood VUR. Their systematic follow-up should be 
      till adulthood and older age.
FAU - Bundovska-Kocev, Smiljana
AU  - Bundovska-Kocev S
AD  - University Clinic of Radiotherapy & Oncology, Medical School, University Ss. 
      Cyril and Methodius of Skopje, Skopje, Republic of Macedonia.
FAU - Kuzmanovska, Dafina
AU  - Kuzmanovska D
AD  - University Paediatric Clinic, Medical School, University Ss. Cyril and Methodius 
      of Skopje, Skopje, Republic of Macedonia.
FAU - Selim, Gjulsen
AU  - Selim G
AD  - University Clinic of Nephrology, Medical School, University Ss. Cyril and 
      Methodius of Skopje, Skopje, Republic of Macedonia.
FAU - Georgievska-Ismail, Ljubica
AU  - Georgievska-Ismail L
AD  - University Clinic of Cardiology, Medical School, University Ss. Cyril and 
      Methodius of Skopje, Skopje, Republic of Macedonia.
LA  - eng
PT  - Journal Article
DEP - 20190114
PL  - North Macedonia
TA  - Open Access Maced J Med Sci
JT  - Open access Macedonian journal of medical sciences
JID - 101662294
PMC - PMC6352487
OTO - NOTNLM
OT  - Childhood vesicoureteral reflux
OT  - Chronic renal failure
OT  - Predictive risk factors
OT  - Renal dysfunction
EDAT- 2019/02/12 06:00
MHDA- 2019/02/12 06:01
PMCR- 2019/01/14
CRDT- 2019/02/12 06:00
PHST- 2018/12/04 00:00 [received]
PHST- 2019/01/02 00:00 [revised]
PHST- 2019/01/03 00:00 [accepted]
PHST- 2019/02/12 06:00 [entrez]
PHST- 2019/02/12 06:00 [pubmed]
PHST- 2019/02/12 06:01 [medline]
PHST- 2019/01/14 00:00 [pmc-release]
AID - OAMJMS-7-107 [pii]
AID - 10.3889/oamjms.2019.078 [doi]
PST - epublish
SO  - Open Access Maced J Med Sci. 2019 Jan 14;7(1):107-113. doi: 
      10.3889/oamjms.2019.078. eCollection 2019 Jan 15.