PMID- 30746344
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2287-3732 (Print)
IS  - 2287-3740 (Electronic)
IS  - 2287-3732 (Linking)
VI  - 8
IP  - 1
DP  - 2019 Jan
TI  - Effect of Eicosapentaenoic Acid Supplementation on Paraoxonase 2 Gene Expression 
      in Patients with Type 2 Diabetes Mellitus: a Randomized Double-blind Clinical 
      Trial.
PG  - 17-27
LID - 10.7762/cnr.2019.8.1.17 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is recognized as one of the most prevalent 
      metabolic diseases, and it is mostly associated with oxidative stress, 
      atherosclerosis and dyslipidemia. Paraoxonase 2 (PON2) due to its antioxidant 
      properties may play a role in the atherosclerosis development. Although 
      long-chain omega-3 polyunsaturated fatty acids, such as eicosapentaenoic acid 
      (EPA) have been shown to reduce the risk of cardiovascular disease, the exact 
      mechanism of action is still unknown. Our goal in this study was to determine the 
      effect of EPA administration on gene expression of PON2 in patients with T2DM. 
      Present study was a randomized, controlled double-blind trial. Thirty-six 
      patients with T2DM were randomly allocated to receive 2 g/day EPA (n = 18) or 
      placebo (n = 18) for 8 weeks. There were no significant differences between 2 
      groups concerning demographic or biochemical variables, and dietary intakes as 
      well (p > 0.05). However, patients received EPA showed a significant increase in 
      the gene expression of PON2 compared with placebo group (p = 0.027). In addition, 
      high-density lipoprotein cholesterol increased and fasting blood sugar decreased 
      significantly after EPA supplementation compared with control group. Taken 
      together, supplementation with 2 g/day EPA could be atheroprotective via the 
      upregulation of PON2 in patients with T2DM. TRIAL REGISTRATION: 
      ClinicalTrials.gov Identifier: NCT03258840.
FAU - Golzari, Mohammad Hassan
AU  - Golzari MH
AUID- ORCID: 0000-0001-5810-7044
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran 14155-6446, Iran.
FAU - Javanbakht, Mohammad Hassan
AU  - Javanbakht MH
AUID- ORCID: 0000-0001-7646-6657
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran 14155-6446, Iran.
FAU - Ghaedi, Ehsan
AU  - Ghaedi E
AUID- ORCID: 0000-0003-4095-1591
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran 14155-6446, Iran.
FAU - Mohammadi, Hamed
AU  - Mohammadi H
AUID- ORCID: 0000-0003-2046-7356
AD  - Student Research Committee, Department of Clinical Nutrition, School of Nutrition 
      and Food Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, 
      Iran.
FAU - Djalali, Mahmoud
AU  - Djalali M
AUID- ORCID: 0000-0002-7357-3964
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran 14155-6446, Iran.
LA  - eng
SI  - ClinicalTrials.gov/NCT03258840
PT  - Journal Article
DEP - 20190128
PL  - Korea (South)
TA  - Clin Nutr Res
JT  - Clinical nutrition research
JID - 101592483
PMC - PMC6355950
OTO - NOTNLM
OT  - Eicosapentaenoic acid
OT  - Gene expression
OT  - Paraoxonase-2
OT  - Randomized Controlled Trial
OT  - Type 2 diabetes mellitus
COIS- Conflict of Interest: The authors declare that they have no competing interests.
EDAT- 2019/02/13 06:00
MHDA- 2019/02/13 06:01
PMCR- 2019/01/01
CRDT- 2019/02/13 06:00
PHST- 2018/08/16 00:00 [received]
PHST- 2018/11/15 00:00 [revised]
PHST- 2018/11/20 00:00 [accepted]
PHST- 2019/02/13 06:00 [entrez]
PHST- 2019/02/13 06:00 [pubmed]
PHST- 2019/02/13 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.7762/cnr.2019.8.1.17 [doi]
PST - epublish
SO  - Clin Nutr Res. 2019 Jan 28;8(1):17-27. doi: 10.7762/cnr.2019.8.1.17. eCollection 
      2019 Jan.