PMID- 30753222
OWN - NLM
STAT- MEDLINE
DCOM- 20191111
LR  - 20200309
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 2
DP  - 2019
TI  - Histogram analysis of prostate cancer on dynamic contrast-enhanced magnetic 
      resonance imaging: A preliminary study emphasizing on zonal difference.
PG  - e0212092
LID - 10.1371/journal.pone.0212092 [doi]
LID - e0212092
AB  - BACKGROUND: This study evaluated the performance of histogram analysis in the 
      time course of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for 
      differentiating cancerous tissues from benign tissues in the prostate. METHODS: 
      We retrospectively analyzed the histograms of DCE-MRI of 30 patients. Histograms 
      within regions of interest(ROI) in the peripheral zone (PZ) and transitional zone 
      (TZ) were separately analyzed. The maximum difference wash-in slope (MWS) and 
      delay phase slope (DPS) were defined for each voxel. Differences in histogram 
      parameters, namely the mean, standard deviation (SD), the coefficient of 
      variation (CV), kurtosis, skewness, interquartile range (IQR), percentile (P10, 
      P25, P75, P90, and P90P10), Range, and modified full width at half-maximum 
      (mFWHM) between cancerous and benign tissues were assessed. RESULTS: In the TZ, 
      CV for ROIs of 7.5 and 10mm was the only significantly different parameter of the 
      MWS (P = 0.034 and P = 0.004, respectively), whereas many parameters of the DPS 
      (mean, skewness, P10, P25, P50, P75 and P90) differed significantly (P = 
      <0.001-0.016 and area under the curve [AUC] = 0.73-0.822). In the PZ, all 
      parameters of the MWS exhibited significant differences, except kurtosis and 
      skewness in the ROI of 7.5mm(P = <0.001-0.017 and AUC = 0.865-0.898). SD, IQR, 
      mFWHM, P90P10 and Range were also significant differences in the DPS (P = 
      0.001-0.035). CONCLUSION: The histogram analysis of DCE-MRI is a potentially 
      useful approach for differentiating prostate cancer from normal tissues. 
      Different histogram parameters of the MWS and DPS should be applied in the TZ and 
      PZ.
FAU - Lai, Chih-Ching
AU  - Lai CC
AD  - Department of Biomedical Engineering and Environmental Sciences, National Tsing 
      Hua University, Hsinchu, Taiwan.
FAU - Huang, Pin-Hsun
AU  - Huang PH
AD  - Department of Biomedical Engineering and Environmental Sciences, National Tsing 
      Hua University, Hsinchu, Taiwan.
FAU - Wang, Fu-Nien
AU  - Wang FN
AD  - Department of Biomedical Engineering and Environmental Sciences, National Tsing 
      Hua University, Hsinchu, Taiwan.
FAU - Shen, Shu-Huei
AU  - Shen SH
AUID- ORCID: 0000-0002-2776-4671
AD  - Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.
AD  - School of Medicine, Taipei, National Yang-Ming University, Taipei, Taiwan.
FAU - Wang, Hsin-Kai
AU  - Wang HK
AD  - Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.
AD  - School of Medicine, Taipei, National Yang-Ming University, Taipei, Taiwan.
FAU - Liu, Hsian-Tzu
AU  - Liu HT
AD  - Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.
AD  - School of Medicine, Taipei, National Yang-Ming University, Taipei, Taiwan.
FAU - Chung, Hsiao-Jen
AU  - Chung HJ
AD  - School of Medicine, Taipei, National Yang-Ming University, Taipei, Taiwan.
AD  - Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Lin, Tzu-Ping
AU  - Lin TP
AD  - School of Medicine, Taipei, National Yang-Ming University, Taipei, Taiwan.
AD  - Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Chang, Yen-Hwa
AU  - Chang YH
AD  - School of Medicine, Taipei, National Yang-Ming University, Taipei, Taiwan.
AD  - Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Pan, Chin-Chen
AU  - Pan CC
AD  - School of Medicine, Taipei, National Yang-Ming University, Taipei, Taiwan.
AD  - Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Peng, Shin-Lei
AU  - Peng SL
AD  - Department of Biomedical Imaging and Radiological Science, China Medical 
      University, Taichung, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190212
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Contrast Media)
SB  - IM
MH  - Aged
MH  - *Contrast Media
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Prostatic Neoplasms/*diagnostic imaging/pathology
MH  - ROC Curve
MH  - Retrospective Studies
PMC - PMC6372178
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/02/13 06:00
MHDA- 2019/11/12 06:00
PMCR- 2019/02/12
CRDT- 2019/02/13 06:00
PHST- 2017/10/04 00:00 [received]
PHST- 2019/01/28 00:00 [accepted]
PHST- 2019/02/13 06:00 [entrez]
PHST- 2019/02/13 06:00 [pubmed]
PHST- 2019/11/12 06:00 [medline]
PHST- 2019/02/12 00:00 [pmc-release]
AID - PONE-D-17-35851 [pii]
AID - 10.1371/journal.pone.0212092 [doi]
PST - epublish
SO  - PLoS One. 2019 Feb 12;14(2):e0212092. doi: 10.1371/journal.pone.0212092. 
      eCollection 2019.