PMID- 30746047
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1984-0659 (Print)
IS  - 1984-0063 (Electronic)
IS  - 1984-0063 (Linking)
VI  - 11
IP  - 4
DP  - 2018 Jul-Aug
TI  - A nonparametric methodological analysis of rest-activity rhythm in type 2 
      diabetes.
PG  - 281-289
LID - 10.5935/1984-0063.20180044 [doi]
AB  - The purpose of this study was to analyze the rest-activity rhythm of type 2 
      diabetics mellitus (T2DM) and compare it to healthy controls using the 
      nonparametric analytic approach. Twenty-one diabetics and 21 healthy subjects 
      matched for gender and age were recruited to participate in the study. Data were 
      analyzed using the Independent t-test, Mann-Whitney U test, and Spearmans 
      correlation. T2DM subjects demonstrate lower interdaily stability (IS) (p=.03), 
      higher intradaily variability (p=.046) and lower rhythm amplitude (p=.02) when 
      compared to healthy controls. Also, there was a positive correlation between IS 
      and most active 10 hr (M10) in the average of 24 hours pattern (r =.44; p=.046) 
      in the diabetes group and a negative correlation between IV and M10 in the 
      healthy group (r =-.57; p=.007). These data together suggest that T2DM exhibits a 
      dysfunction in the rest-activity rhythm due to alterations in the circadian 
      function as well as in the homeostatic capacity to maintain sleep; mainly 
      characterized by less consistency across days of the daily circadian signal, 
      higher rhythm fragmentation and lower rhythm amplitude. Future approaches may be 
      developed considering the influence of circadian glucose variations throughout 
      the day on the coupling of the rest-activity rhythm to zeitgeber and rhythm 
      fragmentation.
FAU - Cavalcanti-Ferreira, Paula
AU  - Cavalcanti-Ferreira P
AD  - Loma Linda University, Physical Therapy - Loma Linda - CA - United States.
AD  - California State University, Northridge - CA - United States.
FAU - Berk, Lee
AU  - Berk L
AD  - Loma Linda University, Physical Therapy - Loma Linda - CA - United States.
FAU - Daher, Noha
AU  - Daher N
AD  - Loma Linda University, Physical Therapy - Loma Linda - CA - United States.
FAU - Campus, Tania
AU  - Campus T
AD  - Universidade Federal do Rio Grande do Norte, Physical Therapy - Natal - RN - 
      Brazil.
FAU - Araujo, John
AU  - Araujo J
AD  - Universidade Federal do Rio Grande do Norte, Physical Therapy - Natal - RN - 
      Brazil.
FAU - Petrofsky, Jerrold
AU  - Petrofsky J
AD  - Loma Linda University, Physical Therapy - Loma Linda - CA - United States.
FAU - Lohman, Everett
AU  - Lohman E
AD  - Loma Linda University, Physical Therapy - Loma Linda - CA - United States.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Sleep Sci
JT  - Sleep science (Sao Paulo, Brazil)
JID - 101598477
PMC - PMC6361299
OTO - NOTNLM
OT  - Circadian Rhythm
OT  - Diabetes Mellitus, Type 2
OT  - Sleep Wake Disorders
EDAT- 2019/02/13 06:00
MHDA- 2019/02/13 06:01
PMCR- 2018/07/01
CRDT- 2019/02/13 06:00
PHST- 2019/02/13 06:00 [entrez]
PHST- 2019/02/13 06:00 [pubmed]
PHST- 2019/02/13 06:01 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - 10.5935/1984-0063.20180044 [doi]
PST - ppublish
SO  - Sleep Sci. 2018 Jul-Aug;11(4):281-289. doi: 10.5935/1984-0063.20180044.