PMID- 30740354
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2233-8276 (Print)
IS  - 2233-8268 (Electronic)
IS  - 2233-8276 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Jan
TI  - Minimal clinically important difference for the rhinoconjunctivitis quality of 
      life questionnaire in allergic rhinitis in Thai population.
PG  - e6
LID - 10.5415/apallergy.2019.9.e6 [doi]
LID - e6
AB  - BACKGROUND: Clinical measurement of the severity of allergic rhinitis (AR) can be 
      assessed by symptoms score and patient quality of life (QoL). The magnitude of 
      change in both symptoms and patient QoL should be considered in the management of 
      AR. OBJECTIVE: The aim of this study was to determine the minimal clinically 
      important difference (MCID) in AR in Thai population. METHODS: This prospective 
      study recruited AR patients that attended our clinic during September 2011 to 
      February 2012. The Rhinoconjunctivitis Quality of Life (Rcq-36) questionnaire was 
      used to evaluate patient QoL. The Global Rating of Change Scale (GRCS) was used 
      to assess improvement or deterioration in condition. The MCID was determined 
      using an anchor-based method based on the GRCS, which was compared to the MCID 
      determined by a distribution-based method based on the standard deviation (SD). 
      RESULTS: Three hundred seventy-two patients with chronic rhinitis were recruited. 
      Eighty-four of those had positive skin prick test and be diagnosed as AR. Of 
      those, 79 completed the study and were included in the final analysis. A change 
      of 2 points on the GRCS yielded an MCID for overall QoL of 0.21 +/- 0.57. When 
      applying the distribution-based method, an SD of 1.5 SD yielded an MCID for QoL 
      of 0.27. For the rhinitis symptoms domain, the MCID was 0.42 +/- 0.72. CONCLUSIONS: 
      The MCID for overall QoL and rhinitis symptoms in Thai AR patients was found to 
      be 0.21 +/- 0.57 and 0.42 +/- 0.72, respectively. MCID can be applied for determining 
      the clinical significance of treatment efficacy in AR.
FAU - Tantilipikorn, Pongsakorn
AU  - Tantilipikorn P
AUID- ORCID: 0000-0003-1995-4798
AD  - Division of Rhinology & Allergy, Department of Otorhinolaryngology, Faculty of 
      Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
FAU - Saisombat, Pennapha
AU  - Saisombat P
AD  - Division of Rhinology & Allergy, Department of Otorhinolaryngology, Faculty of 
      Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
FAU - Phonpornpaiboon, Pacharaporn
AU  - Phonpornpaiboon P
AD  - Division of Rhinology & Allergy, Department of Otorhinolaryngology, Faculty of 
      Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
FAU - Pinkaew, Bangon
AU  - Pinkaew B
AD  - Division of Rhinology & Allergy, Department of Otorhinolaryngology, Faculty of 
      Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
FAU - Lermankul, Watcharee
AU  - Lermankul W
AD  - Division of Rhinology & Allergy, Department of Otorhinolaryngology, Faculty of 
      Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
FAU - Bunnag, Chaweewan
AU  - Bunnag C
AD  - Division of Rhinology & Allergy, Department of Otorhinolaryngology, Faculty of 
      Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20190122
PL  - Netherlands
TA  - Asia Pac Allergy
JT  - Asia Pacific allergy
JID - 101561954
PMC - PMC6365662
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - Minimal clinically important difference
OT  - Quality of life
OT  - Rhinoconjunctivitis Quality of Life (Rcq-36) questionnaire
OT  - Thai population
COIS- Conflict of Interest: The authors have no financial conflicts of interest.
EDAT- 2019/02/12 06:00
MHDA- 2019/02/12 06:01
PMCR- 2019/01/01
CRDT- 2019/02/12 06:00
PHST- 2018/09/05 00:00 [received]
PHST- 2019/01/19 00:00 [accepted]
PHST- 2019/02/12 06:00 [entrez]
PHST- 2019/02/12 06:00 [pubmed]
PHST- 2019/02/12 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 2019090104 [pii]
AID - 10.5415/apallergy.2019.9.e6 [doi]
PST - epublish
SO  - Asia Pac Allergy. 2019 Jan 22;9(1):e6. doi: 10.5415/apallergy.2019.9.e6. 
      eCollection 2019 Jan.