PMID- 30753933
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 26
IP  - 8
DP  - 2020 Aug
TI  - Resting Oxygen Consumption and Heart Failure: Importance of Measurement for 
      Determination of Cardiac Output With the Use of the Fick Principle.
PG  - 664-672
LID - S1071-9164(18)30264-1 [pii]
LID - 10.1016/j.cardfail.2019.02.004 [doi]
AB  - BACKGROUND: Resting oxygen consumption (VO(2)) is often estimated and frequently 
      used to guide therapeutic decisions in symptomatic heart failure (HF) patients. 
      The relationship between resting VO(2) and symptomatic HF and the accuracy of 
      estimations of VO(2) in this population are unknown. METHODS AND RESULTS: We 
      performed a cross-sectional study of HF patients (n = 691) and healthy control 
      subjects (n = 77). VO(2) was measured with the use of a metabolic cart, and 
      estimated VO(2) was calculated with the use of the Dehmer, LaFarge, and Bergstra 
      formulas and the thermodilution method. The measured and estimated VO(2) were 
      compared and the potential impact of estimations determined. In the multivariable 
      model, resting VO(2) decreased with increasing New York Heart Association (NYHA) 
      functional class in a stepwise fashion (beta NYHA functional class IV vs 
      control = -36 mL O(2)/min; P < .001). Estimations of VO(2) with the use of 
      derived equations diverged from measured values, particularly for patients with 
      NYHA functional class IV limitations. The percentage difference of measured VO(2) 
      versus estimated VO(2) was >25% in 39% (n = 271), 25% (n = 170), 82% (n = 566), 
      and 39% (n = 271) of HF patients when using the Dehmer, LaFarge, Bergstra, and 
      thermodilution-derived estimations of VO(2) respectively. CONCLUSIONS: Resting 
      VO(2) decreases with increasing NYHA functional class and is lower than in 
      control subjects. Using estimations of VO(2) to calculate CO may introduce 
      clinically important error.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Grafton, Gillian
AU  - Grafton G
AD  - Division of Cardiovascular Medicine, Henry Ford, Detroit, Michigan.
FAU - Cascino, Thomas M
AU  - Cascino TM
AD  - Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan. 
      Electronic address: tcascino@med.umich.edu.
FAU - Perry, Daniel
AU  - Perry D
AD  - Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan.
FAU - Ashur, Carmel
AU  - Ashur C
AD  - Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan.
FAU - Koelling, Todd M
AU  - Koelling TM
AD  - Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan.
LA  - eng
GR  - T32 HL007853/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20190210
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Cardiac Output
MH  - Cross-Sectional Studies
MH  - *Heart Failure/diagnosis
MH  - Humans
MH  - Oxygen
MH  - Oxygen Consumption
MH  - Thermodilution
PMC - PMC6689258
MID - NIHMS1523629
OTO - NOTNLM
OT  - Heart failure
OT  - diagnostic testing
OT  - hemodynamics
COIS- Conflicts of Interest Dr. Grafton: None. Dr. Cascino: None. Dr. Perry: None. Dr. 
      Ashur: None. Dr. Koelling receives research support from scPharmaceuticals.
EDAT- 2019/02/13 06:00
MHDA- 2021/08/19 06:00
PMCR- 2021/08/01
CRDT- 2019/02/13 06:00
PHST- 2018/07/19 00:00 [received]
PHST- 2019/02/01 00:00 [revised]
PHST- 2019/02/03 00:00 [accepted]
PHST- 2019/02/13 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2019/02/13 06:00 [entrez]
PHST- 2021/08/01 00:00 [pmc-release]
AID - S1071-9164(18)30264-1 [pii]
AID - 10.1016/j.cardfail.2019.02.004 [doi]
PST - ppublish
SO  - J Card Fail. 2020 Aug;26(8):664-672. doi: 10.1016/j.cardfail.2019.02.004. Epub 
      2019 Feb 10.