PMID- 30745650
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220401
IS  - 0019-5545 (Print)
IS  - 1998-3794 (Electronic)
IS  - 0019-5545 (Linking)
VI  - 61
IP  - 1
DP  - 2019 Jan-Feb
TI  - Identification of factors affecting treatment outcome in bipolar disorder.
PG  - 22-26
LID - 10.4103/psychiatry.IndianJPsychiatry_346_18 [doi]
AB  - BACKGROUND AND AIM: Treatment outcomes in bipolar disorder are highly variable, 
      and several sociodemographic, clinical characteristics, and comorbidities play an 
      important role. Early recognition of these factors will help the physicians to 
      implement individualized treatment and a better clinical outcome. The present 
      study was aimed at identifying the factors affecting treatment outcomes in 
      bipolar disorder. MATERIALS AND METHODS: All patients diagnosed with bipolar 
      disorder as per diagnostic and statistical manual-IV criteria were included in 
      the study. Patients were followed for 6 months from the day of enrollment. 
      Patient demography, age at bipolar disorder was diagnosed, age at treatment was 
      started, social habits, signs and symptoms, comorbidities, symptoms, treatment 
      pattern, and compliance to treatment were recorded in case record form. Based on 
      the changes in young mania rating scale and Hamilton Depression Rating Scale 
      (HAM-D) score from baseline to last follow-up, the patients were classified as 
      remission and non-remission. Multiple logistic regression was used to identify 
      risk factors associated nonremission in bipolar disorder patients and calculation 
      of odds ratio (OR). RESULTS: The mean age of the study population was 37.6 +/- 14.1 
      years. Out of the 121 patients, 68 (56.2%) were female. At the end of the 
      follow-up period, 41 (33.9%) had remission, and 80 (66.1%) had nonremission. 
      Early onset (OR: 9.77; confidence intervals [CI]: 1.77-86.01), treatment delay 
      (OR: 6.48; CI: 1.27-32.92), treatment noncompliance (OR: 4.64; CI: 1.37-15.64), 
      and single living (OR: 4.26; CI: 1.56-11.66) were independently associated with 
      nonremission in bipolar disorder patients. CONCLUSIONS: Early-onset bipolar 
      disorder, delay in treatment, treatment non-compliance, and single living 
      adversely affect remission in bipolar disorder.
FAU - Vedanarayanan, Lavanya
AU  - Vedanarayanan L
AD  - Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, 
      Manipal, Karnataka, India.
FAU - Munoli, Ravindra
AU  - Munoli R
AD  - Department of Psychiatry, Kasturba Medical College, Manipal Academy of Higher 
      Education, Manipal, Karnataka, India.
FAU - Thunga, Girish
AU  - Thunga G
AD  - Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, 
      Manipal, Karnataka, India.
FAU - Nair, Sreedharan
AU  - Nair S
AD  - Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, 
      Manipal, Karnataka, India.
FAU - Poojari, Pooja
AU  - Poojari P
AD  - Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, 
      Manipal, Karnataka, India.
FAU - Kunhikatta, Vijayanarayana
AU  - Kunhikatta V
AD  - Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, 
      Manipal, Karnataka, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Psychiatry
JT  - Indian journal of psychiatry
JID - 0013255
PMC - PMC6341925
OTO - NOTNLM
OT  - Bipolar disorder
OT  - Hamilton Depression Rating Scale
OT  - early onset
OT  - remission
OT  - young mania rating scale
COIS- There are no conflicts of interest.
EDAT- 2019/02/13 06:00
MHDA- 2019/02/13 06:01
PMCR- 2019/01/01
CRDT- 2019/02/13 06:00
PHST- 2019/02/13 06:00 [entrez]
PHST- 2019/02/13 06:00 [pubmed]
PHST- 2019/02/13 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - IJPsy-61-22 [pii]
AID - 10.4103/psychiatry.IndianJPsychiatry_346_18 [doi]
PST - ppublish
SO  - Indian J Psychiatry. 2019 Jan-Feb;61(1):22-26. doi: 
      10.4103/psychiatry.IndianJPsychiatry_346_18.