PMID- 30740259
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2214-0883 (Electronic)
IS  - 2095-1779 (Print)
IS  - 2214-0883 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Feb
TI  - Development of a microcomposite with single-walled carbon nanotubes and Nd(2)O(3) 
      for determination of paracetamol in pharmaceutical dosage by adsorptive 
      voltammetry.
PG  - 62-69
LID - 10.1016/j.jpha.2018.11.005 [doi]
AB  - This study presents for the first time a new composite of carbon paste (CP), 
      single-walled carbon nanotubes (SWCNTs) and Nd(2)O(3) (Nd(OX)). This versatile 
      composite (Nd(OX)-SWCNT/CPE) was applied to the oxidation of paracetamol (PCM). 
      The newly formed surface was characterized by scanning electron microscopy (SEM), 
      electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The 
      results showed greater conductivity and a higher surface area for the composite 
      than those of the carbon paste alone. Moreover, the anodic peak currents for PCM 
      increased from 1.6 to 3.6 microA with CPE and Nd(OX)-SWCNT/CPE, indicating an 
      increase of nearly 51.0% for the anodic peak current. On the other hand, the 
      anodic peak potentials shifted from 0.67 to 0.57 V. The detection limits were 
      0.05 micromol/L with Nd(OX)-SWCNT/CPE and 0.50 micromol/L with SWCNT/CPE. The relative 
      standard deviations (RSDs) were 1.5% (n = 7). The accuracy and interference of 
      the methods were evaluated with a urine chemistry control spiked with known 
      quantities of PCM, uric acid, dopamine, ascorbic acid, caffeine, acetylsalicylic 
      acid, tartrazine, sunset yellow, allure red, rutin, morin and metal ions. 
      Finally, the novelty and usefulness of the composite were evaluated to quantify 
      PCM in pharmaceutical dosage forms such as tablets, powders and syrups for 
      children.
FAU - Arancibia, Veronica
AU  - Arancibia V
AD  - Pontificia Universidad Catolica de Chile, Facultad de Quimica, Vicuna Mackenna 
      4860, Santiago 7820436, Chile.
FAU - Penagos-Llanos, Johisner
AU  - Penagos-Llanos J
AD  - Facultad de Ciencias Naturales y Matematicas, Universidad de Ibague, Carrera 22 
      Calle 67, 730001 Ibague, Colombia.
FAU - Nagles, Edgar
AU  - Nagles E
AD  - Facultad de Ciencias Naturales y Matematicas, Universidad de Ibague, Carrera 22 
      Calle 67, 730001 Ibague, Colombia.
FAU - Garcia-Beltran, Olimpo
AU  - Garcia-Beltran O
AD  - Facultad de Ciencias Naturales y Matematicas, Universidad de Ibague, Carrera 22 
      Calle 67, 730001 Ibague, Colombia.
FAU - Hurtado, John J
AU  - Hurtado JJ
AD  - Departamento de Quimica, Universidad de los Andes, Carrera 1 No. 18A-12, Bogota, 
      Colombia.
LA  - eng
PT  - Journal Article
DEP - 20181122
PL  - China
TA  - J Pharm Anal
JT  - Journal of pharmaceutical analysis
JID - 101579451
PMC - PMC6355469
OTO - NOTNLM
OT  - Neodymium (III) Oxide
OT  - Paracetamol
OT  - Pharmaceutical dosage
OT  - Single-walled carbon nanotubes
EDAT- 2019/02/12 06:00
MHDA- 2019/02/12 06:01
PMCR- 2018/11/22
CRDT- 2019/02/12 06:00
PHST- 2018/10/13 00:00 [received]
PHST- 2018/11/20 00:00 [revised]
PHST- 2018/11/21 00:00 [accepted]
PHST- 2019/02/12 06:00 [entrez]
PHST- 2019/02/12 06:00 [pubmed]
PHST- 2019/02/12 06:01 [medline]
PHST- 2018/11/22 00:00 [pmc-release]
AID - S2095-1779(18)30387-3 [pii]
AID - 10.1016/j.jpha.2018.11.005 [doi]
PST - ppublish
SO  - J Pharm Anal. 2019 Feb;9(1):62-69. doi: 10.1016/j.jpha.2018.11.005. Epub 2018 Nov 
      22.