PMID- 30744065
OWN - NLM
STAT- MEDLINE
DCOM- 20190613
LR  - 20200309
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 11
IP  - 2
DP  - 2019 Feb 8
TI  - Fcgamma Receptor Type I (CD64)-Mediated Impairment of the Capacity of Dendritic Cells 
      to Activate Specific CD8 T Cells by IgG-opsonized Friend Virus.
LID - 10.3390/v11020145 [doi]
LID - 145
AB  - Dendritic cells (DCs) express Fcgamma receptors (FcgammaRs) for the binding immune 
      complexes (ICs) consisting of IgG and antigens (Ags). IC(-)FcgammaR interactions have 
      been demonstrated to enhance activation and antigen-presenting functions of DCs. 
      Utilizing Friend virus (FV), an oncogenic mouse retrovirus, we investigated the 
      effect of IgG-opsonization of retroviral particles on the infection of DCs and 
      the subsequent presentation of viral antigens by DCs to virus-specific CD8 T 
      cells. We found that opsonization by virus-specific non-neutralizing IgG 
      abrogated DC infection and as a consequence significantly reduced the capacity of 
      DCs to activate virus-specific CD8 T cells. Effects of IgG-opsonization were 
      mediated by the high-affinity FcgammaR type I, CD64, expressed on DCs. Our results 
      suggest that different opsonization patterns on the retroviral surface modulate 
      infection and antigen-presenting functions of DCs, whereby, in contrast to 
      complement, IgG reduces the capacity of DCs to activate cytotoxic T cell (CTL) 
      responses.
FAU - Banki, Zoltan
AU  - Banki Z
AUID- ORCID: 0000-0002-3826-5800
AD  - Division of Virology, Medical University of Innsbruck, Innsbruck, 6020, Austria. 
      zoltan.banki@i-med.ac.at.
FAU - Werner, Roland
AU  - Werner R
AD  - Division of Virology, Medical University of Innsbruck, Innsbruck, 6020, Austria. 
      rol.w@gmx.net.
FAU - Riepler, Lydia
AU  - Riepler L
AD  - Division of Virology, Medical University of Innsbruck, Innsbruck, 6020, Austria. 
      Lydia.Riepler@student.uibk.ac.at.
FAU - Rossler, Annika
AU  - Rossler A
AD  - Division of Virology, Medical University of Innsbruck, Innsbruck, 6020, Austria. 
      Annika.Roessler@i-med.ac.at.
FAU - Mullauer, Brigitte
AU  - Mullauer B
AD  - Division of Virology, Medical University of Innsbruck, Innsbruck, 6020, Austria. 
      brigitte.muellauer@i-med.ac.at.
FAU - Hegen, Verena
AU  - Hegen V
AD  - Division of Virology, Medical University of Innsbruck, Innsbruck, 6020, Austria. 
      verena.hegen@icloud.com.
FAU - Bayer, Wibke
AU  - Bayer W
AD  - Institute for Virology, University Hospital Essen, University of Duisburg-Essen, 
      Essen, Germany. wibke.bayer@uni-due.de.
FAU - Verbeek, J Sjef
AU  - Verbeek JS
AD  - Department of Human Genetics, Leiden University Medical Center, Leiden, the 
      Netherlands. J.S.Verbeek@lumc.nl.
FAU - Dittmer, Ulf
AU  - Dittmer U
AD  - Institute for Virology, University Hospital Essen, University of Duisburg-Essen, 
      Essen, Germany. ulf.dittmer@uni-due.de.
FAU - Stoiber, Heribert
AU  - Stoiber H
AD  - Division of Virology, Medical University of Innsbruck, Innsbruck, 6020, Austria. 
      heribert.stoiber@i-med.ac.at.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190208
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (Fcgr1 protein, mouse)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Antigen-Antibody Complex/immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Dendritic Cells/*immunology/virology
MH  - Friend murine leukemia virus/*immunology
MH  - Immunoglobulin G/immunology
MH  - *Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Receptors, IgG/genetics/*immunology
PMC - PMC6410291
OTO - NOTNLM
OT  - CD8 T cells
OT  - Fcgamma receptors
OT  - IgG-opsonization
OT  - dendritic cells
OT  - friend virus
COIS- The authors declare no conflict of interest.
EDAT- 2019/02/13 06:00
MHDA- 2019/06/14 06:00
PMCR- 2019/02/01
CRDT- 2019/02/13 06:00
PHST- 2018/11/16 00:00 [received]
PHST- 2019/01/31 00:00 [revised]
PHST- 2019/02/01 00:00 [accepted]
PHST- 2019/02/13 06:00 [entrez]
PHST- 2019/02/13 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/02/01 00:00 [pmc-release]
AID - v11020145 [pii]
AID - viruses-11-00145 [pii]
AID - 10.3390/v11020145 [doi]
PST - epublish
SO  - Viruses. 2019 Feb 8;11(2):145. doi: 10.3390/v11020145.