PMID- 30747271
OWN - NLM
STAT- MEDLINE
DCOM- 20210106
LR  - 20220410
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Linking)
VI  - 59
IP  - 2
DP  - 2020 Mar
TI  - Reduced meal frequency alleviates high-fat diet-induced lipid accumulation and 
      inflammation in adipose tissue of pigs under the circumstance of fixed feed 
      allowance.
PG  - 595-608
LID - 10.1007/s00394-019-01928-3 [doi]
AB  - PURPOSE: The present study was conducted to determine whether reduced meal 
      frequency (MF) could restore high-fat diet (HFD)-modified phenotypes and 
      microbiota under the condition of fixed feed allowance. METHODS: A total of 32 
      barrows with initial weight of 61.6 +/- 0.8 kg were assigned to two diets [control 
      diet (CON) versus HFD] and two meal frequencies [12 equal meals/day (M12) versus 
      2 equal meals/day (M2)], the trial lasted 8 weeks. The lipid metabolism and 
      inflammatory response in adipose tissue as well as the profiles of intestinal 
      microbiota and bacterial-derived metabolites were determined. RESULTS: M2 versus 
      M12 feeding regimen decreased perirenal fat weight and serum triglyceride and 
      liposaccharide (LPS) concentrations in HFD-fed pigs (P < 0.05). Reduced MF 
      down-regulated mRNA expression of lipoprotein lipase, CD36 molecule, interleukin 
      1 beta, tumor necrosis factor alpha, toll-like receptor 4, myeloid 
      differentiation factor 88 (MYD88), and nuclear factor kappa beta 1 as well as 
      protein expression of MYD88 in perirenal fat of HFD-fed pigs (P < 0.05). M2 
      feeding regimen increased abundance of Prevotella and decreased abundance of 
      Bacteroides in colonic content of HFD-fed pigs (P < 0.05). No difference in 
      short-chain fatty acids (SCFAs) profile in colonic content was observed among 
      four groups (P > 0.05). CONCLUSION: Our results suggested that M2 versus M12 
      feeding regimen ameliorated HFD-induced fat deposition and inflammatory response 
      by decreasing fatty acid uptake and deactivating LPS/TLR4 signaling pathway in 
      adipose tissue and restoring microbiota composition in distal intestine, without 
      affecting SCFAs profile in distal luminal content.
FAU - Yan, Honglin
AU  - Yan H
AD  - School of Life Science and Engineering, Southwest University of Science and 
      Technology, 621010, Mianyang, People's Republic of China.
FAU - Cao, Shanchuan
AU  - Cao S
AD  - School of Life Science and Engineering, Southwest University of Science and 
      Technology, 621010, Mianyang, People's Republic of China.
FAU - Li, Yan
AU  - Li Y
AD  - School of Life Science and Engineering, Southwest University of Science and 
      Technology, 621010, Mianyang, People's Republic of China.
FAU - Zhang, Hongfu
AU  - Zhang H
AD  - State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese 
      Academy of Agricultural Sciences, 100193, Beijing, People's Republic of China.
FAU - Liu, Jingbo
AU  - Liu J
AD  - School of Life Science and Engineering, Southwest University of Science and 
      Technology, 621010, Mianyang, People's Republic of China. liuswust@163.com.
AD  - State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese 
      Academy of Agricultural Sciences, 100193, Beijing, People's Republic of China. 
      liuswust@163.com.
LA  - eng
GR  - 31802069/National Natural Science Foundation of China/
GR  - 2018JY0225/Sichuan Science and Technology Program/
PT  - Journal Article
DEP - 20190212
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Lipids)
SB  - IM
MH  - Adipose Tissue/*physiopathology
MH  - Animals
MH  - Diet, High-Fat/*adverse effects
MH  - Disease Models, Animal
MH  - Feeding Behavior/*physiology
MH  - Inflammation/*physiopathology
MH  - Lipid Metabolism/*physiology
MH  - Lipids/blood
MH  - Swine
OTO - NOTNLM
OT  - High-fat diet
OT  - Inflammation
OT  - Lipid metabolism
OT  - Meal frequency
OT  - Microbiota
OT  - Short-chain fatty acids
EDAT- 2019/02/13 06:00
MHDA- 2021/01/07 06:00
CRDT- 2019/02/13 06:00
PHST- 2018/11/20 00:00 [received]
PHST- 2019/02/06 00:00 [accepted]
PHST- 2019/02/13 06:00 [pubmed]
PHST- 2021/01/07 06:00 [medline]
PHST- 2019/02/13 06:00 [entrez]
AID - 10.1007/s00394-019-01928-3 [pii]
AID - 10.1007/s00394-019-01928-3 [doi]
PST - ppublish
SO  - Eur J Nutr. 2020 Mar;59(2):595-608. doi: 10.1007/s00394-019-01928-3. Epub 2019 
      Feb 12.