PMID- 30753838
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20191230
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 448
DP  - 2019 Apr 28
TI  - ZBTB7A, a miR-663a target gene, protects osteosarcoma from endoplasmic reticulum 
      stress-induced apoptosis by suppressing LncRNA GAS5 expression.
PG  - 105-116
LID - S0304-3835(19)30076-X [pii]
LID - 10.1016/j.canlet.2019.01.046 [doi]
AB  - Many studies have uncovered the essential role of ZBTB7A in regulating 
      tumourigenesis. However, its functional significance in cell responses to 
      endoplasmic reticulum stress (ER stress) remains poorly understood. Here we 
      report that ZBTB7A functions as an important prosurvival factor in osteosarcoma 
      cells undergoing pharmacological ER stress-induced by tunicamycin (TM) or 
      thapsigargin (TG). The downregulation of ZBTB7A expression by ER stress promoted 
      cell apoptosis in vitro and in vivo. ZBTB7A expression levels were increased in 
      osteosarcoma tissues and elevated ZBTB7A was associated with osteosarcoma 
      metastasis. Further mechanistic studies revealed that miR-663a induced by ER 
      stress directly bound to the 3'UTR of ZBTB7A and contributed to ER stress-induced 
      ZBTB7A downregulation in osteosarcoma cells. Additionally, our data revealed that 
      ZBTB7A bound to the promoter of LncRNA GAS5 and transcriptionally suppressed 
      LncRNA GAS5 expression, leading to a decline in ER stress-induced cell apoptosis. 
      Collectively, our findings reveal the prosurvival role of ZBTB7A in osteosarcoma 
      adaptation to ER stress and suggest that the miR-663a-ZBTB7A-LncRNAGAS5 pathway 
      is essential for the survival of human osteosarcoma cells under ER stress.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Zhang, Lu
AU  - Zhang L
AD  - The Second Affiliated Hospital & Institute of Cancer Stem Cell, Dalian Medical 
      University, Dalian, Liaoning, 116044, PR China.
FAU - Wang, Yuan
AU  - Wang Y
AD  - The Second Affiliated Hospital & Institute of Cancer Stem Cell, Dalian Medical 
      University, Dalian, Liaoning, 116044, PR China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Laboratory of Pathogenic Biology, College of Basic Medical Science, Dalian 
      Medical University, Dalian, 116044, China.
FAU - Xia, Xin
AU  - Xia X
AD  - The Second Affiliated Hospital & Institute of Cancer Stem Cell, Dalian Medical 
      University, Dalian, Liaoning, 116044, PR China.
FAU - Chao, Yulin
AU  - Chao Y
AD  - The Second Affiliated Hospital & Institute of Cancer Stem Cell, Dalian Medical 
      University, Dalian, Liaoning, 116044, PR China.
FAU - He, Ruiping
AU  - He R
AD  - The Second Affiliated Hospital & Institute of Cancer Stem Cell, Dalian Medical 
      University, Dalian, Liaoning, 116044, PR China.
FAU - Han, Chuanchun
AU  - Han C
AD  - The Second Affiliated Hospital & Institute of Cancer Stem Cell, Dalian Medical 
      University, Dalian, Liaoning, 116044, PR China. Electronic address: 
      hanchuanchun@163.com.
FAU - Zhao, Wenzhi
AU  - Zhao W
AD  - The Second Affiliated Hospital & Institute of Cancer Stem Cell, Dalian Medical 
      University, Dalian, Liaoning, 116044, PR China. Electronic address: 
      drzwz@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190210
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MIRN663 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Transcription Factors)
RN  - 0 (ZBTB7A protein, human)
SB  - IM
MH  - Apoptosis/*physiology
MH  - Cell Line, Tumor
MH  - DNA-Binding Proteins/*physiology
MH  - Endoplasmic Reticulum Stress/*physiology
MH  - Humans
MH  - MicroRNAs/*physiology
MH  - Osteosarcoma/genetics/*metabolism
MH  - RNA, Long Noncoding/*metabolism
MH  - Transcription Factors/*physiology
OTO - NOTNLM
OT  - ER stress
OT  - GAS5
OT  - Osteosarcoma
OT  - ZBTB7A
OT  - miR-663a
EDAT- 2019/02/13 06:00
MHDA- 2019/12/31 06:00
CRDT- 2019/02/13 06:00
PHST- 2018/10/14 00:00 [received]
PHST- 2019/01/26 00:00 [revised]
PHST- 2019/01/29 00:00 [accepted]
PHST- 2019/02/13 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
PHST- 2019/02/13 06:00 [entrez]
AID - S0304-3835(19)30076-X [pii]
AID - 10.1016/j.canlet.2019.01.046 [doi]
PST - ppublish
SO  - Cancer Lett. 2019 Apr 28;448:105-116. doi: 10.1016/j.canlet.2019.01.046. Epub 
      2019 Feb 10.