PMID- 30753155
OWN - NLM
STAT- MEDLINE
DCOM- 20200804
LR  - 20211204
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 57
IP  - 9
DP  - 2019 Aug 27
TI  - Narrowed reference intervals for complete blood count in a multiethnic 
      population.
PG  - 1382-1387
LID - 10.1515/cclm-2018-1263 [doi]
AB  - Background Biological variation studies have shown that the complete blood count 
      (CBC) has narrow within-individual variation and wide group variation, indicating 
      that the use of reference intervals (RIs) is challenging. The aim of this study 
      was to examine differences in CBC RIs according to race/ethnicity in a 
      multiethnic population at a hospital in San Francisco in hopes of improving the 
      medical utility of CBC testing. Methods Subject data were obtained by screening 
      CBC results from the medical records of outpatients meeting certain criteria who 
      visited Zuckerberg San Francisco General Hospital from April 2017 to January 
      2018. From these records, sex- and race/ethnicity-specific CBC RIs were 
      calculated as the 2.5th to 97.5th percentiles. Results From a total of 552 
      subjects, 47.9% were male (65 White, 50 Black, 71 Hispanic and 54 Asian) and 
      52.1% were female (51 White, 39 Black, 122 Hispanic and 72 Asian). The RIs of 
      neutrophil, lymphocyte and eosinophil counts; and hemoglobin, mean corpuscular 
      volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin 
      concentration (MCHC) showed significant differences (p<0.05) among the four 
      racial/ethnic groups: neutrophil, lymphocyte and eosinophil counts; and MCHC in 
      males, and hemoglobin, MCV, MCH and MCHC in females. Conclusions 
      Race/ethnicity-specific CBC RIs should be taken into consideration in a 
      multiethnic population to better interpret patient status and make progress 
      toward precision medicine.
FAU - Lee, Seungok
AU  - Lee S
AD  - Department of Laboratory Medicine, Incheon St. Mary's Hospital, The Catholic 
      University of Korea, Incheon, Republic of Korea.
AD  - Department of Laboratory Medicine, College of Medicine, The Catholic University 
      of Korea, Seoul, Republic of Korea.
FAU - Ong, Chui Mei
AU  - Ong CM
AD  - Department of Laboratory Medicine, University of California, San Francisco, CA, 
      USA.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Department of Laboratory Medicine, University of California, San Francisco, CA, 
      USA.
FAU - Wu, Alan H B
AU  - Wu AHB
AD  - Department of Laboratory Medicine, University of California, San Francisco, CA 
      94110, USA.
AD  - Clinical Laboratories, Room 2M27, San Francisco General Hospital, 1001 Potrero 
      Ave., San Francisco, CA 94110, USA, Phone: +1-415-206-3540, Fax: +1-415-206-3045.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Cell Count/*standards/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Racial Groups/*classification
MH  - Reference Values
MH  - Retrospective Studies
OTO - NOTNLM
OT  - complete blood count
OT  - multiethnic population
OT  - race/ethnicity
OT  - reference interval
EDAT- 2019/02/13 06:00
MHDA- 2020/08/05 06:00
CRDT- 2019/02/13 06:00
PHST- 2018/11/26 00:00 [received]
PHST- 2019/01/15 00:00 [accepted]
PHST- 2019/02/13 06:00 [pubmed]
PHST- 2020/08/05 06:00 [medline]
PHST- 2019/02/13 06:00 [entrez]
AID - cclm-2018-1263 [pii]
AID - 10.1515/cclm-2018-1263 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2019 Aug 27;57(9):1382-1387. doi: 10.1515/cclm-2018-1263.